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1.发明授权Methods of detecting oxidized calcium/calmodulin dependent protein kinase II 有权检测氧化钙/钙调蛋白依赖性蛋白激酶II的方法公开(公告)号：US09090701B2
公开(公告)日：2015-07-28
申请号：US13605341
申请日：2012-09-06
IPC分类号： C07K16/40 , C07K16/44 , G01N33/573 , A61P25/28 , G01N33/574
CPC分类号： C07K16/40 , C07K16/44 , G01N33/57484 , G01N2800/26 , G01N2800/2821 , G01N2800/32
摘要： Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.
摘要翻译： 已经发现钙/钙调素依赖性蛋白激酶II（CaMKII）被直接氧化，并观察到CaMKII的直接氧化导致CaMKII的钙独立活化。 产生与氧化形式的CaMKII（oxCaMKII）特异性结合的抗体，并用于检测血液中的oxCaMKII：（1）具有癌症的小鼠; （2）敲除编码甲硫氨酸亚砜还原酶的基因的小鼠; （3）注射血管紧张素II的小鼠; （4）注射细菌内毒素的小鼠; （5）饲喂促氧化（酮生成）饮食的小鼠; 和（6）已经用实验治疗的癌症小鼠。
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2.发明申请Kits for Detecting Direct Oxidation of Calcium/Calmodulin Dependent Protein Kinase II and Associated Diagnostic and Therapeutic Methods 有权用于检测钙/钙调蛋白依赖性蛋白激酶II的直接氧化的试剂盒及相关诊断和治疗方法公开(公告)号：US20130012568A1
公开(公告)日：2013-01-10
申请号：US13605341
申请日：2012-09-06
IPC分类号： G01N33/573 , A61P35/00 , A61P25/28 , A61K31/7088 , A61P9/00
CPC分类号： C07K16/40 , C07K16/44 , G01N33/57484 , G01N2800/26 , G01N2800/2821 , G01N2800/32
摘要： Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.
摘要翻译： 已经发现钙/钙调素依赖性蛋白激酶II（CaMKII）被直接氧化，并观察到CaMKII的直接氧化导致CaMKII的钙独立活化。 产生与氧化形式的CaMKII（oxCaMKII）特异性结合的抗体，并用于检测血液中的oxCaMKII：（1）具有癌症的小鼠; （2）敲除编码甲硫氨酸亚砜还原酶的基因的小鼠; （3）注射血管紧张素II的小鼠; （4）注射细菌内毒素的小鼠; （5）饲喂促氧化（酮生成）饮食的小鼠; 和（6）已经用实验治疗的癌症小鼠。
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3.发明申请Direct Oxidation of Calcium/Calmodulin Dependent Protein Kinase II and Associated Diagnostic and Therapeutic Methods 有权钙/钙调蛋白依赖性蛋白激酶II的直接氧化和相关的诊断和治疗方法公开(公告)号：US20100226929A1
公开(公告)日：2010-09-09
申请号：US12430644
申请日：2009-04-27
IPC分类号： A61K39/395 , C07K16/40 , C07K17/00 , C12N9/12 , C12N5/10 , G01N33/573 , A61P9/00
CPC分类号： C07K16/40 , C07K16/44 , G01N33/57484 , G01N2800/26 , G01N2800/2821 , G01N2800/32
摘要： Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.
摘要翻译： 已经发现钙/钙调素依赖性蛋白激酶II（CaMKII）被直接氧化，并观察到CaMKII的直接氧化导致CaMKII的钙独立活化。 产生与氧化形式的CaMKII（oxCaMKII）特异性结合的抗体，并用于检测血液中的oxCaMKII：（1）具有癌症的小鼠; （2）敲除编码甲硫氨酸亚砜还原酶的基因的小鼠; （3）注射血管紧张素II的小鼠; （4）注射细菌内毒素的小鼠; （5）饲喂促氧化（酮生成）饮食的小鼠; 和（6）已经用实验治疗的癌症小鼠。
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4.发明授权Monoclonal antibodies specific for oxidized calcium/calmodulin dependent protein kinase II 有权氧化钙/钙调蛋白依赖性蛋白激酶II特异性单克隆抗体公开(公告)号：US08841423B2
公开(公告)日：2014-09-23
申请号：US12430644
申请日：2009-04-27
IPC分类号： C07K16/44 , A61K39/395 , G01N33/574 , C07K16/40
CPC分类号： C07K16/40 , C07K16/44 , G01N33/57484 , G01N2800/26 , G01N2800/2821 , G01N2800/32
摘要： Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.
摘要翻译： 已经发现钙/钙调素依赖性蛋白激酶II（CaMKII）被直接氧化，并观察到CaMKII的直接氧化导致CaMKII的钙独立活化。 产生与氧化形式的CaMKII（oxCaMKII）特异性结合的抗体，并用于检测血液中的oxCaMKII：（1）具有癌症的小鼠; （2）敲除编码甲硫氨酸亚砜还原酶的基因的小鼠; （3）注射血管紧张素II的小鼠; （4）注射细菌内毒素的小鼠; （5）饲喂促氧化（酮生成）饮食的小鼠; 和（6）已经用实验治疗的癌症小鼠。
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