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    HYDROPHOBIC AND HYDROPHILIC INTERPENETRATING POLYMER NETWORKS DERIVED FROM HYDROPHOBIC POLYMERS AND METHODS OF PREPARING THE SAME
    3.
    发明申请
    HYDROPHOBIC AND HYDROPHILIC INTERPENETRATING POLYMER NETWORKS DERIVED FROM HYDROPHOBIC POLYMERS AND METHODS OF PREPARING THE SAME 审中-公开
    从疏水性聚合物衍生的疏水性和疏水性聚合物网络及其制备方法

    公开(公告)号：US20150284654A1

    公开(公告)日：2015-10-08

    申请号：US14536275

    申请日：2014-11-07

    申请人： David MYUNG ,  Michael J. JAASMA ,  Lampros KOURTIS ,  Daniel CHANG ,  Curtis W. FRANK

    发明人： David MYUNG ,  Michael J. JAASMA ,  Lampros KOURTIS ,  Daniel CHANG ,  Curtis W. FRANK

    IPC分类号： C10M107/44

    CPC分类号： C10M107/44 ,  A61K6/09 ,  C08G18/831 ,  C08G2270/00 ,  C08L33/02 ,  C08L33/12 ,  C08L75/04 ,  C08L75/06 ,  C08L75/16 ,  Y10T428/31551 ,  C08L2666/04 ,  C08L2666/20

    摘要： A composition of matter comprising a hydrophobic or hydrophilic (or both) interpenetrating polymer network containing a non-ionic/ionic polymer and a hydrophobic thermoset or thermoplastic polymer, articles made from such composition and methods of preparing such articles. The invention also includes a process for preparing a hydrophobic/hydrophilic IPN or semi-IPN from a hydrophobic thermoset or thermoplastic polymer including the steps of placing an non-ionizable/ionizable monomer solution in contact with a hydrophobic thermoset or thermoplastic polymer; diffusing the monomer solution into the hydrophobic thermoset or thermoplastic polymer; and polymerizing the monomers to form a penetrating polymer inside the hydrophobic thermoset or thermoplastic polymer, thereby forming the IPN or semi-IPN.

    摘要翻译： 包含含有非离子/离子聚合物和疏水性热固性或热塑性聚合物的疏水或亲水（或两者）互穿聚合物网络的物质组合物，由这样的组合物制成的制品以及制备这种制品的方法。 本发明还包括从疏水性热固性或热塑性聚合物制备疏水/亲水IPN或半IPN的方法，包括以下步骤：将不可离子化/可离子化的单体溶液与疏水性热固性或热塑性聚合物接触; 将单体溶液扩散到疏水性热固性聚合物或热塑性聚合物中; 并聚合单体以在疏水性热固性聚合物或热塑性聚合物内形成穿透性聚合物，从而形成IPN或半IPN。

    Hydrogel arthroplasty device
    4.
    发明授权
    Hydrogel arthroplasty device 有权
    水凝胶关节成形术装置

    公开(公告)号：US08679190B2

    公开(公告)日：2014-03-25

    申请号：US13418294

    申请日：2012-03-12

    申请人： David Myung ,  Lampros Kourtis ,  Laura Hartmann ,  Curtis W. Frank ,  Stuart B. Goodman ,  Dennis R. Carter

    发明人： David Myung ,  Lampros Kourtis ,  Laura Hartmann ,  Curtis W. Frank ,  Stuart B. Goodman ,  Dennis R. Carter

    IPC分类号： A61F2/30

    CPC分类号： A61F2/30756 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3603 ,  A61F2/3872 ,  A61F2/4202 ,  A61F2/4225 ,  A61F2/4241 ,  A61F2/4405 ,  A61F2002/30075 ,  A61F2002/30448 ,  A61F2002/30754 ,  A61F2002/3619 ,  A61F2210/0061 ,  A61F2220/005 ,  A61F2310/00293 ,  A61L27/18 ,  A61L27/34 ,  A61L27/3843 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/24

    摘要： An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.

    摘要翻译： 提供了一种具有互穿聚合物网络（IPN）水凝胶的关节成形术装置，其通过溶胀变形硬化并且适于通过符合骨几何形状在关节中保持就位。 应变硬化IPN水凝胶基于两个不同的网络：（1）通过其端基聚合化学交联的预先形成的亲水非离子遥爪大分子单体的非硅氧烷网络，和（2）非硅氧烷网络 的可离子化单体。 第二个网络在第一个网络的存在下被聚合和化学交联，并与第一个网络形成了物理交叉链路。 在IPN中，第二网络中的化学交联程度小于第一网络中的化学交联度。 使用盐水溶液（中性pH）来电离和膨胀第二网络。 第二个网络的肿胀受到第一个网络的限制，导致IPN内有效的物理交叉链路的增加。

    Surface modification of interpenetrating polymer networks
    5.
    发明授权
    Surface modification of interpenetrating polymer networks 失效
    互穿聚合物网络的表面改性

    公开(公告)号：US08329826B2

    公开(公告)日：2012-12-11

    申请号：US12590288

    申请日：2009-11-05

    申请人： Laura Hartmann ,  Stayce E. Beck ,  Jennifer R Cochran ,  Curtis W Frank

    发明人： Laura Hartmann ,  Stayce E. Beck ,  Jennifer R Cochran ,  Curtis W Frank

    IPC分类号： C08F8/14 ,  C08F8/32

    CPC分类号： C08J3/246 ,  C08G85/004 ,  C08J2300/14

    摘要： Surface modification methods for an interpenetrating polymer network (IPN) hydrogel to provide a basis for cell or tissue attachment are provided. The method involves the activation of functional groups on the surface of the IPN hydrogel. The activated functional groups are then reacted with amine-containing molecules or hydroxyl-containing molecules. The methods (i) can be performed in an aqueous environment and do not require the use of any organic solvent, (ii) do not require UV treatment, thereby avoiding denaturation of the IPN hydrogel or proteins, and/or (iii) can be performed as a one pot reaction.

    摘要翻译： 提供了互穿聚合物网络（IPN）水凝胶的表面改性方法，以提供细胞或组织附着的基础。 该方法涉及IPN水凝胶表面上的官能团的活化。 然后将活化的官能团与含胺分子或含羟基的分子反应。 方法（i）可以在水性环境中进行，不需要使用任何有机溶剂，（ii）不需要UV处理，从而避免IPN水凝胶或蛋白质变性，和/或（iii）可以 作为一锅反应进行。

    Hydrogel Arthroplasty Device
    6.
    发明申请
    Hydrogel Arthroplasty Device 有权
    水凝胶关节成形装置

    公开(公告)号：US20120232657A1

    公开(公告)日：2012-09-13

    申请号：US13418294

    申请日：2012-03-12

    申请人： David Myung ,  Lampros Kourtis ,  Laura Hartmann ,  Curtis W. Frank ,  Stuart B. Goodman ,  Dennis R. Carter

    发明人： David Myung ,  Lampros Kourtis ,  Laura Hartmann ,  Curtis W. Frank ,  Stuart B. Goodman ,  Dennis R. Carter

    IPC分类号： A61F2/02

    CPC分类号： A61F2/30756 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3603 ,  A61F2/3872 ,  A61F2/4202 ,  A61F2/4225 ,  A61F2/4241 ,  A61F2/4405 ,  A61F2002/30075 ,  A61F2002/30448 ,  A61F2002/30754 ,  A61F2002/3619 ,  A61F2210/0061 ,  A61F2220/005 ,  A61F2310/00293 ,  A61L27/18 ,  A61L27/34 ,  A61L27/3843 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/24

    摘要： An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.

    摘要翻译： 提供了一种具有互穿聚合物网络（IPN）水凝胶的关节成形术装置，其通过溶胀变形硬化并且适于通过符合骨几何形状在关节中保持就位。 应变硬化IPN水凝胶基于两个不同的网络：（1）通过其端基聚合化学交联的预先形成的亲水非离子遥爪大分子单体的非硅氧烷网络，和（2）非硅氧烷网络 的可离子化单体。 第二个网络在第一个网络的存在下被聚合和化学交联，并与第一个网络形成了物理交叉链路。 在IPN中，第二网络中的化学交联程度小于第一网络中的化学交联度。 使用盐水溶液（中性pH）来电离和膨胀第二网络。 第二个网络的肿胀受到第一个网络的限制，导致IPN内有效的物理交叉链路的增加。

    Three-dimensionally shaped interpenetrating network hydrogels
    10.
    发明申请
    Three-dimensionally shaped interpenetrating network hydrogels 审中-公开
    三维形状的互穿网络水凝胶

    公开(公告)号：US20100174021A1

    公开(公告)日：2010-07-08

    申请号：US12653293

    申请日：2009-12-11

    申请人： Philip Huie, JR. ,  Dale Jon Waters ,  Curtis W. Frank ,  Christopher N. Ta ,  Ariane C. Tom

    发明人： Philip Huie, JR. ,  Dale Jon Waters ,  Curtis W. Frank ,  Christopher N. Ta ,  Ariane C. Tom

    IPC分类号： C08K5/06 ,  C08J3/00

    CPC分类号： A61L27/52

    摘要： Three-dimensionally (3-D) shaped interpenetrating double network (IPN) hydrogel based on a first network and a second network are provided. The 3-D shape is characterized by a non-uniform distribution of the second network (e.g. carboxylic acid groups) when in hydrated state. The 3-D shape can further be characterized by changes in the radius of curvature of the shape. The 3-D IPN hydrogel is created by applying a non-uniform illumination pattern to polymerize the second network of monomers within a layer of a first network. In hydrated state, the second network causes a swelling force that is resisted by the first network. The non-uniformal distribution of the second network with the first network is responsible for the 3-D of the resulting IPN. The invention can find use in ophthalmic applications as well as non-ophthalmic applications.

    摘要翻译： 提供了基于第一网络和第二网络的三维（3-D）形状互穿双网络（IPN）水凝胶。 当处于水合状态时，3-D形状的特征在于第二网络（例如羧酸基团）的不均匀分布。 3-D形状可以进一步由形状的曲率半径的变化来表征。 通过施加不均匀照明图案以在第一网络的层内聚合单体的第二网络来产生3-D IPN水凝胶。 在水合状态下，第二网络引起第一网络抵抗的膨胀力。 第二个网络与第一个网络的不均匀分布负责所产生的IPN的3-D。 本发明可用于眼科应用以及非眼科应用。