公开(公告)号：US20180251489A1

公开(公告)日：2018-09-06

申请号：US15755951

申请日：2016-08-26

Applicant: Cornell University Cornell Center for Technology Enterprise & Commercialization (CCTEC) ,  Dana-Farber Cancer Institute, Inc. ,  Children's Medical Center Corporation

Inventor： Nathanael S. Gray ,  David A Scott ,  John Hatcher ,  Spandan Chennamadhavuni ,  Ari M. Melnick ,  Lorena Fontan Gabas ,  Hao Wu ,  Qi Qiao ,  Guangyan Du

IPC: C07K5/11 ,  A61K38/07

Abstract: Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT, lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).