公开(公告)号：US08853194B2

公开(公告)日：2014-10-07

申请号：US13387559

申请日：2010-01-15

申请人： Dagang Chen ,  Haimin Lei

发明人： Dagang Chen ,  Haimin Lei

IPC分类号： A61K31/58 ,  C07J71/00

CPC分类号： C07J71/0005 ,  C07J9/00

摘要： Sterol derivatives with structural formula I or II are disclosed, wherein R is defined as the description of the invention. Their synthesizing methods and anti-tumor use are also disclosed. Especially, the compound of formula I, in which R is O (i.e. the compound CL 168-6), has the anti-tumor therapeutic index of 49.3. The compound can be used to prepare a medicine for prevention or treatment of immunological diseases and cancers such as liver cancer and lung cancer.

摘要翻译： 公开了具有结构式I或II的甾醇衍生物，其中R定义为本发明的描述。 还公开了它们的合成方法和抗肿瘤用途。 特别是其中R为O的式I化合物（即化合物CL 168-6）的抗肿瘤治疗指数为49.3。 该化合物可用于制备预防或治疗免疫疾病和癌症如肝癌和肺癌的药物。

公开(公告)号：US20100017888A1

公开(公告)日：2010-01-21

申请号：US12566874

申请日：2009-09-25

申请人： Renzhou ZHANG ,  Pei DANG ,  Zhipeng ZHOU ,  Dagang CHEN ,  Haojun ZHOU ,  Chen HUANG ,  Wenjie FENG

发明人： Renzhou ZHANG ,  Pei DANG ,  Zhipeng ZHOU ,  Dagang CHEN ,  Haojun ZHOU ,  Chen HUANG ,  Wenjie FENG

IPC分类号： G06F7/00

CPC分类号： G06F21/10 ,  G06F2221/0706

摘要： The present invention discloses a method for transferring licenses, a device for issuing licenses, and a communication system, and relates to the Digital Rights Management (DRM) technology. The method includes: the first issuing device receives a request of transferring a license issued by the second issuing device; the first issuing device transfers the license after determining that a relationship is set up with the second issuing device. The license issuing device includes: a receiving module, a setup module, a determining module, and a sending module. The communication system includes: a first issuing device, a second issuing device, and a device requesting to transfer a license. Through the present invention, an issuing device may transfer the licenses issued by other issuing devices, thus improving the flexibility of transferring the licenses.

摘要翻译： 本发明公开了一种用于传送许可证的方法，用于发行许可证的设备和通信系统，并涉及数字版权管理（DRM）技术。 该方法包括：第一发行装置接收由第二发行装置发出的许可证的转让请求; 第一发行装置在确定与第二发行装置建立关系之后传送许可证。 许可证发行装置包括：接收模块，设置模块，确定模块和发送模块。 通信系统包括：第一发行装置，第二发行装置和请求转移许可证的装置。 通过本发明，发行装置可以转让由其他发行装置发行的许可证，从而提高转让许可证的灵活性。

公开(公告)号：US20090158440A1

公开(公告)日：2009-06-18

申请号：US12391697

申请日：2009-02-24

申请人： Pei Dang ,  Yimin Li ,  Renzhou Zhang ,  Haojun Zhou ,  Wenjie Feng ,  Chen Zhou ,  Zhipeng Zhou ,  Chen Huang ,  Dagang Chen

发明人： Pei Dang ,  Yimin Li ,  Renzhou Zhang ,  Haojun Zhou ,  Wenjie Feng ,  Chen Zhou ,  Zhipeng Zhou ,  Chen Huang ,  Dagang Chen

IPC分类号： G06F21/00

CPC分类号： H04L63/10 ,  G06F21/10 ,  H04L2463/101

摘要： A method for exporting permission is provided to solves the problem that the permission can not be exported multiple times among several DRM systems in the prior art; the method includes that: determining that a license is permitted to be exported to a system that a target device belongs to; determining whether an export permission in the license is permitted to be exported; and exporting the export permission in the license to the target device if the export permission in the license is permitted to be exported, which enables the target device to export the license to another device. A terminal apparatus, a server and a communication network are also disclosed.

摘要翻译： 提供了一种用于导出权限的方法，以解决在现有技术中的若干DRM系统中许可不能多次导出的问题; 该方法包括：确定许可证被允许导出到目标设备所属的系统; 确定许可证中的出口许可是否被允许出口; 并且如果允许导出许可证中的导出许可，则将许可证中的导出许可导出到目标设备，这使得目标设备能够将许可证导出到另一个设备。 还公开了终端装置，服务器和通信网络。

公开(公告)号：US20080051560A1

公开(公告)日：2008-02-28

申请号：US11736504

申请日：2007-04-17

申请人： Michael Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana Aswad

发明人： Michael Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana Aswad

IPC分类号： C07K16/00

CPC分类号： C07K16/40 ,  C12N9/1003

摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。

公开(公告)号：US20050176092A1

公开(公告)日：2005-08-11

申请号：US10830591

申请日：2004-04-22

申请人： Michael Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana Aswad

发明人： Michael Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana Aswad

IPC分类号： C12N9/10 ,  C12P21/06

CPC分类号： C07K16/40 ,  C12N9/1003

摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。

公开(公告)号：US20100067529A1

公开(公告)日：2010-03-18

申请号：US12607966

申请日：2009-10-28

申请人： Dagang Chen ,  Haifeng Duan ,  Yimin Li

发明人： Dagang Chen ,  Haifeng Duan ,  Yimin Li

IPC分类号： H04J3/22 ,  H04L12/56

CPC分类号： H04L69/18 ,  H04L51/066 ,  H04L67/2823 ,  H04L69/08

摘要： A message processing method, device, and system are provided in the embodiments of the present invention. The method comprises: receiving service messages and identifying the protocol type of the service messages; performing protocol adaptation according to the protocol type; and reconstructing the content of the service messages after protocol adaptation according to the corresponding content reconstructing policies and sending the service messages after content reconstructing. The present invention implements information embedment into the content over different protocols without proxy server settings.

摘要翻译： 在本发明的实施例中提供了消息处理方法，设备和系统。 该方法包括：接收服务消息并识别服务消息的协议类型; 根据协议类型执行协议适配; 并根据相应的内容重构策略重构协议适配后的业务消息内容，并在内容重构后发送业务消息。 本发明通过不同的代理服务器设置将信息嵌入到内容中。

公开(公告)号：US08326262B2

公开(公告)日：2012-12-04

申请号：US12545941

申请日：2009-08-24

申请人： Haifeng Duan ,  Yimin Li ,  Dagang Chen

发明人： Haifeng Duan ,  Yimin Li ,  Dagang Chen

IPC分类号： H04M11/00

CPC分类号： H04L12/14 ,  H04L12/1403 ,  H04L12/1414 ,  H04M15/83 ,  H04M2215/82

摘要： An advice of charging (AoC) method, system, and mobile terminal thereof are provided. The method includes receiving AoC information sent by a service charging server, and then displaying the AoC information. The mobile terminal includes a receiving module adapted to receive AoC information sent by a service charging server, and a display module adapted to display the received AoC information. The system includes a terminal, a service charging server, a service gateway, and a charging engine. The present invention is applicable to pre-consumption prompt, post-consumption notification, and prompts for data services such as browsing, streaming media, and mail.

摘要翻译： 提供了充电（AoC）方法，系统和移动终端的建议。 该方法包括接收由服务计费服务器发送的AoC信息，然后显示AoC信息。 移动终端包括适于接收由服务计费服务器发送的AoC信息的接收模块和适于显示所接收的AoC信息的显示模块。 系统包括终端，业务计费服务器，业务网关和计费引擎。 本发明适用于消费前消费提示，消费后通知，以及诸如浏览，流媒体和邮件等数据服务的提示。

公开(公告)号：US08247168B2

公开(公告)日：2012-08-21

申请号：US12573066

申请日：2009-10-02

申请人： Michael R. Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana W. Aswad

发明人： Michael R. Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana W. Aswad

IPC分类号： C12Q1/48 ,  C12Q1/68 ,  C12N9/10

CPC分类号： C07K16/40 ,  C12N9/1003

摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。

公开(公告)号：US20120130067A1

公开(公告)日：2012-05-24

申请号：US13387559

申请日：2010-01-15

申请人： Dagang Chen ,  Haimin Lei

发明人： Dagang Chen ,  Haimin Lei

IPC分类号： C07J71/00 ,  C07J75/00

CPC分类号： C07J71/0005 ,  C07J9/00

摘要： Sterol derivatives with structural formula I or II are disclosed, wherein R is defined as the description of the invention. Their synthesizing methods and anti-tumor use are also disclosed. Especially, the compound of formula I, in which R is O (i.e. the compound CL 168-6), has the anti-tumor therapeutic index of 49.3. The compound can be used to prepare a medicine for prevention or treatment of immunological diseases and cancers such as liver cancer and lung cancer.

摘要翻译： 公开了具有结构式I或II的甾醇衍生物，其中R定义为本发明的描述。 还公开了它们的合成方法和抗肿瘤用途。 特别是其中R为O的式I化合物（即化合物CL 168-6）的抗肿瘤治疗指数为49.3。 该化合物可用于制备预防或治疗免疫疾病和癌症如肝癌和肺癌的药物。

公开(公告)号：US20100092982A1

公开(公告)日：2010-04-15

申请号：US12573066

申请日：2009-10-02

申请人： MICHAEL R. STALLCUP ,  DAGANG CHEN ,  HENG HONG ,  DANA W. ASWAD

发明人： MICHAEL R. STALLCUP ,  DAGANG CHEN ,  HENG HONG ,  DANA W. ASWAD

IPC分类号： C12Q1/68

CPC分类号： C07K16/40 ,  C12N9/1003

摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。