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    Process for the preparation of N-phosphonomethylglycine and derivatives thereof
    4.
    发明授权
    Process for the preparation of N-phosphonomethylglycine and derivatives thereof 有权
    N-膦酰基甲基甘氨酸及其衍生物的制备方法

    公开(公告)号：US07750180B2

    公开(公告)日：2010-07-06

    申请号：US10924265

    申请日：2004-08-23

    申请人： James P. Coleman ,  Jerry R. Ebner ,  Eric A. Haupfear ,  Patrick J. Lennon ,  Joseph A. Schaper ,  Samuel J. Tremont ,  Serge G. Wolfson ,  Philip H. Brodsky

    发明人： James P. Coleman ,  Jerry R. Ebner ,  Eric A. Haupfear ,  Patrick J. Lennon ,  Joseph A. Schaper ,  Samuel J. Tremont ,  Serge G. Wolfson ,  Philip H. Brodsky

    IPC分类号： C07F9/22

    CPC分类号： C07F9/3813 ,  Y02P20/582

    摘要： N-phosphonomethylamines are produced by reaction of an amine substrate with a halomethylphosphonic acid or salt thereof, a hydroxymethylphosphonic acid or salt thereof, or a dehydrated self-ester dimer, trimer or oligomer of hydroxymethylphosphonic acid. Among the products that may be prepared according to the process are N-phosphonomethylaminocarboxylic acids such as (e.g.) glyphosate, N-phosphonomethylaminoalkanols such as (e.g.) hydroxyethlaminomethylphosphonic acid, and N-acylaminomethylphosphonic acids such as (e.g.) N-carbamylaminomethylphosphonic acid. Certain reactions are conducted with a substantial excess of amine reactant in order to drive the conversion while avoiding excessive formation of bis(N-phosphonomethyl)amine by-products. Other reactions use a secondary amine substrate (such as iminodiacetic acid) and can be conducted at substantial equimolar ratios of halomethylaminomethylphosphonic acid or hydroxyaminomethylphosphonic acid to secondary amine reactant without significant formation of bis(phosphonomethyl)amine by-products. Further disclosed is a process for the preparation of hydroxymethylphosphonic acid self-ester dimers, trimers and oligomers by azeotropic dehydration.

    摘要翻译： N-膦酰基甲胺通过胺底物与卤甲基膦酸或其盐，羟甲基膦酸或其盐或羟甲基膦酸的脱水的自酯二聚物，三聚体或低聚物的反应来制备。 可根据该方法制备的产物是N-膦酰基乙基氨基羧酸，例如（例如）草甘膦，N-膦酰基甲基氨基链烷醇如（例如）羟基乙基氨基甲基膦酸和N-酰基氨基甲基膦酸如（例如）N-氨基甲酰基氨基甲基膦酸。 某些反应用大量过量的胺反应物进行，以驱动转化，同时避免过度形成双（N-膦酰基甲基）胺副产物。 其他反应使用仲胺底物（例如亚氨基二乙酸），并且可以以基本上等摩尔比率的卤代甲基氨基甲基膦酸或羟基氨基甲基膦酸与仲胺反应物进行反应，而不显着形成双（膦酰基甲基）胺副产物。 进一步公开了通过共沸脱水制备羟甲基膦酸自酯二聚体，三聚体和低聚物的方法。

    Reaction systems for making N-(phosphonomethyl) glycine compounds
    5.
    发明授权
    Reaction systems for making N-(phosphonomethyl) glycine compounds 有权
    制备N-（膦酰基甲基）甘氨酸化合物的反应体系

    公开(公告)号：US07504534B2

    公开(公告)日：2009-03-17

    申请号：US11285721

    申请日：2005-11-22

    申请人： Eric A. Haupfear ,  Henry Chien ,  Eduardo Casanova ,  William B. Hooper

    发明人： Eric A. Haupfear ,  Henry Chien ,  Eduardo Casanova ,  William B. Hooper

    IPC分类号： C07F9/22

    CPC分类号： C07F9/3813 ,  Y02P20/582

    摘要： This invention generally relates to liquid phase oxidation processes for making N-(phosphonomethyl)glycine (also known in the agricultural chemical industry as glyphosate) and related compounds. This invention, for example, particularly relates to processes wherein an N-(phosphonomethyl)iminodiacetic acid (NPMIDA) substrate (i.e., N-(phosphonomethyl)iminodiacetic acid, a salt of N-(phosphonomethyl)iminodiacetic acid, or an ester of N-(phosphonomethyl)iminodiacetic acid) is continuously oxidized to form an N-(phosphonomethyl)glycine product (i.e., N-(phosphonomethyl)glycine, a salt of N-(phosphonomethyl)glycine, or an ester of N-(phosphonomethyl)glycine). This invention also, for example, particularly relates to processes wherein an N-(phosphonomethyl)iminodiacetic acid substrate is oxidized to form an N-(phosphonomethyl)glycine product, which, in turn, is crystallized (at least in part) in an adiabatic crystallizer.

    摘要翻译： 本发明一般涉及制备N-（膦酰基甲基）甘氨酸（农业化学工业中也称为草甘膦）和相关化合物的液相氧化方法。 本发明特别涉及N-（膦酰基甲基）亚氨基二乙酸（NPMIDA）底物（即N-（膦酰基甲基）亚氨基二乙酸，N-（膦酰基甲基）亚氨基二乙酸的盐或N - （膦酰基甲基）亚氨基二乙酸）连续氧化形成N-（膦酰基甲基）甘氨酸产物（即N-（膦酰基甲基）甘氨酸，N-（膦酰基甲基）甘氨酸的盐或N-（膦酰基甲基）甘氨酸的酯 ）。 本发明还特别涉及其中N-（膦酰基甲基）亚氨基二乙酸底物被氧化以形成N-（膦酰基甲基）甘氨酸产物的方法，其反过来在绝热中结晶（至少部分地） 结晶器。

    Control of N-(phosphonomethyl)iminodiacetic acid conversion in manufacture of glyphosate
    10.
    发明授权
    Control of N-(phosphonomethyl)iminodiacetic acid conversion in manufacture of glyphosate 有权
    控制草甘膦生产中N-（膦酰基甲基）亚氨基二乙酸转化

    公开(公告)号：US09409935B2

    公开(公告)日：2016-08-09

    申请号：US12884289

    申请日：2010-09-17

    申请人： Eric A. Haupfear

    发明人： Eric A. Haupfear

    IPC分类号： G01N31/00 ,  C07F9/38

    CPC分类号： G01N31/22 ,  C07F9/3813 ,  G01N31/00 ,  Y10T436/163333 ,  Y10T436/204998

    摘要： This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.

    摘要翻译： 本发明涉及从N-（膦酰基甲基）亚氨基二乙酸（“PMIDA”）制备N-（膦酰基甲基）甘氨酸（“草甘膦”），更具体地说，涉及用于控制PMIDA转化的方法，用于鉴定反应 关于PMIDA转化的终点和具有受控PMIDA含量的草甘膦产品的制备。