公开(公告)号：US20210393954A1

公开(公告)日：2021-12-23

申请号：US17466933

申请日：2021-09-03

Applicant: EnteroMed Ltd

Inventor： Victor Eugene PIKOV

IPC: A61N1/36 ,  A61N1/08

Abstract: Systems for delivering therapy to an intestinal muscle in a patient may comprise a cardiac sensor, an intestinal sensor, an implantable pulse generator and a signal delivery device. The signal delivery device may be configured to deliver a stimulation signal to the muscle. The implantable pulse generator may comprise a microcontroller configured to receive cardiac data from the cardiac sensor and calculate a heart rate parameter therefrom, receive intestinal activity data from the intestinal sensor and calculate an intestinal activity parameter therefrom, determine a physiological state of a patient based on the parameters, adjust a stimulation parameter of the stimulation signal based on the determined state, and instruct the signal delivery device to deliver an adjusted stimulation signal.

公开(公告)号：US12017073B2

公开(公告)日：2024-06-25

申请号：US16874522

申请日：2020-05-14

Applicant: EnteroMed Ltd

Inventor： Victor Eugene Pikov ,  Jianfeng Chen ,  Min Ni

IPC: A61N1/36

CPC classification number: A61N1/36139 ,  A61N1/3606

Abstract: Systems for delivering therapy to a nerve in a patient may comprise a plurality of sensors, such as a cardiac sensor, a disease activity sensor, and a bodily activity sensor, an implantable pulse generator, and an implantable signal delivery device. The implantable signal delivery device may be configured to deliver a stimulation signal to the nerve. The implantable pulse generator may comprise a microcontroller configured to calculate a heart rate parameter from cardiac data received from the cardiac sensor, calculate a disease activity parameter from disease activity data received from the disease activity sensor, calculate a bodily activity parameter from bodily activity data received from a bodily activity sensor, determine an autonomic nervous system state, physiological state, and/or disease state of the patient based on the heart rate parameter, the disease activity parameter, and the bodily activity parameter, and adjust a nerve stimulation parameter of a stimulation signal based on the determined autonomic nervous system state, the physiological state, and/or the disease state.

公开(公告)号：US20240299748A1

公开(公告)日：2024-09-12

申请号：US18664239

申请日：2024-05-14

Applicant: EnteroMed Ltd

Inventor： Victor Eugene Pikov ,  Jianfeng Chen ,  Min Ni

IPC: A61N1/36

CPC classification number: A61N1/36139 ,  A61N1/3606

Abstract: Systems for delivering therapy to a nerve in a patient may comprise a plurality of sensors, such as a cardiac sensor, a disease activity sensor, and a bodily activity sensor, an implantable pulse generator, and an implantable signal delivery device. The implantable signal delivery device may be configured to deliver a stimulation signal to the nerve. The implantable pulse generator may comprise a microcontroller configured to calculate a heart rate parameter from cardiac data received from the cardiac sensor, calculate a disease activity parameter from disease activity data received from the disease activity sensor, calculate a bodily activity parameter from bodily activity data received from a bodily activity sensor, determine an autonomic nervous system state, physiological state, and/or disease state of the patient based on the heart rate parameter, the disease activity parameter, and the bodily activity parameter, and adjust a nerve stimulation parameter of a stimulation signal based on the determined autonomic nervous system state, the physiological state, and/or the disease state.