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124 条记录 (耗时 0.028 秒)

    LONG-TERM TREATMENT OF SYMPTOMATIC HEART FAILURE
    1.
    发明申请
    LONG-TERM TREATMENT OF SYMPTOMATIC HEART FAILURE 有权
    长期治疗症状性心脏衰竭

    公开(公告)号：US20110178111A1

    公开(公告)日：2011-07-21

    申请号：US13057492

    申请日：2009-07-23

    申请人： Claudio Cavazza ,  Maria Giovanna Caccia

    发明人： Claudio Cavazza ,  Maria Giovanna Caccia

    IPC分类号： A61K31/202 ,  C07C57/03 ,  A61K31/232 ,  A61K31/366 ,  A61K31/404 ,  A61K31/22 ,  A61K31/40 ,  A61K31/4418 ,  A61K31/505 ,  A61P9/06 ,  A61P9/00 ,  A61P9/04

    CPC分类号： A61K31/23

    摘要： The main object here is the use of omega-3 polyunsaturated fatty acids (as ethyl esters, hereinafter called “n-3 PUFA”) as a medicament, either alone or in combination with other therapeutic agents, for reducing mortality for a cardiovascular cause, in particular arrhythmia or for reducing hospitalization for any cause, in particular a cardiovascular cause and for the daily administration to patients with symptomatic heart failure (HF) for more than 3.5 years.

    摘要翻译： 这里的主要目的是使用ω-3多不饱和脂肪酸（作为乙酯，以下称为“n-3 PUFA”）作为药物，单独使用或与其它治疗剂组合用于降低心血管原因的死亡率， 特别是心律失常或用于减少任何原因的住院治疗，特别是心血管原因和用于有症状心力衰竭（HF）患者的日常给药超过3.5年。

    Medicament for preventing and/or treating peripheral neuropathies
    2.
    发明申请
    Medicament for preventing and/or treating peripheral neuropathies 审中-公开
    用于预防和/或治疗周围神经病的药物

    公开(公告)号：US20060258744A1

    公开(公告)日：2006-11-16

    申请号：US11407351

    申请日：2006-04-20

    申请人： Claudio Cavazza ,  Claudio Pisano ,  Loredana Vesci ,  Franco Mandelli

    发明人： Claudio Cavazza ,  Claudio Pisano ,  Loredana Vesci ,  Franco Mandelli

    IPC分类号： A61K31/22 ,  A61K31/7072 ,  A61K31/4745 ,  A61K31/454 ,  A61K31/427 ,  A61K31/337 ,  A61K31/282

    CPC分类号： A61K45/06 ,  A61K31/205 ,  A61K31/221 ,  A61K31/28 ,  A61K31/335 ,  A61K31/475 ,  A61K31/555 ,  A61K33/24 ,  A61K38/14 ,  A61K2300/00

    摘要： This invention disclosed the use of acetyl L-carnitine or of a pharmaceutically acceptable salt thereof for the preparation of a medicament for preventing and/or treating peripheral neuropathies induced by the administration of a peripheral neuropathy—inducing anticancer agent. In particular said anticancer agent is selected from the group consisting of the family of platin compounds, taxanes, epothilone class and vinca alkaloids, farnesyl transferase inhibitors, thalidomide, 5-fluorouracil, cryptophycin analogues, proteasome inhibitors. Said medicament can be administered in a co-ordinated manner to a subject suffering from said peripheral neuropathies, or expected to suffer from said peripheral neuropathies. Beneficial effects on the patient's quality of life are achieved and an improvement of therapeutic index of the anticancer agent is obtained.

    摘要翻译： 本发明公开了乙酰基左旋肉碱或其药学上可接受的盐在制备用于预防和/或治疗通过施用周围神经病诱导抗癌剂诱发的周围神经病变的药物中的应用。 特别地，所述抗癌剂选自铂族化合物，紫杉烷类，埃坡霉素类和长春花生物碱家族，法呢基转移酶抑制剂，沙利度胺，5-氟尿嘧啶，隐球菌素类似物，蛋白酶体抑制剂。 所述药物可以以协调的方式施用于患有所述周围神经病的受试者，或预期患有所述周围神经病。 实现对患者生活质量的有益影响，获得抗癌剂治疗指数的改善。

    Composition for the prevention and/or treatment of disorders due to abnormal lipid metabolism, comprising propionyl l-carnitine and chitosan
    3.
    发明授权
    Composition for the prevention and/or treatment of disorders due to abnormal lipid metabolism, comprising propionyl l-carnitine and chitosan 失效
    用于预防和/或治疗由于脂质代谢异常引起的疾病的组合物，包括丙酸左旋肉碱和壳聚糖

    公开(公告)号：US06780851B1

    公开(公告)日：2004-08-24

    申请号：US10130481

    申请日：2002-05-20

    申请人： Claudio Cavazza

    发明人： Claudio Cavazza

    IPC分类号： A61K31722

    CPC分类号： A61K31/205 ,  A61K31/722 ,  Y10S514/909 ,  A61K2300/00

    摘要： A composition is disclosed suitable for the prevention and/or treatment of disorders due to abnormal lipid metabolism, such as hypercholesterolaemia, atherosclerosis, hyperlipidaemia and obesity, and which can therefore take the form of a dietary supplement or of an actual medicine, comprising as characterising active ingredients: (a) propionyl L-carnitine or a pharmacologically acceptable salt thereof, and (b) chitosan or its derivatives and congeners.

    摘要翻译： 公开的组合物适用于预防和/或治疗由脂质代谢异常引起的疾病，如高胆固醇血症，动脉粥样硬化，高脂血症和肥胖症，因此可以采取饮食补充剂或实际药物的形式，其特征在于 活性成分：（a）丙酰基左旋肉碱或其药理学上可接受的盐，和（b）壳聚糖或其衍生物和同系物。

    Carnitine and inositol phosphate-containing composition useful as dietary supplement or drug
    5.
    发明授权
    Carnitine and inositol phosphate-containing composition useful as dietary supplement or drug 有权
    肉碱和含肌醇磷酸盐的组合物可用作膳食补充剂或药物

    公开(公告)号：US06565876B1

    公开(公告)日：2003-05-20

    申请号：US09720099

    申请日：2000-12-21

    申请人： Claudio Cavazza

    发明人： Claudio Cavazza

    IPC分类号： A61K4700

    CPC分类号： A61K31/7024 ,  A61K31/66 ,  A61K31/70 ,  A61K31/205 ,  A61K2300/00

    摘要： A composition is disclosed suitable for the prevention and/or treatment of cardiovascular and neurocerebral disorders, tissue anoxic forms, muscular energy deficits, inflammatory-type abnormalities, alterations of blood coagulation such as thrombosis, and tissue proliferation forms, that may take the form of a dietary supplement, dietetic support or of an actual medicine, which comprises as characterizing active ingredients: (a) propionyl L-carnitine or a pharmacologically acceptable salt thereof; and (b) an inositol phosphate, particularly the inositol hexaphosphate (IP6).

    摘要翻译： 公开的组合物适合于预防和/或治疗心血管和神经性脑疾病，组织缺氧形式，肌肉能量缺陷，炎性类型异常，凝血变化如血栓形成和组织增生形式，其可以采取 膳食补充剂，饮食支持或实际药物，其包括作为活性成分的特征：（a）L-肉碱丙酰胺或其药理学上可接受的盐; 和（b）磷酸肌醇，特别是肌醇六磷酸（IP6）。

    Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
    8.
    发明授权
    Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans 失效
    用于增加人类精子浓度和/或运动性的组合物和方法

    公开(公告)号：US6090848A

    公开(公告)日：2000-07-18

    申请号：US122897

    申请日：1998-07-28

    申请人： Claudio Cavazza

    发明人： Claudio Cavazza

    IPC分类号： A61K31/205 ,  A61K31/221 ,  A61P15/08 ,  A61K31/225

    CPC分类号： A61K31/205

    摘要： A method is disclosed for treating idiopathic asthenozoospermia and improving sperm quality which comprises orally or parenterally administering to a subject in need thereof a combination preparation comprising either an admixture of or separately packaged L-carnitine and acetyl L-carnitine, or a pharmacologically acceptable salt thereof, in molar ratios ranging from about 4.0:1 to 1:1.5.

    摘要翻译： 公开了一种用于治疗特发性无精症和提高精子质量的方法，其包括口服或肠胃外给予需要的受试者的组合制剂，其包含L-肉碱的混合物或单独包装的L-肉碱和乙酰左旋肉碱，或其药理学上可接受的盐 ，摩尔比范围为约4.0:1至1:1.5。