公开(公告)号：US06518465B2

公开(公告)日：2003-02-11

申请号：US09976764

申请日：2001-10-13

申请人： Craig Alan Hoyme ,  Edwin Franklin Holcombe, III

发明人： Craig Alan Hoyme ,  Edwin Franklin Holcombe, III

IPC分类号： C07C4100

CPC分类号： C07C41/01 ,  B01D3/009 ,  C07C51/09 ,  Y02P20/127 ,  C07C53/08 ,  C07C43/043

摘要： A process for hydrolyzing an alkyl ester to produce a carboxylic acid product and an ether product, the process includes the steps of introducing into a reaction zone of a reactive distillation column a feed containing the alkyl ester wherein the reaction zone is at a temperature and pressure to preferentially produce an ether from the ester; and recovering the ether and the carboxylic acid.

公开(公告)号：US06248923B1

公开(公告)日：2001-06-19

申请号：US09520526

申请日：2000-03-08

申请人： Robert Lin ,  Robert Thomas Hembre ,  Edwin Franklin Holcombe, III ,  Mark Robert Shelton

发明人： Robert Lin ,  Robert Thomas Hembre ,  Edwin Franklin Holcombe, III ,  Mark Robert Shelton

IPC分类号： C07C5154

CPC分类号： C07C51/567 ,  C07C51/56 ,  C07C51/573 ,  Y02P20/127 ,  C07C53/18

摘要： Disclosed is process for the production of symmetrical fluoro-substituted anhydrides from mixed or unsymmetrical anhydrides, i.e., wherein the two carboxylic acid acyl groups of the anhydrides are different, by subjecting an unsymmetrical anhydrides to reactive distillation to produce a lower boiling product comprising a symmetrical fluorocarboxylic acid anhydride and a higher boiling product comprising a second symmetrical anhydride. The process is particularly useful for the coproduction of trifluoroacetic anhydride (TFAA) and acetic anhydride (Ac2O) from ketene and trifluoroacetic acid wherein ketene and trifluoroacetic acid (TFA) are reacted to produce a mixed anhydride, acetyl trifluoroacetate (Ac-TFA), which then is subjected to reactive distillation to produce a vapor product comprising TFAA and a liquid product comprising Ac2O.

摘要翻译： 公开了从混合或不对称酸酐生产对称氟取代的酸酐的方法，即其中酸酐的两个羧酸酰基不同，通过使不对称酸酐进行反应蒸馏以产生包含对称的 氟代羧酸酐和包含第二对称酸酐的较高沸点产物。 该方法对于从乙烯酮和三氟乙酸共聚产生三氟乙酸酐（TFAA）和乙酸酐（Ac 2 O）特别有用，其中乙烯酮和三氟乙酸（TFA）反应以产生混合酸酐，乙酰基三氟乙酸酯（Ac-TFA），其中 然后进行反应蒸馏以产生包含TFAA和包含Ac 2 O的液体产物的蒸气产物。

公开(公告)号：US06218555B1

公开(公告)日：2001-04-17

申请号：US09543950

申请日：2000-04-06

申请人： Robert Thomas Hembre ,  Edwin Franklin Holcombe, III ,  Robert Lin ,  Mark Robert Shelton

发明人： Robert Thomas Hembre ,  Edwin Franklin Holcombe, III ,  Robert Lin ,  Mark Robert Shelton

IPC分类号： C07C5300

CPC分类号： C07C303/06 ,  C07C67/08 ,  C07C69/017 ,  C07C309/42 ,  C07C69/24

摘要： Disclosed is a process for the preparation of alkanoate esters of hydroxybenzenesulfonic acids and salts thereof by the steps of (1) contacting or reacting phenol with an alkanoic acid in the presence of trifluoroacetic acid (TFA) and trifluoroacetic anhydride (TFAA) to produce a aryl alkanoate ester and (2) contacting the reaction mixture of step (1) with a sulfonating agent to convert the aryl alkanoate ester to an alkanoate ester of hydroxybenzenesulfonic acid. The process provides the economic advantage inherent in using the product of esterification of step (1) without Disolation in the sulfonation of step (2).

摘要翻译： 公开了通过以下步骤制备羟基苯磺酸的链烷酸酯及其盐的方法：（1）在三氟乙酸（TFA）和三氟乙酸酐（TFAA）存在下使苯酚与烷酸接触或反应，生成芳基 链烷酸酯和（2）使步骤（1）的反应混合物与磺化剂接触以将芳基链烷酸酯转化为羟基苯磺酸的链烷酸酯。 该方法提供了在步骤（2）的磺化中使用步骤（1）的酯化产物而没有分离的固有的经济优点。