公开(公告)号：US5945002A

公开(公告)日：1999-08-31

申请号：US705624

申请日：1996-08-30

申请人： Winston Daniel Leukes ,  Edmund Petrus Jacobs ,  Peter Dale Rose ,  Stephanie Gail Burton ,  Ronald Douglas Sanderson

发明人： Winston Daniel Leukes ,  Edmund Petrus Jacobs ,  Peter Dale Rose ,  Stephanie Gail Burton ,  Ronald Douglas Sanderson

IPC分类号： C02F3/10 ,  C02F3/34 ,  B01D61/00

CPC分类号： C02F3/102 ,  C02F3/34 ,  Y02W10/15

摘要： A method of producing a secondary metabolites comprises providing a porous substratum which has a biofilm of micro-organism attached thereto, and causing a nutrient solution to flow through the substratum, at a rate which is sufficiently low for a nutrient gradient to be established across the biofilm, such that the nutrient concentration at a high level along the gradient is sufficiently high to support primary growth of the micro-organism, and the nutrient concentration at low level along the gradient being sufficiently low to induce secondary growth of the micro-organism, thereby to produce secondary metabolite. The substrate is in the form of a hollow fibre membrane having a relatively thin, porous skin on the inside, and a relatively thick, finger-like, externally unskinned void structure radiating outwardly from the skin.

摘要翻译： 生产次级代谢物的方法包括提供多孔底物，其具有附着于其上的微生物生物膜，并使营养液以足够低的速率流过基质，以便跨越所述营养梯度建立营养梯度 生物膜，使得沿着梯度的高水平的营养物浓度足够高以支持微生物的初级生长，并且沿梯度的低水平的营养物浓度足够低以诱导微生物的二次生长， 从而产生次生代谢物。 衬底是中空纤维膜的形式，其在内部具有相对薄的多孔皮肤，以及从皮肤向外辐射的相对较厚的手指状的外部非光滑的空隙结构。

公开(公告)号：US5833896A

公开(公告)日：1998-11-10

申请号：US659744

申请日：1996-06-06

申请人： Edmund Petrus Jacobs ,  Ronald Douglas Sanderson

发明人： Edmund Petrus Jacobs ,  Ronald Douglas Sanderson

IPC分类号： B01D67/00 ,  B01D69/08 ,  C12N11/08 ,  D01D5/24 ,  D01D5/247

CPC分类号： D01D5/24 ,  B01D67/0009 ,  B01D67/0016 ,  B01D69/08 ,  B01D69/087 ,  C12N11/08 ,  B01D2323/12

摘要： A method of making a hollow fiber membrane comprises extruding a membrane-forming polymer solution through the annulus of a tube-in-orifice spinneret (12) to form a nascent hollow membrane (32), there being a lumen coagulant in the lumen of the nascent membrane, and the outside of the nascent membrane being contacted with an external coagulant (34). The external coagulant has a solvent content which is such that, at the interface between the nascent membrane and the external coagulant, liquid--liquid phase separation rather than gelation is thermodynamically the favored process, and the membrane is then subjected to a vapor-phase non-solvent environment to induce precipitation of the phase-separated polymer.

摘要翻译： 制造中空纤维膜的方法包括通过管孔喷丝板（12）的环状物挤出成膜聚合物溶液以形成新生中空膜（32），在内腔中存在管腔凝结剂 新生膜，并且新生膜的外部与外部凝结剂（34）接触。 外部凝结剂的溶剂含量使得在新生膜和外部凝结剂之间的界面处，液 - 液相分离而不是凝胶化是热力学上的有利方法，然后将膜进行气相非 溶剂环境诱发相分离聚合物沉淀。