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公开(公告)号：US20250051390A1
公开(公告)日：2025-02-13
申请号：US18718201
申请日：2022-12-09
Inventor： Jin Ho CHUNG , Eun Ju KIM , Joong Heon SUH , Ji Hoon LEE , Yoon Na KWAK , Go Ni JUNG , Sun You PARK , Myeong A CHOI , Ju Sik MIN , Ha Yeon LEE
Abstract: The present invention relates to a novel peptoid derivative and the like. The peptoid derivative is obtained by partially modifying an adiponectin receptor peptide, and has high stability and excellent p-AMPK activity, compared to existing adiponectin receptor peptides and has improved physical properties and activity, thus having the advantage of being suitable for drug formulation. Therefore, the peptoid derivative of the present invention can be used for the prevention or treatment of skin inflammatory diseases, wounds, hair loss, fibrosis, metabolic diseases, or cancer, or the prevention or amelioration of aging, sensitive skin, wrinkles, or moisturization.
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公开(公告)号：US20250049891A1
公开(公告)日：2025-02-13
申请号：US18718186
申请日：2022-12-09
Inventor： Jin Ho CHUNG , Eun Ju KIM , Joong Heon SUH , Ji Hoon LEE , Yoon Na KWAK , Go Ni JUNG , Sun You PARK , Myeong A CHOI , Ju Sik MIN , Ha Yeon LEE
IPC: A61K38/22 , C07K14/575
Abstract: The present disclosure relates to a novel peptide derivative, etc., the peptide derivative being a partially modified adiponectin receptor peptide which, compared to conventional adiponectin receptor peptides, has higher stability, superior p-AMPK activity, and improved physical properties and activity and thus offers advantages when formulated into a drug. Therefore, the peptide derivative of the present invention can be used to prevent or treat inflammatory skin diseases, wounds, hair loss, fibrosis, metabolic diseases, or cancer, to prevent or alleviate aging, sensitive skin, or wrinkles, or to enhance moisturization.
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公开(公告)号：US20220106307A1
公开(公告)日：2022-04-07
申请号：US17398478
申请日：2021-08-10
Applicant: DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Hwan Geun CHOI , Eunhwa KO , Joong-heui CHO , Jung Beom SON , Yi Kyung KO , Jin-Hee PARK , So Young KIM , Seock Yong KANG , Seungyeon LEE , Hee Yoon RYU , Nam Doo KIM , Sang Bum KIM , Sun-Hwa LEE , Dayea KIM , Sun Joo LEE , Sungchan CHO , Kyu-Sun LEE , Kweon YU , Miri CHOI , Ja Wook KOO , Hyang-Sook HOE
IPC: C07D471/04 , A61P25/28
Abstract: The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.
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公开(公告)号：US10442796B2
公开(公告)日：2019-10-15
申请号：US15998791
申请日：2018-08-16
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION
Inventor： Tae Bo Sim , Woo Young Hur , Chi Man Song , Ho Jong Yoon , Seung Hye Choi , Han Na Cho , Hwan Geun Choi , Nam Doo Kim , Jung Beom Son , Eun Hwa Ko , Hyun Kyoung Kim , Joong Heui Cho , Seock Yong Kang , So Young Kim , Yi Kyung Ko , Seung Yeon Lee , Suk Kyoon Yoon , Jae Hyun Bae
IPC: C07D409/12 , A61P35/02 , A61K31/381 , A61K31/4436 , C07D333/10 , C07D409/14
Abstract: The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.
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公开(公告)号：US20190016703A1
公开(公告)日：2019-01-17
申请号：US16066150
申请日：2016-12-29
Inventor： Nathanael S. GRAY , James BRADNER , Pasi JANNE , Jaebong JANG , Hwan Geun CHOI , Eunhwa KO , Joong-Heui CHO
IPC: C07D401/14 , A61P35/00 , A61K47/54 , A61K47/18 , A61K47/08
Abstract: The present invention provides bifunctional compounds which act as protein degradation inducing moieties for a HER family protein, such as Her3. The present invention also provides methods for the targeted degradation of a HER family protein through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to the HER family protein which can be utilized in the treatment of disorders modulated by a HER family protein.
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Patent Agency Ranking
公开(公告)号：US20240018119A1
公开(公告)日：2024-01-18
申请号：US17928044
申请日：2021-04-05
Applicant: DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION , TRINEURO
Inventor： Minsoo Song , Chun Young Im , Ga Young Park , Eun Bi Ko , Jihee Kang , Seri Bae , Soong-Hyun Kim , Yoojin Park , Eunhye Lee , Yujeong Choi , Eunju Cha , Chang Hoon Seo , Chan Young Shin , Kyoung Ja Kwon , Darine Froy Mabunga , Donghyun Park , Hee Jong Hwang , Ryeong Eun Kim , Suresh Paudel , Se Jin Jeon , Kyu Suk Cho
IPC: C07D401/12 , C07D209/14 , C07D417/12 , C07D471/04 , C07C233/11 , C07D211/22 , C07D401/14
CPC classification number: C07D401/12 , C07D209/14 , C07D417/12 , C07D401/14 , C07C233/11 , C07D211/22 , C07D471/04
Abstract: Disclosed are a carboxamide derivative and a pharmaceutical composition comprising same as an active ingredient for use in preventing or treating mental illness. The derivative is superbly effective in a triple reuptake inhibitor of serotonin, norepinephrine, and dopamine, and thus can be effectively used in treating mental illness.
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公开(公告)号：US20230248740A1
公开(公告)日：2023-08-10
申请号：US17953867
申请日：2022-09-27
Applicant: DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION , NATIONAL CANCER CENTER , SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
Inventor： Hwan Geun Choi , Jong Bae Park , Eunhwa Ko , Jung Beom Son , Nam Doo Kim , Seung Hoon Lee , Do-Hyun Nam
IPC: A61K31/5513 , A61P35/04 , A61K31/415 , A61K31/4365 , A61K31/437 , A61K31/506 , A61K31/5377 , C07K16/22
CPC classification number: A61K31/5513 , A61K31/415 , A61K31/437 , A61K31/506 , A61K31/4365 , A61K31/5377 , A61P35/04 , C07K16/22
Abstract: Disclosed is a pharmaceutical composition for the prevention or treatment of brain cancer, containing a compound capable of penetrating the blood-brain barrier as an active ingredient, the pharmaceutical composition for the prevention or treatment of brain cancer is capable of efficiently penetrating the blood-brain barrier of the brain to thereby effectively inhibit LRRK2 protein expression, and is thus useful in the prevention or treatment of brain cancer.
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公开(公告)号：US20230374060A1
公开(公告)日：2023-11-23
申请号：US17914283
申请日：2021-03-24
Inventor： Soong-Hyun Kim , Eun Bi Ko , Minsoo Song , Ga Young Park , Eunhye Lee , Seri Bae , Jihee Kang , Yoojin Park , Youjeong Choi
IPC: C07J9/00
CPC classification number: C07J9/00
Abstract: The present invention relates to a novel method for preparing inotodiol, which is different from the existing method for preparing inotodiol and has a high yield of inotodiol, so it can be effectively used for preparing and mass-producing inotodiol.
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公开(公告)号：US20230212144A1
公开(公告)日：2023-07-06
申请号：US17927973
申请日：2021-05-25
Applicant: DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION , TRINEURO
Inventor： Minsoo Song , Ga Young Park , Eun Bi Ko , Jihee Kang , Chun Young Im , Seri Bae , Soong-Hyun Kim , Yoojin Park , Eunhye Lee , Yujeong Choi , Sang Bum Kim , Oh-Bin Kwon , Chan Young Shin , Kyoung Ja Kwon , Suresh Paudel , Se Jin Jeon , Kyu Suk Cho
IPC: C07D401/14 , C07D403/04 , C07D401/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D403/14 , C07D491/056
CPC classification number: C07D401/14 , C07D403/04 , C07D401/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D403/14 , C07D491/056
Abstract: The present invention relates to a 5-membered heteroaryl derivative containing an N, and a pharmaceutical composition for use in preventing or treating mental disorders, containing same as an active ingredient, wherein the derivative is excellent in the triple reuptake inhibitory effect of serotonin, norepinephrine, and dopamine, and thus can be useful in the treatment of mental disorders.
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10.发明公开公开(公告)号：US20230212121A1
公开(公告)日：2023-07-06
申请号：US17928032
申请日：2021-04-05
Applicant: DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION , TRINEURO
Inventor： Minsoo Song , Chun Young Im , Ga Young Park , Eun Bi Ko , Jihee Kang , Seri Bae , Soong-Hyun Kim , Yoojin Park , Eunhye Lee , Yujeong Choi , Jeongmin Joo , Sion Lee , Chan Young Shin , Kyoung Ja Kwon , Hee Jong Hwang , Suresh Paudel , Se Jin Jeon , Kyu Suk Cho
IPC: C07D211/14 , C07D401/12 , C07D215/36 , C07C307/02 , C07D401/04
CPC classification number: C07D211/14 , C07D401/12 , C07D215/36 , C07C307/02 , C07D401/04
Abstract: Disclosed are a sulfonamide derivative and a pharmaceutical composition comprising same as an active ingredient for use in preventing or treating mental illness. The derivative is superbly effective in a triple reuptake inhibitor of serotonin, norepinephrine, and dopamine, and thus can be effectively used in treating mental illness.
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