公开(公告)号：US20210139429A1

公开(公告)日：2021-05-13

申请号：US17042616

申请日：2019-03-28

Applicant: ELEX BIOTECH, INC.

Inventor： Josephrajan THAINASHMUTHU ,  Martha SIBRIAN-VAZQUEZ ,  Douglas BOATMAN

IPC: C07D213/74 ,  C07C309/24 ,  C07C217/88 ,  C07D271/06 ,  C07D295/13 ,  C07D257/04 ,  C07D217/04 ,  C07D231/56 ,  C07D215/12 ,  C07C211/49 ,  C07D209/44 ,  C07C229/64 ,  A61P9/06 ,  A61P9/04

Abstract: This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof.

公开(公告)号：US11427542B2

公开(公告)日：2022-08-30

申请号：US17042616

申请日：2019-03-28

Applicant: Elex Biotech, Inc.

Inventor： Josephrajan Thainashmuthu ,  Martha Sibrian-Vazquez ,  Douglas Boatman

IPC: C07C211/49 ,  C07C217/88 ,  C07D213/74 ,  A61P9/06 ,  A61P9/04 ,  C07C229/64 ,  C07C309/24 ,  C07D209/44 ,  C07D215/12 ,  C07D217/04 ,  C07D231/56 ,  C07D257/04 ,  C07D271/06 ,  C07D295/13

Abstract: This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof.