Characterization and use of an isolated uridine diphospho-glucuronosyltransferase
    1.
    发明授权
    Characterization and use of an isolated uridine diphospho-glucuronosyltransferase 失效
    分离的尿苷二磷酸 - 葡萄糖醛酸基转移酶的表征和使用

    公开(公告)号:US06287834B1

    公开(公告)日:2001-09-11

    申请号:US09180852

    申请日:1999-02-08

    CPC classification number: C12N9/1051 A61K38/00 A61K48/00

    Abstract: A uridine diphospho-glucuronosyltransferase (UGTB217) is provided. Methods of producing the enzyme and using the enzyme to identify potential compounds which inhibit or alter the activity of the enzyme are described. In addition, methods of using antibodies to localize the protein, or using the gene sequence or portions thereof for probes or using the gene sequence to produce expression-disrupting sense or antisense DNA fragments thereof, or antisense RNA, are provided.

    Abstract translation: 提供尿苷二磷酸 - 葡萄糖醛酸基转移酶(UGTB217)。 描述了生产酶并使用该酶鉴定抑制或改变酶的活性的潜在化合物的方法。 此外,提供了使用抗体来定位蛋白质的方法,或者使用基因序列或其部分用于探针或使用基因序列产生表达破坏其有义或反义DNA片段或反义RNA的方法。

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