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1.发明申请Prosthetic Intervertebral Discs Having Substantially Rigid End Plates and Fibers Between Those End Plates 有权在这些端板之间具有基本刚性端板和纤维的假体椎间盘公开(公告)号：US20080103599A1
公开(公告)日：2008-05-01
申请号：US11968183
申请日：2008-01-01
申请人： Daniel Kim , Thomas Afzal , Michael Reo , Uriel Chee , In Cho , Kunwoo Lee , Curtis Frank , Sung Kyu Ha
发明人： Daniel Kim , Thomas Afzal , Michael Reo , Uriel Chee , In Cho , Kunwoo Lee , Curtis Frank , Sung Kyu Ha
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the sagittal plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.
摘要翻译： 描述了假体椎间盘及其使用方法。 主体假体盘包括由可压缩的芯构件分开的上端板和下端板。 本文所述的假体盘包括一件式，两件式，三件式和四件式结构。 主体假体椎板在垂直方向上呈现刚度，扭转刚度，矢状平面中的弯曲刚度和前平面中的弯曲刚度，其中可以通过调节椎间盘的部件来独立地控制这些特征的程度。 所描述的假体盘的几个实施例的端板和芯构件之间的界面机构能够实现非常容易的用于植入的外科手术。
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2.发明申请Prosthetic intervertebral discs having stiff end plates and a compressible polymeric core 有权具有刚性端板和可压缩聚合物芯的假体椎间盘公开(公告)号：US20070168034A1
公开(公告)日：2007-07-19
申请号：US11528100
申请日：2006-09-27
申请人： Daniel Kim , Kunwoo Lee , Curtis Frank , Sung Ha
发明人： Daniel Kim , Kunwoo Lee , Curtis Frank , Sung Ha
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： A prosthetic intervertebral disc and methods for using the same are provided. The subject prosthetic discs are characterized by including top and bottom endplates separated by a fibrous compressible element that includes an annular region and a nuclear region. The two plates are held together at least one fiber wound around at least one region of the top endplate and at least one region of the bottom endplate. The subject discs may be employed with separate vertebral body fixation elements, or they may include integrated vertebral body fixation elements. Also provided are kits and systems that include the subject prosthetic discs.
摘要翻译： 提供假体椎间盘及其使用方法。 主体假体盘的特征在于包括由包括环形区域和核区域的纤维状可压缩元件分开的顶端和底端板。 两个板保持在至少一根纤维上，该纤维缠绕在顶端板的至少一个区域和底端板的至少一个区域中。 受试盘可以与独立的椎体固定元件一起使用，或者它们可以包括集成的椎体固定元件。 还提供了包括主题假体盘的套件和系统。
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公开(公告)号：US20060287721A1
公开(公告)日：2006-12-21
申请号：US11409218
申请日：2006-04-20
申请人： David Myung , Christopher Ta , Nabeel Farooqui , Curtis Frank , Won-Gun Koh , Jungmin Ko , Jaan Noolandi , Michael Carrasco
发明人： David Myung , Christopher Ta , Nabeel Farooqui , Curtis Frank , Won-Gun Koh , Jungmin Ko , Jaan Noolandi , Michael Carrasco
IPC分类号： A61F2/14
摘要： The present invention provides an artificial corneal implant having an optically clear central core and a porous, hydrophilic, biocompatible skirt peripheral to the central core. In one embodiment, the central core is made of an interpenetrating double network hydrogel and the skirt is made of poly(2-hydroxyethyl acrylate) (PHEA). In another embodiment, both the central core and the skirt are made of interpenetrating double network hydrogels. The artificial corneal implant may also have an interdiffusion zone in which the skirt component is interpenetrated with the core component, or vice versa. In a preferred embodiment, biomolecules are linked to the skirt, central core or both. These biomolecules may be any type of biomolecule, but are preferably biomolecules that support epithelial and/or fibroblast cell survival and growth. Preferably, the biomolecules are linked in a spatially selective manner. The present invention also provides a method of making an artificial corneal implant using photolithography.
摘要翻译： 本发明提供了一种人造角膜植入物，其具有光学透明的中心纤芯和围绕中心纤芯的多孔，亲水的，生物相容的裙部。 在一个实施方案中，中心芯由互穿双网络水凝胶制成，裙部由聚（丙烯酸2-羟乙酯）（PHEA）制成。 在另一个实施例中，中心芯和裙部均由互穿双网络水凝胶制成。 人造角膜植入物也可以具有相互扩散区域，其中裙部组件与芯部件互穿，反之亦然。 在优选的实施方案中，生物分子连接到裙部，中心芯或两者。 这些生物分子可以是任何类型的生物分子，但优选支持上皮和/或成纤维细胞存活和生长的生物分子。 优选地，生物分子以空间选择性方式连接。 本发明还提供了使用光刻法制造人造角膜植入物的方法。
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公开(公告)号：US1003586A
公开(公告)日：1911-09-19
申请号：US1911603433
申请日：1911-01-19
申请人： CURTIS FRANK C
发明人： CURTIS FRANK C
CPC分类号： H01H85/0454
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公开(公告)号：US831563A
公开(公告)日：1906-09-25
申请号：US1902299745
申请日：1902-11-22
申请人： MOSHER GEORGE A , CURTIS FRANK C
发明人： MOSHER GEORGE A , CURTIS FRANK C
CPC分类号： F03B15/00 , F01D25/12 , Y02E10/226
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6.发明申请Prosthetic intervertebral discs having substantially rigid end plates and fibers between those end plates 审中-公开假体椎间盘具有基本上刚性的端板和在这些端板之间的纤维公开(公告)号：US20070168033A1
公开(公告)日：2007-07-19
申请号：US11527804
申请日：2006-09-26
申请人： Daniel Kim , Thomas Afzal , Michael Reo , Uriel Chee , In Cho , Kunwoo Lee , Curtis Frank , Sung Kyu Ha
发明人： Daniel Kim , Thomas Afzal , Michael Reo , Uriel Chee , In Cho , Kunwoo Lee , Curtis Frank , Sung Kyu Ha
IPC分类号： A61F2/44
CPC分类号： A61F2/4425 , A61B17/86 , A61F2/30742 , A61F2/30767 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30133 , A61F2002/30383 , A61F2002/30462 , A61F2002/305 , A61F2002/3052 , A61F2002/30523 , A61F2002/30563 , A61F2002/30566 , A61F2002/30578 , A61F2002/30596 , A61F2002/30604 , A61F2002/30733 , A61F2002/30841 , A61F2002/30884 , A61F2002/30904 , A61F2002/448 , A61F2002/4495 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0075 , A61F2230/0015 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00161 , A61F2310/00179 , A61L2430/38
摘要： Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the saggital plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.
摘要翻译： 描述了假体椎间盘及其使用方法。 主体假体盘包括由可压缩的芯构件分开的上端板和下端板。 本文所述的假体盘包括一件式，两件式，三件式和四件式结构。 主体假体椎板在垂直方向上呈现刚度，扭转刚度，屈曲平面中的弯曲刚度和前平面中的弯曲刚度，其中可以通过调节椎间盘的部件来独立地控制这些特征的程度。 所描述的假体盘的几个实施例的端板和芯构件之间的界面机构能够实现非常容易的用于植入的外科手术。
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7.发明申请公开(公告)号：US20060134672A1
公开(公告)日：2006-06-22
申请号：US11289897
申请日：2005-11-30
申请人： Ying Chang , Curtis Frank , Glenn McGall
发明人： Ying Chang , Curtis Frank , Glenn McGall
CPC分类号： C07H21/00 , C07B2200/11 , C08F4/02 , C08F289/00 , C08F290/06 , C08L51/08 , C08L51/10 , C40B40/00 , G01N33/544
摘要： Polymeric brush substrates and methods for their preparation are provided. Methods are also provided for preparing macromolecular arrays on such polymeric brush substrates. Using polymeric brush substrates allows control over functional site density as well as wettability and porosity of the substrate. These polymeric brushes are useful in solid-phase synthesis of arrays of peptides, polynucleotides or small organic molecules.
摘要翻译： 提供聚合物刷底物及其制备方法。 还提供了用于在这种聚合物刷基底上制备高分子阵列的方法。 使用聚合物刷基质可以控制基质的功能位点密度以及润湿性和孔隙率。 这些聚合物刷可用于肽，多核苷酸或小有机分子阵列的固相合成。
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公开(公告)号：US2452440A
公开(公告)日：1948-10-26
申请号：US76110947
申请日：1947-07-15
申请人： DE CURTIS FRANK
发明人： DE CURTIS FRANK
CPC分类号： A43D3/1408 , A43D3/08
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公开(公告)号：US2279304A
公开(公告)日：1942-04-14
申请号：US35920640
申请日：1940-10-01
申请人： DE CURTIS FRANK , DE VITO FELIX
发明人： DE CURTIS FRANK , DE VITO FELIX
CPC分类号： A43D95/00 , A43D3/1408 , A43D3/1433
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公开(公告)号：US1369521A
公开(公告)日：1921-02-22
申请号：US41048720
申请日：1920-09-15
申请人： DE CURTIS FRANK
发明人： DE CURTIS FRANK
IPC分类号： E05B37/00
CPC分类号： E05B37/00 , Y10T70/7169
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