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公开(公告)号：US5389664A
公开(公告)日：1995-02-14
申请号：US223377
申请日：1994-04-05
IPC分类号： A61K31/415 , A61K31/44 , A61K38/27 , A61K31/445 , A61K31/47 , A61K37/00
CPC分类号： A61K31/44 , A61K31/415 , A61K38/27 , Y10S514/806 , Y10S514/866
摘要： Alleviation of stomach ulcers in swine which are being administered exogenous somatotropin, by administering to the swine a benzimidazole compound selected from heterocyclylalkyl(sulfinyl or thio)benzimidazoles and [benzimidazolyl(sulfinyl or thio)alkyl]anilines.
摘要翻译： 通过对猪施用选自杂环基烷基（亚磺酰基或硫代）苯并咪唑和[苯并咪唑基（亚硫酰基或硫代）烷基]苯胺的苯并咪唑化合物，减轻正在施用外源性生长激素的猪的胃溃疡。
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公开(公告)号：US5308348A
公开(公告)日：1994-05-03
申请号：US58151
申请日：1993-05-05
CPC分类号： A61M5/14526 , A61K9/0004 , A61M2005/14513 , A61M2206/10
摘要： Delivery devices which include a beneficial agent and an activating mechanism in separate compartments separated by a moveable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a band of resilient material which is placed over the orifice. The resilient material is sufficiently tight to substantially seal the orifice when the pressure within the device is below a threshold level while at the same time being capable of being stretched when the internal pressure exceeds the threshold.
摘要翻译： 包括有益剂和活化机构的输送装置被设计成以可动的方式通过孔传送有益剂。 脉动输送通过放置在孔口上方的弹性材料带来实现。 当装置内的压力低于阈值水平时，同时能够在内部压力超过阈值时拉伸，弹性材料足够紧密以基本上密封孔口。
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3.发明授权Methods and compositions for increasing growth rate and feed efficiency of animals 失效增加动物生长速度和饲料效率的方法和组合物
公开(公告)号：US3939275A
公开(公告)日：1976-02-17
申请号：US466425
申请日：1974-05-02
IPC分类号： A23K1/16 , A61K31/245
CPC分类号： A23K20/132 , A23K20/111
摘要： Methods and compositions utilizing certain local anesthetic derivatives which increase growth rate and feed efficiency of animals, particularly ruminants. The preferred compounds to be used as active ingredients are local anesthetics, such as, for example, mepivacaine hydrochloride, bupivacaine hydrochloride, tetracaine hydrochloride, and oxethazainechloro hydrochloride.
摘要翻译： 使用某些局部麻醉衍生物的方法和组合物，其增加动物，特别是反刍动物的生长速率和饲料效率。 用作活性成分的优选化合物是局部麻醉剂，例如盐酸甲哌卡因，盐酸布比卡因，盐酸丁卡因和盐酸羟乙基氯苯甲酸。
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4.发明申请公开(公告)号：US20100093678A1
公开(公告)日：2010-04-15
申请号：US12587393
申请日：2009-10-06
CPC分类号： A61K31/59 , A61K31/12 , A61K31/352 , A61K31/57 , A61K31/593 , A61K45/06 , A61K2300/00
摘要： The present invention relates to naturally occurring compositions comprising vitamin D3 or related analog and methods for treating obesity and/or osteoporosis and reducing body fat or enhancing a bone graft in patients in need thereof.
摘要翻译： 本发明涉及包含维生素D3或相关类似物的天然存在的组合物以及用于治疗有需要的患者的肥胖和/或骨质疏松症以及减少体内脂肪或增强骨移植物的方法。
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公开(公告)号：US20090075957A1
公开(公告)日：2009-03-19
申请号：US12209681
申请日：2008-09-12
IPC分类号： A61K31/12 , A61P3/00 , A61P19/00 , A61K31/57 , A61K31/352
CPC分类号： A61K31/12 , A61K31/352 , A61K31/57 , Y10S514/909 , A61K2300/00
摘要： The present invention provides compositions comprising an effective amount of xanthohumol and honokiol. The present invention comprises compositions comprising an effective amount of xanthohumol and genistein. The present invention comprises compositions comprising an effective amount of xanthohumol and guggulsterone. The compositions of the present invention may be effective to decrease mature adipocytes viability, induce apoptosis of mature adipocytes, increase lipolysis in mature adipocytes, and/or reduce adipogenesis during the maturation of pre-adipocytes. The present invention further provides methods of treating obesity, diabetes, osteoporosis or bone disorders in a subject, which comprise administering to the subject compositions comprising an effective amount of xanthohumol and honokiol, guggulsterone, or genistein.
摘要翻译： 本发明提供了包含有效量的黄腐酚和和厚朴酚的组合物。 本发明包括含有有效量的黄腐酚和染料木素的组合物。 本发明包括包含有效量的黄腐酚和古格斯酮的组合物。 本发明的组合物可有效降低成熟脂肪细胞存活力，诱导成熟脂肪细胞的凋亡，增加成熟脂肪细胞中的脂肪分解，和/或在脂肪细胞成熟期间减少脂肪形成。 本发明进一步提供了治疗受试者中的肥胖症，糖尿病，骨质疏松症或骨骼疾病的方法，其包括给予包含有效量的黄腐酚和和厚朴酚，鬼臼酮或染料木素的对象组合物。
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6.发明授权8-Alkyl and alkenyl-10-hydroxy-5H[1]benzopyranopyridine derivatives having polyphagic activity 失效8-烷基和链烯基-10-羟基-5H- {具有多肽活性的{8 1 {9-苯并吡喃并吡啶衍生物
公开(公告)号：US3962448A
公开(公告)日：1976-06-08
申请号：US570130
申请日：1975-04-21
申请人： Clifton A. Baile , Paul E. Bender , Bernard Loev
发明人： Clifton A. Baile , Paul E. Bender , Bernard Loev
IPC分类号： C07D491/04 , A61K31/44
CPC分类号： C07D491/04
摘要： 8-Alkyl and alkenyl-10-hydroxy-5H[1]benzopyranopyridines are prepared by dehydrogenation of the corresponding N-benzyl or N-hydrogen-8-alkyl or alkenyl-1,2,3,4-tetrahydro-5H[1]benzopyranopyridines in a high boiling solvent in the presence of a noble metal dehydrogenation catalyst. Alkyl derivatives of 5-11 carbon atoms are particularly useful. Also the O-acetyl derivatives are very useful. The compounds are central nervous system depressants and animal polyphagic agents.
摘要翻译： 8-烷基和链烯基-10-羟基-5H [1]苯并吡喃并吡啶通过相应的N-苄基或N-氢-8-烷基或链烯基-1,2,3,4-四氢-5H- [1] 苯并吡喃并吡啶在高沸点溶剂中，在贵金属脱氢催化剂存在下进行。 5-11个碳原子的烷基衍生物是特别有用的。 O-乙酰基衍生物也是非常有用的。 这些化合物是中枢神经系统抑制剂和动物多药剂。
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公开(公告)号：US08101213B2
公开(公告)日：2012-01-24
申请号：US12209681
申请日：2008-09-12
IPC分类号： A61K36/00 , A61K31/56 , A61K31/35 , A61K31/045
CPC分类号： A61K31/12 , A61K31/352 , A61K31/57 , Y10S514/909 , A61K2300/00
摘要： The present invention provides compositions comprising an effective amount of xanthohumol and honokiol. The present invention comprises compositions comprising an effective amount of xanthohumol and genistein. The present invention comprises compositions comprising an effective amount of xanthohumol and guggulsterone. The compositions of the present invention may be effective to decrease mature adipocytes viability, induce apoptosis of mature adipocytes, increase lipolysis in mature adipocytes, and/or reduce adipogenesis during the maturation of pre-adipocytes. The present invention further provides methods of treating obesity, diabetes, osteoporosis or bone disorders in a subject, which comprise administering to the subject compositions comprising an effective amount of xanthohumol and honokiol, guggulsterone, or genistein.
摘要翻译： 本发明提供了包含有效量的黄腐酚和和厚朴酚的组合物。 本发明包括含有有效量的黄腐酚和染料木素的组合物。 本发明包括包含有效量的黄腐酚和古格斯酮的组合物。 本发明的组合物可有效降低成熟脂肪细胞存活力，诱导成熟脂肪细胞的凋亡，增加成熟脂肪细胞中的脂肪分解，和/或在脂肪细胞成熟期间减少脂肪形成。 本发明进一步提供了治疗受试者中的肥胖症，糖尿病，骨质疏松症或骨骼疾病的方法，其包括给予包含有效量的黄腐酚和和厚朴酚，鬼臼酮或染料木素的对象组合物。
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公开(公告)号：US5456679A
公开(公告)日：1995-10-10
申请号：US352268
申请日：1994-12-07
CPC分类号： A61K9/0004 , A61M5/14526 , A61M2005/14513 , A61M2206/10
摘要： Delivery devices which include a beneficial agent and an activating mechanism in separate compartments separated by a moveable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a band of resilient material which is placed over the orifice. The resilient material is sufficiently tight to substantially seal the orifice when the pressure within the device is below a threshold level while at the same time being capable of being stretched when the internal pressure exceeds the threshold.
摘要翻译： 包括有益剂和活化机构的输送装置被设计成以可动的方式通过孔传送有益剂。 脉动输送通过放置在孔口上方的弹性材料带来实现。 当装置内的压力低于阈值水平时，同时能够在内部压力超过阈值时拉伸，弹性材料足够紧密以基本上密封孔口。
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公开(公告)号：US3978221A
公开(公告)日：1976-08-31
申请号：US555337
申请日：1975-03-04
IPC分类号： A23K1/16 , A61K31/445 , A61K31/40
CPC分类号： A23K20/132
摘要： Compositions and methods for inducing polyphagia or eating in meat producing animals comprise administering orally or preferably by injection an effective but nontoxic subpharmacodynamic quantity of a benzhydryl ether active ingredient. Preferred active ingredients are tropine benzohydryl ether, 3-quinuclidinyl benzohydryl ether or their nontoxic acid addition salts.
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10.发明授权Methods and compositions for improving the feed intake of meat producing animals 失效用于改善肉类生产动物饲料摄入量的方法和组合物
公开(公告)号：US3932637A
公开(公告)日：1976-01-13
申请号：US490813
申请日：1974-07-22
CPC分类号： A61K31/55 , A23K20/116 , A23K20/137
摘要： Compositions and methods for inducing polyphagia in immature meat producing animals comprise administering orally or by injection an effective but nontoxic subpharmacodynamic quantity of a 1,4-benzodiazepinone active ingredient whose structure is characterized by an 1-alkyl-sulfonylalkyl moiety. Preferred active ingredients are 1-(ethylsulfonylethyl)-5-(o-halophenyl)-7-halo-1,3-dihydro-2H-1,4-benzodiazepin-2-ones.
摘要翻译： 在未成熟肉生产动物中诱导多食的组合物和方法包括口服或注射有效但无毒的亚药效动力学量的1,4-苯并二氮杂酮活性成分，其结构由1-烷基 - 磺酰基烷基部分表征。 优选的活性成分是1-（乙基磺酰基乙基）-5-（邻卤苯基）-7-卤代-1,3-二氢-2H-1,4-苯并二氮杂-2-酮。
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