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公开(公告)号：US09289492B2
公开(公告)日：2016-03-22
申请号：US12669136
申请日：2008-07-17
申请人： Patricia K Donahoe , Paul P Szotek , David T MacLaughlin , Frederic Preffer , Rafael Pieretti-Vanmarcke , David Michael Dombkowski
发明人： Patricia K Donahoe , Paul P Szotek , David T MacLaughlin , Frederic Preffer , Rafael Pieretti-Vanmarcke , David Michael Dombkowski
IPC分类号： C12N5/00 , A61K45/06 , A61K31/00 , A61K31/277 , A61K31/7088 , C12N5/095 , G01N33/50 , G01N33/574 , C12N5/071
CPC分类号： A61K45/06 , A61K31/00 , A61K31/277 , A61K31/7088 , C12N5/0672 , C12N5/0695 , C12N2501/998 , C12N2503/00 , C12N2503/02 , G01N33/5011 , G01N33/5091 , G01N33/57449 , G01N2800/44 , G01N2800/54
摘要： The present invention relates to compositions and methods for treating, characterizing and diagnosing ovarian cancer. In particular, the present invention provides methods for treating and/or preventing ovarian cancer in a subject by administering to the subject an effective amount of Mullerian Inhibiting substance and/or an effective amount of an agent that inhibits BCRP1. The present invention further provides methods to identify and/or enrich for populations of ovarian cancer stem cells and populations of somatic ovarian stem cells, in particular, enrichment for populations of coelomic somatic ovarian stem cells, subcoelomic/stromal somatic ovarian stem cells and periphilar medullary somatic ovarian stem cells. The present invention also provides somatic ovarian stem cell markers and ovarian cancer stem cell markers, as well as methods to identify agents which selectively inhibit the proliferation of ovarian cancer stem cells as compared to somatic ovarian stem cells.
摘要翻译： 本发明涉及用于治疗，表征和诊断卵巢癌的组合物和方法。 特别地，本发明提供了通过向受试者施用有效量的Mullerian抑制物质和/或有效量的抑制BCRP1的药剂来治疗和/或预防受试者的卵巢癌的方法。 本发明还提供了用于鉴定和/或丰富卵巢癌干细胞和体细胞卵巢干细胞群体的方法，特别是对于体细胞性体细胞卵巢干细胞，亚骨髓/间质体细胞卵巢干细胞和腹膜髓质细胞的群体的富集 体细胞卵巢干细胞。 本发明还提供体细胞卵巢干细胞标记物和卵巢癌干细胞标记物，以及与体细胞卵巢干细胞相比选择性抑制卵巢癌干细胞增殖的试剂的方法。
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2.发明申请公开(公告)号：US20100273160A1
公开(公告)日：2010-10-28
申请号：US12669136
申请日：2008-07-17
申请人： Patricia K. Donahoe , Paul P. Szotek , David T. MacLaughlin , Frederic Preffer , Rafael Pieretti-Vanmarcke , David Michael Dombkowski
发明人： Patricia K. Donahoe , Paul P. Szotek , David T. MacLaughlin , Frederic Preffer , Rafael Pieretti-Vanmarcke , David Michael Dombkowski
CPC分类号： A61K45/06 , A61K31/00 , A61K31/277 , A61K31/7088 , C12N5/0672 , C12N5/0695 , C12N2501/998 , C12N2503/00 , C12N2503/02 , G01N33/5011 , G01N33/5091 , G01N33/57449 , G01N2800/44 , G01N2800/54
摘要： The present invention relates to compositions and methods for treating, characterizing and diagnosing ovarian cancer. In particular, the present invention provides methods for treating and/or preventing ovarian cancer in a subject by administering to the subject an effective amount of Mullerian Inhibiting substance and/or an effective amount of an agent that inhibits BCRP1. The present invention further provides methods to identify and/or enrich for populations of ovarian cancer stem cells and populations of somatic ovarian stem cells, in particular, enrichment for populations of coelomic somatic ovarian stem cells, subcoelomic/stromal somatic ovarian stem cells and periphilar medullary somatic ovarian stem cells. The present invention also provides somatic ovarian stem cell markers and ovarian cancer stem cell markers, as well as methods to identify agents which selectively inhibit the proliferation of ovarian cancer stem cells as compared to somatic ovarian stem cells.
摘要翻译： 本发明涉及用于治疗，表征和诊断卵巢癌的组合物和方法。 特别地，本发明提供了通过向受试者施用有效量的Mullerian抑制物质和/或有效量的抑制BCRP1的药剂来治疗和/或预防受试者的卵巢癌的方法。 本发明还提供了用于鉴定和/或丰富卵巢癌干细胞和体细胞卵巢干细胞群体的方法，特别是对于体细胞性体细胞卵巢干细胞，亚骨髓/间质体细胞卵巢干细胞和腹膜髓质细胞的群体的富集 体细胞卵巢干细胞。 本发明还提供体细胞卵巢干细胞标记物和卵巢癌干细胞标记物，以及与体细胞卵巢干细胞相比选择性抑制卵巢癌干细胞增殖的试剂的方法。
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