公开(公告)号：US07744890B2

公开(公告)日：2010-06-29

申请号：US11974312

申请日：2007-10-12

申请人： Pilarin Elizabeth Nichols ,  Donna L. Luisi

发明人： Pilarin Elizabeth Nichols ,  Donna L. Luisi

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K1/34

CPC分类号： A61K39/39591

摘要： Methods for reducing the opalescent appearance of a protein preparation by modifying the ionic strength of the preparation, as well as compositions, e.g., pharmaceutical compositions, of concentrated protein with decreased opalescence are disclosed. Purification methods which monitor and/or reduce the salt concentrations at selected steps are also disclosed.

摘要翻译： 公开了通过改变制剂的离子强度以及具有降低的乳白色的浓缩蛋白质的组合物，例如药物组合物来降低蛋白质制剂的乳白色外观的方法。 还公开了在选择的步骤监测和/或降低盐浓度的纯化方法。

公开(公告)号：US20080154023A1

公开(公告)日：2008-06-26

申请号：US11974312

申请日：2007-10-12

申请人： Pilarin Elizabeth Nichols ,  Donna L. Luisi

发明人： Pilarin Elizabeth Nichols ,  Donna L. Luisi

IPC分类号： C07K16/00

CPC分类号： A61K39/39591

摘要： Methods for reducing the opalescent appearance of a protein preparation by modifying the ionic strength of the preparation, as well as compositions, e.g., pharmaceutical compositions, of concentrated protein with decreased opalescence are disclosed. Purification methods which monitor and/or reduce the salt concentrations at selected steps are also disclosed.

摘要翻译： 公开了通过改变制剂的离子强度以及具有降低的乳白色的浓缩蛋白质的组合物，例如药物组合物来降低蛋白质制剂的乳白色外观的方法。 还公开了在选择的步骤监测和/或降低盐浓度的纯化方法。

公开(公告)号：US20060031268A1

公开(公告)日：2006-02-09

申请号：US11225626

申请日：2005-09-13

申请人： David Shutt ,  Elizabeth Nichols

发明人： David Shutt ,  Elizabeth Nichols

IPC分类号： G06F17/30

CPC分类号： G06F17/30584

摘要： Various embodiments of the present invention are directed toward extending a federation of servers and balancing the data load of said federation of servers, in order to improve accessibility and scope of the system by moving the first backup data structure on the second server to the new server, creating a second data structure on the new server, and creating a second backup data structure for the second data structure on the second server. To balance the load, certain embodiments employ a method comprising suspending writes to the selected logical partitions, copying selected logical partitions to the new physical partition, redirecting reads and writes to the logical partitions in the new physical partition, and removing the original selected logical partitions. Alternative embodiments for balancing data load comprise the substitute steps of creating a temporary replication stream for the selected logical partitions to the new physical partition, copying selected logical partitions to the new physical partition, deconflicting inconsistencies in the logical partitions on the new physical partition, redirecting reads and writes for the selected logical partitions to the logical partitions in the new physical partition, and removing the original selected logical partitions that were copied to the new physical partition.

公开(公告)号：US20050210082A1

公开(公告)日：2005-09-22

申请号：US11125048

申请日：2005-05-09

申请人： David Shutt ,  Elizabeth Nichols

发明人： David Shutt ,  Elizabeth Nichols

IPC分类号： G06F9/50 ,  G06F12/02 ,  G06F17/30

CPC分类号： G06F17/30584

摘要： Various embodiments of the present invention are directed toward extending a federation of servers and balancing the data load of said federation of servers, in order to improve accessibility and scope of the system by moving the first backup data structure on the second server to the new server, creating a second data structure on the new server, and creating a second backup data structure for the second data structure on the second server. To balance the load, certain embodiments employ a method comprising suspending writes to the selected logical partitions, copying selected logical partitions to the new physical partition, redirecting reads and writes to the logical partitions in the new physical partition, and removing the original selected logical partitions. Alternative embodiments for balancing data load comprise the substitute steps of creating a temporary replication stream for the selected logical partitions to the new physical partition, copying selected logical partitions to the new physical partition, deconflicting inconsistencies in the logical partitions on the new physical partition, redirecting reads and writes for the selected logical partitions to the logical partitions in the new physical partition, and removing the original selected logical partitions that were copied to the new physical partition.

摘要翻译： 本发明的各种实施例旨在扩展服务器联合并平衡所述服务器联合的数据负载，以便通过将第二服务器上的第一备份数据结构移动到新服务器来改善系统的可访问性和范围 ，在所述新服务器上创建第二数据结构，以及在所述第二服务器上为所述第二数据结构创建第二备份数据结构。 为了平衡负载，某些实施例采用包括暂停对所选择的逻辑分区的写入的方法，将所选择的逻辑分区复制到新的物理分区，将读取和写入重定向到新的物理分区中的逻辑分区，以及去除原始选择的逻辑分区 。 用于平衡数据负载的替代实施例包括为所选择的逻辑分区创建到新的物理分区的临时复制流的复制步骤，将所选择的逻辑分区复制到新的物理分区，解除在新的物理分区上的逻辑分区中的不一致性，重定向 将所选逻辑分区读取和写入新物理分区中的逻辑分区，并删除复制到新物理分区的原始选定逻辑分区。