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1.发明申请公开(公告)号：US20090298916A1
公开(公告)日：2009-12-03
申请号：US12400625
申请日：2009-03-09
IPC分类号： A61K31/7088
CPC分类号： C12N15/113 , C12N2310/141
摘要： The present invention provides compositions and methods of treatment of diseases that are sensitive to drugs that downregulate the function of microRNA's, mRNA, non-coding RNA, or viral genomes. In particular, it has been discovered that a very long term effect of an anti microRNA oligonucleotide may be obtained when administered to a primate. Therefore, the present invention relate to pharmaceutical compositions and methods for treatment of primates, including humans wherein the compositions are administered with a long time interval.
摘要翻译： 本发明提供治疗对下调微小RNA，mRNA，非编码RNA或病毒基因组的功能的药物敏感的疾病的组合物和方法。 特别地，已经发现，当给予灵长类动物时，可以获得抗微小RNA寡核苷酸的非常长的效果。 因此，本发明涉及用于治疗灵长类动物的药物组合物和方法，包括人，其中组合物以长时间间隔施用。
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公开(公告)号：US08361980B2
公开(公告)日：2013-01-29
申请号：US12400625
申请日：2009-03-09
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N2310/141
摘要： The present invention provides compositions and methods of treatment of diseases that are sensitive to drugs that downregulate the function of microRNA's, mRNA, non-coding RNA, or viral genomes. In particular, it has been discovered that a very long term effect of an anti microRNA oligonucleotide may be obtained when administered to a primate. Therefore, the present invention relate to pharmaceutical compositions and methods for treatment of primates, including humans wherein the compositions are administered with a long time interval.
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3.发明申请公开(公告)号：US20110077288A1
公开(公告)日：2011-03-31
申请号：US12921339
申请日：2009-03-09
CPC分类号： C12N15/113 , C12N2310/141
摘要： The present invention provides compositions and methods of treatment of diseases that are sensitive to drugs that downregulate the function of microRNA's, mRNA, non-coding RNA, or viral genomes. In particular, it has been discovered that a very long term effect of an anti microRNA oligonucleotide may be obtained when administered to a primate. Therefore, the present invention relate to pharmaceutical compositions and methods for treatment of primates, including humans wherein the compositions are administered with a long time interval.
摘要翻译： 本发明提供治疗对下调微小RNA，mRNA，非编码RNA或病毒基因组的功能的药物敏感的疾病的组合物和方法。 特别地，已经发现，当给予灵长类动物时，可以获得抗微小RNA寡核苷酸的非常长的效果。 因此，本发明涉及用于治疗灵长类动物的药物组合物和方法，包括人，其中组合物以长时间间隔施用。
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