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公开(公告)号：US12130286B2
公开(公告)日：2024-10-29
申请号：US17806109
申请日：2022-06-09
申请人： Shahrzad Forouzanfar , Iman Khakpour , Nezih Pala , Chunlei Wang
发明人： Shahrzad Forouzanfar , Iman Khakpour , Nezih Pala , Chunlei Wang
IPC分类号： G01N33/543 , G01N27/30 , G01N27/327 , G01N33/574
CPC分类号： G01N33/5438 , G01N27/308 , G01N27/3276 , G01N33/57484 , G01N2333/49
摘要： Biosensors capable of detecting certain biomarkers (e.g., platelet-derived growth factor-BB (PDGF-BB)), as well as methods of fabricating the same and methods of using the same, are provided. The biosensors can be disposable and/or label-free. Electrochemical bipolar exfoliation can be used to exfoliate, reduce, and deposit (in a single step) graphene nanosheets on a desired substrate (e.g., an electrode). Affinity aptamers can be immobilized on the graphene nanosheets disposed on the substrate.
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公开(公告)号：US11605507B1
公开(公告)日：2023-03-14
申请号：US17839984
申请日：2022-06-14
摘要： Microsupercapacitors (MSCs), as well as methods of fabricating the same and methods of using the same, are provided. An MSC can include interdigitated microelectrodes having reduced graphene oxide (rGO) (e.g., vertically aligned nanosheets thereof) disposed on upper surfaces of the microelectrodes. The MSC can be fabricated by preparing a micro-current collector (MCC) comprising the interdigitated microelectrodes using photolithography and then performing a bipolar electrochemistry process on the MCC to deposit rGO on the upper surfaces of the interdigitated microelectrodes (e.g., in a single-step in situ exfoliation, reduction, and deposition).
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公开(公告)号：US20220395884A1
公开(公告)日：2022-12-15
申请号：US17347801
申请日：2021-06-15
申请人： Dajun Zhou , Chunlei Wang , Robert D Miller , Kaiping Li , Yongjun Zhou , Richard J Siemen
发明人： Dajun Zhou , Chunlei Wang , Robert D Miller , Kaiping Li , Yongjun Zhou , Richard J Siemen
摘要： A stamping apparatus that includes an upper die, a blank-holding binder, and fixed lower die. The fixed lower die features a drawing punch and the upper die features a corresponding cavity. The fixed lower die includes a stake bead and a corresponding depression is present on the upper die. The blank-holding binder includes a draw bead and a corresponding depression is present on the upper die. In the stamping process, the draw bead engages a blank in a first stage, causing the blank to begin to stretch into the shape of the drawing punch with a greater tightened partially finished panel shape. In a second stage, the draw bead disengages the blank as the blank is drawn towards the drawing punch. In a final stage, the stake bead engages the blank to tighten the blank around the drawing punch into a final shape.
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公开(公告)号：US11130283B2
公开(公告)日：2021-09-28
申请号：US17163823
申请日：2021-02-01
申请人： Omena Okpowe , Nezih Pala , Chunlei Wang
发明人： Omena Okpowe , Nezih Pala , Chunlei Wang
IPC分类号： B29C64/165 , B29C64/314 , B29C64/35 , B29C64/188 , B33Y40/10 , B33Y40/20 , B33Y10/00 , B33Y80/00 , C03C3/095 , C03C3/089 , G01T1/20 , C03B19/06
摘要： Doped glass scintillators and methods of fabricating the same are provided. Doped glass scintillators can be fabricated by a stereolithography process, and doping can be carried out before the green body composite formation so that homogeneity of the dopant is improved. The structures retain an amorphous structure through the fabrication process, and the vacuum sintering process assists with keeping the dopants in their luminescence-producing oxidation state.
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公开(公告)号：US20210229349A1
公开(公告)日：2021-07-29
申请号：US17163823
申请日：2021-02-01
申请人： OMENA OKPOWE , NEZIH PALA , CHUNLEI WANG
发明人： OMENA OKPOWE , NEZIH PALA , CHUNLEI WANG
IPC分类号： B29C64/165 , B29C64/314 , B29C64/35 , B29C64/188
摘要： Doped glass scintillators and methods of fabricating the same are provided. Doped glass scintillators can be fabricated by a stereolithography process, and doping can be carried out before the green body composite formation so that homogeneity of the dopant is improved. The structures retain an amorphous structure through the fabrication process, and the vacuum sintering process assists with keeping the dopants in their luminescence-producing oxidation state.
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公开(公告)号：US20060068107A1
公开(公告)日：2006-03-30
申请号：US11090918
申请日：2005-03-25
申请人： Marc Madou , Chunlei Wang , Lili Taherabadi , Benjamin Park , Rabih Zaouk
发明人： Marc Madou , Chunlei Wang , Lili Taherabadi , Benjamin Park , Rabih Zaouk
IPC分类号： C23C16/00
CPC分类号： B81C1/00547 , B81C1/00111 , B82Y30/00 , C23C16/04 , C23C16/26 , Y10S977/844 , Y10S977/947
摘要： C-MEMS architecture having carbon structures with high surface areas due to high aspect ratios and nanoscale surface enhancements, and improved systems and methods for producing such structures are provided. Specifically, high aspect ratio carbon structures are microfabricated by pyrolyzing a patterned carbon precursor polymer. Pyrolysing the polymer preferably comprises a multi-step process in an atmosphere of inert and forming gas at high temperatures that trail the glass transition temperature (Tg) for the polymer. The surface area of the carbon microstructures is increases by nanotexturing the surface through oxygen plasma exposure, and by integrating nanoscale structures with the carbon microstructures by exposing the carbon microstructures and a catalyst to hydrocarbon gas. In a preferred embodiment, the carbon microstructures are the source of carbon gas.
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公开(公告)号：US11737507B1
公开(公告)日：2023-08-29
申请号：US18050616
申请日：2022-10-28
摘要： Sensors, actuators, energy sources, and data processing for enabling artificial intelligent (AI) integrated automated features of intelligent electronic shoes are provided. The intelligent footwear can gather information from the shoe and send the data to a user interface for monitoring the physical activities of the wearer. A smart thermal actuation system can control the internal temperature of the shoe to offer a comfortable experience to the user. Intelligent footwear can also have systems for multipurpose sensing and actuation modules, which can use energy harvested by the user locomotion or by an energy source accompanied by artificial intelligence to gather and process information for ensuring an enhanced user experience.
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公开(公告)号：US11352703B2
公开(公告)日：2022-06-07
申请号：US17234114
申请日：2021-04-19
IPC分类号： C25B1/135 , C25B11/036 , C25B15/02 , C25B11/046 , C25B9/17 , C25B11/043
摘要： Bipolar electrochemistry (BPE) concepts are used to provide a single-step and controllable process for simultaneously exfoliating a graphite source and depositing both graphene oxide and reduced graphene oxide layers on conductive substrates. A bipolar electrochemical cell can be used for a three-in-one deposition and can include two wired pieces of graphite to monitor the amount of current that passes through the bipolar electrode.
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公开(公告)号：US20210388513A1
公开(公告)日：2021-12-16
申请号：US17234114
申请日：2021-04-19
IPC分类号： C25B11/036 , C25B9/17 , C25B15/02 , C25B1/135 , C25B11/043 , C25B11/046
摘要： Bipolar electrochemistry (BPE) concepts are used to provide a single-step and controllable process for simultaneously exfoliating a graphite source and depositing both graphene oxide and reduced graphene oxide layers on conductive substrates. A bipolar electrochemical cell can be used for a three-in-one deposition and can include two wired pieces of graphite to monitor the amount of current that passes through the bipolar electrode.
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公开(公告)号：US20140031253A1
公开(公告)日：2014-01-30
申请号：US13946810
申请日：2013-07-19
申请人： Varun Penmatsa , Chunlei Wang , Hiroshi Kawarada
发明人： Varun Penmatsa , Chunlei Wang , Hiroshi Kawarada
IPC分类号： G01N33/551 , G01N33/74
CPC分类号： G01N33/551 , G01N33/582 , G01N33/74 , G01N2333/49
摘要： The potential of aptamers as ligand binding molecule have opened new avenues in the development of biosensors for proteins, such as cancer oncoproteins. Disclosed herein is a label-free detection strategy using signaling aptamer/protein binding complex for proteins, such as platelet-derived growth factor (PDGF-BB) oncoprotein. The detection mechanism is based on the release of a fluorophore (e.g., TOTO intercalating dye) from the target binding aptamer's stem structure when it captures the protein, e.g., PDGF. Amino-terminated three-dimensional carbon microarrays fabricated by pyrolyzing patterned photoresist are used as a detection platform. The sensor showed near linear relationship between the relative fluorescence difference and protein concentration even in the sub-nanomolar range with an excellent detection limit of 5 pmol. This detection strategy is promising in a wide range of applications in the detection of cancer biomarkers and other proteins.
摘要翻译： 适体作为配体结合分子的潜力为开发蛋白质生物传感器（如癌症癌蛋白）开辟了新的途径。 本文公开了使用信号转导蛋白/蛋白质结合复合物（例如血小板衍生生长因子（PDGF-BB）癌蛋白）的无标记检测策略。 检测机制基于当其捕获蛋白质例如PDGF时从靶结合适体的茎结构释放荧光团（例如，TOTO嵌入染料）。 使用通过热解图案化光致抗蚀剂制造的氨基封端的三维碳微阵列用作检测平台。 传感器即使在亚纳摩尔范围内也显示相对荧光差异和蛋白质浓度之间的近似线性关系，检出限为5 pmol。 该检测策略在肿瘤生物标志物和其他蛋白质的检测中的应用范围广泛。
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