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公开(公告)号：US10336689B1
公开(公告)日：2019-07-02
申请号：US16359963
申请日：2019-03-20
申请人： Chengyuan Liang , Shunjun Ding , Nan Hui , Juan Li , Dezhu Zhang , Xiaolin Xie
发明人： Chengyuan Liang , Shunjun Ding , Nan Hui , Juan Li , Dezhu Zhang , Xiaolin Xie
IPC分类号： C07C251/24 , A61P35/00 , C07C249/02
摘要： A gossypol eflornithine Schiff base compound having the following Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed.
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公开(公告)号：US09975849B1
公开(公告)日：2018-05-22
申请号：US15798877
申请日：2017-10-31
申请人： Xiaolin Xie , Dezhu Zhang , Chengyuan Liang , Lei Tian , Shunjun Ding , Xingke Ju
发明人： Xiaolin Xie , Dezhu Zhang , Chengyuan Liang , Lei Tian , Shunjun Ding , Xingke Ju
IPC分类号： C07C279/14 , C07C277/08
CPC分类号： C07C279/14 , C07B2200/07 , C07B2200/13 , C07C277/08
摘要： A compound with antitumor activities is represented by formula I: A method of preparing the compound of formula I is also disclosed.
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公开(公告)号：US10722500B2
公开(公告)日：2020-07-28
申请号：US16270563
申请日：2019-02-07
申请人： Xiaolin Xie , Dezhu Zhang , Shunjun Ding , Chengyuan Liang
发明人： Xiaolin Xie , Dezhu Zhang , Shunjun Ding , Chengyuan Liang
IPC分类号： A61K31/437 , A61P35/00 , G01N33/50
摘要： A gossypol 7-N-isatin Schiff base compounds compound with antitumor activities represented by formula I: is disclosed. In formula I, R is hydrogen, alkyl, cycloalkyl, alkoxy, unsubstituted or substituted phenyl, or substituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.
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4.发明授权公开(公告)号：US10858312B1
公开(公告)日：2020-12-08
申请号：US16939766
申请日：2020-07-27
申请人： Xiaolin Xie , Dezhu Zhang , Zhong Meng , Jianguo Meng , Yu Wang , Shunjun Ding , Chengyuan Liang , Liang Xin , Jingyi Li , Jiayun Zhang , Kangxiong Wu , Juan Xia , Han Li
发明人： Xiaolin Xie , Dezhu Zhang , Zhong Meng , Jianguo Meng , Yu Wang , Shunjun Ding , Chengyuan Liang , Liang Xin , Jingyi Li , Jiayun Zhang , Kangxiong Wu , Juan Xia , Han Li
IPC分类号： C07C271/02 , C07C269/06
摘要： A compound of Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed. R is alkyl, haloalkyl, aryl, or substituted aryl. Preferably, R is —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH2CH2CH3, —CF3, —CHF2, —CH2CF3,
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公开(公告)号：US20200376056A1
公开(公告)日：2020-12-03
申请号：US16993599
申请日：2020-08-14
申请人： Xiaolin XIE , Dezhu ZHANG , Jianguo MENG , Yu WANG , Xuhua ZHOU , Zhong MENG , Nan HUI , Juan LI
发明人： Xiaolin XIE , Dezhu ZHANG , Jianguo MENG , Yu WANG , Xuhua ZHOU , Zhong MENG , Nan HUI , Juan LI
摘要： A method for extracting herbal medicine includes: step one, spray extraction; step two, pressure filtration and concentration; step three, spray and countercurrent precipitation; and step four, concentrating reduced pressure and drying.
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6.发明授权公开(公告)号：US09758503B1
公开(公告)日：2017-09-12
申请号：US15489711
申请日：2017-04-17
申请人： Chengyuan Liang , Danni Tian , Minyi Jia , Xuechuan Wang , Xiaolin Xie , Dezhu Zhang
发明人： Chengyuan Liang , Danni Tian , Minyi Jia , Xuechuan Wang , Xiaolin Xie , Dezhu Zhang
IPC分类号： C07D311/56
CPC分类号： C07D311/56
摘要： A compound with antitumor activities is represented by formula A or formula B R1, R2, R3, and R4 are independently hydrogen, hydroxyl, alkoxy, halogen, formyl, unsubstituted or substituted alkyl, or unsubstituted or substituted cycloalkyl.
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公开(公告)号：US11219652B2
公开(公告)日：2022-01-11
申请号：US16993599
申请日：2020-08-14
申请人： Xiaolin Xie , Dezhu Zhang , Jianguo Meng , Yu Wang , Xuhua Zhou , Zhong Meng , Nan Hui , Juan Li
发明人： Xiaolin Xie , Dezhu Zhang , Jianguo Meng , Yu Wang , Xuhua Zhou , Zhong Meng , Nan Hui , Juan Li
摘要： A method for extracting herbal medicine includes: step one, spray extraction; step two, pressure filtration and concentration; step three, spray and countercurrent precipitation; and step four, concentrating reduced pressure and drying.
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8.发明申请公开(公告)号：US20200147057A1
公开(公告)日：2020-05-14
申请号：US16270563
申请日：2019-02-07
申请人： Xiaolin XIE , Dezhu ZHANG , Shunjun DING , Chengyuan LIANG
发明人： Xiaolin XIE , Dezhu ZHANG , Shunjun DING , Chengyuan LIANG
IPC分类号： A61K31/437 , A61P35/00 , G01N33/50
摘要： A gossypol 7-N-isatin Schiff base compounds compound with antitumor activities represented by formula I: is disclosed. In formula I, R is hydrogen, alkyl, cycloalkyl, alkoxy, unsubstituted or substituted phenyl, or substituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.
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公开(公告)号：US11712457B2
公开(公告)日：2023-08-01
申请号：US17173622
申请日：2021-02-11
申请人： Qianqian Zhao , Jialin Li , Dan Yang , Jingyi Li , Liang Xin , Chunyang Shi , Xiaolin Xie , Dezhu Zhang , Ruina Bian , Xingke Ju , Chengyuan Liang , Yanjun Li , Qiao Zeng
发明人： Qianqian Zhao , Jialin Li , Dan Yang , Jingyi Li , Liang Xin , Chunyang Shi , Xiaolin Xie , Dezhu Zhang , Ruina Bian , Xingke Ju , Chengyuan Liang , Yanjun Li , Qiao Zeng
IPC分类号： A61K36/63 , A61P31/04 , A61K47/44 , A61K31/7034 , A61K31/7048
CPC分类号： A61K36/63 , A61K31/7034 , A61K31/7048 , A61K47/44 , A61P31/04 , A61K2236/15 , A61K2236/333 , A61K2236/35 , A61K2236/37 , A61K2236/51 , A61K2236/53
摘要： A Syringa microphylla seed extract includes the following components by weight based on a total weight of the Syringa microphylla seed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing the Syringa microphylla seed extract is disclosed. A composition for treating antibiotic-resistant infections that includes the Syringa microphylla seed extract is also disclosed.
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10.发明申请公开(公告)号：US20220160805A1
公开(公告)日：2022-05-26
申请号：US17173622
申请日：2021-02-11
申请人： Dan YANG , Jingyi LI , Liang XIN , Chunyang SHI , Xiaolin XIE , Dezhu ZHANG , Ruina BIAN , Xingke JU , Chengyuan LIANG , Yanjun LI , Qiao ZENG
发明人： Dan YANG , Jingyi LI , Liang XIN , Chunyang SHI , Xiaolin XIE , Dezhu ZHANG , Ruina BIAN , Xingke JU , Chengyuan LIANG , Yanjun LI , Qiao ZENG
IPC分类号： A61K36/63 , A61K31/7034 , A61K31/7048 , A61K47/44 , A61P31/04
摘要： A Syringa microphylla seed extract includes the following components by weight based on a total weight of the Syringa microphylla seed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing the Syringa microphylla seed extract is disclosed. A composition for treating antibiotic-resistant infections that includes the Syringa microphylla seed extract is also disclosed.
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