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公开(公告)号：US06544987B2
公开(公告)日：2003-04-08
申请号：US09726314
申请日：2000-12-01
IPC分类号： A61K31535
CPC分类号： C07D401/12 , C07D207/48 , C07D209/52 , C07D211/96 , C07D213/38 , C07D279/12 , C07D413/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention concerns methods, pharmaceutical compounds, and compositions for stimulating neuroite outgrowth in nerve cells leading to nerve regeneration. These methods, compounds and compositions inhibit rotamase enzyme activity associated with binding proteins.
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公开(公告)号：US08530652B2
公开(公告)日：2013-09-10
申请号：US13267302
申请日：2011-10-06
申请人： Junhu Zhang , Chuangxing Guo , Djamal Bouzida , Liming Dong , Haitao Li , Joseph Timothy Marakovits , Anle Yang , Yufeng Hong
发明人： Junhu Zhang , Chuangxing Guo , Djamal Bouzida , Liming Dong , Haitao Li , Joseph Timothy Marakovits , Anle Yang , Yufeng Hong
IPC分类号： C07D491/00 , A01N43/90
CPC分类号： C07D487/04
摘要： Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
摘要翻译： 提供式I的吡咯吡唑化合物，包括这些化合物的组合物及其使用方法。 优选的式I化合物具有作为蛋白激酶抑制剂的活性，包括作为PAK4的抑制剂。
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3.发明申请Phosphate/sulfate ester compounds and pharmaceutical composition for inhibiting protein interacting NIMA (PIN1) 审中-公开磷酸盐/硫酸酯化合物和抑制蛋白质相互作用的药物组合物NIMA（PIN1）公开(公告)号：US20050250742A1
公开(公告)日：2005-11-10
申请号：US10792241
申请日：2004-03-03
IPC分类号： A61K31/675 , C07F9/09 , C07F9/576 , C07F9/58 , C07F9/59 , C07F9/6506 , C07F9/6509 , C07F9/6518 , C07F9/6544 , C07F9/655 , C07F9/6553 , C07F9/6558
CPC分类号： C07F9/5765 , C07F9/094 , C07F9/58 , C07F9/59 , C07F9/65068 , C07F9/650994 , C07F9/6518 , C07F9/6544 , C07F9/65515 , C07F9/65522 , C07F9/655345 , C07F9/655354 , C07F9/65583
摘要： Phosphate/sulfate ester compounds that modulate and/or inhibit the activity of protein interacting NIMA (PIN1), and to pharmaceutical compositions containing such compounds are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating disorders characterized by hypertension, inappropriate cell proliferation, infectious diseases, and neurodegenerative brain disorders, by administering effective amounts of such compounds.
摘要翻译： 描述了调节和/或抑制蛋白质相互作用的NIMA（PIN1）的活性的磷酸盐/硫酸酯化合物以及含有这些化合物的药物组合物。 本发明还涉及这些化合物和组合物的治疗或预防用途，以及通过施用有效量的这种化合物治疗以高血压，不适当的细胞增殖，感染性疾病和神经变性性脑病为特征的疾病的方法。
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公开(公告)号：US20120264751A1
公开(公告)日：2012-10-18
申请号：US13267302
申请日：2011-10-06
申请人： Junhu ZHANG , Chuangxing Guo , Djamal Bouzida , Liming Dong , Haitao Li , Joseph Timothy Marakovits , Anle Yang , Yufeng Hong
发明人： Junhu ZHANG , Chuangxing Guo , Djamal Bouzida , Liming Dong , Haitao Li , Joseph Timothy Marakovits , Anle Yang , Yufeng Hong
IPC分类号： A61K31/519 , C07D487/04 , C12N9/99 , A61K31/53 , A61K31/5377 , A61P35/00 , C07D495/04 , A61K31/506
CPC分类号： C07D487/04
摘要： Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
摘要翻译： 提供式I的吡咯吡唑化合物，包括这些化合物的组合物及其使用方法。 优选的式I化合物具有作为蛋白激酶抑制剂的活性，包括作为PAK4的抑制剂。
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公开(公告)号：US08067591B2
公开(公告)日：2011-11-29
申请号：US11813658
申请日：2005-12-28
申请人： Junhu Zhang , Chuangxing Guo , Djamal Bouzida , Liming Dong , Haitao Li , Joseph Timothy Marakovits , Anle Yang , Yufeng Hong
发明人： Junhu Zhang , Chuangxing Guo , Djamal Bouzida , Liming Dong , Haitao Li , Joseph Timothy Marakovits , Anle Yang , Yufeng Hong
IPC分类号： C07D491/00 , A01N43/90
CPC分类号： C07D487/04
摘要： Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
摘要翻译： 提供式I的吡咯吡唑化合物，包括这些化合物的组合物及其使用方法。 优选的式I化合物具有作为蛋白激酶抑制剂的活性，包括作为PAK4的抑制剂。
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公开(公告)号：US20100222342A1
公开(公告)日：2010-09-02
申请号：US11813658
申请日：2005-12-28
申请人： Junhu Zhang , Chuangxing Guo , Djamal Bouzida , Liming Dong , Haitao Li , Joseph Timothy Marakovits , Anle Yang , Yufeng Hong
发明人： Junhu Zhang , Chuangxing Guo , Djamal Bouzida , Liming Dong , Haitao Li , Joseph Timothy Marakovits , Anle Yang , Yufeng Hong
IPC分类号： A61K31/5377 , C07D495/04 , A61K31/519 , C07D403/14 , A61K31/506 , A61K31/53 , C07D239/47 , C07D401/14 , A61K31/4439 , C07D413/14 , C07D491/048 , A61K31/517 , A61P35/00
CPC分类号： C07D487/04
摘要： Pyrrole pyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
摘要翻译： 提供式I的吡咯吡唑化合物，包括这些化合物的组合物及其使用方法。 优选的式I化合物具有作为蛋白激酶抑制剂的活性，包括作为PAK4的抑制剂。
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公开(公告)号：US07772246B2
公开(公告)日：2010-08-10
申请号：US12182977
申请日：2008-07-30
申请人： Jingrong Jean Cui , Judith Gail Deal , Danlin Gu , Chuangxing Guo , Mary Catherine Johnson , Robert Steven Kania , Susan Elizabeth Kephart , Maria Angelica Linton , Indrawan James McAlpine , Mason Alan Pairish , Cynthia Louise Palmer
发明人： Jingrong Jean Cui , Judith Gail Deal , Danlin Gu , Chuangxing Guo , Mary Catherine Johnson , Robert Steven Kania , Susan Elizabeth Kephart , Maria Angelica Linton , Indrawan James McAlpine , Mason Alan Pairish , Cynthia Louise Palmer
IPC分类号： A61K31/505
CPC分类号： C07D471/04 , C07D401/14 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds of Formula (I), and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其合成及其作为Raf抑制剂的用途。
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公开(公告)号：US07884117B2
公开(公告)日：2011-02-08
申请号：US12158241
申请日：2006-12-12
申请人： Junhun Zhang , Anle Yang , Susan Elizabeth Kephart , Liming Dong , Chuangxing Guo , Yufeng Hong , Mary Catherine Johnson , Indrawan James McAlpine , Jayashree Tikhe , Haitao Li
发明人： Junhun Zhang , Anle Yang , Susan Elizabeth Kephart , Liming Dong , Chuangxing Guo , Yufeng Hong , Mary Catherine Johnson , Indrawan James McAlpine , Jayashree Tikhe , Haitao Li
IPC分类号： A61K31/422 , A61K31/4162 , C07D261/06 , C07D231/54
CPC分类号： C07D487/04
摘要： Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
摘要翻译： 提供式I的羰基氨基吡咯并吡唑化合物，包括这些化合物的组合物及其使用方法。 优选的式I化合物具有作为蛋白激酶抑制剂的活性，包括作为PAK4的抑制剂。
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公开(公告)号：US20090318440A1
公开(公告)日：2009-12-24
申请号：US12158241
申请日：2006-12-12
申请人： Junhu Zhang , Anle Yang , Susan Elizabeth Kephart , Liming Dong , Chuangxing Guo , Yufeng Hong , Mary Catherine Johnson , Indrawan James Mc Alpine , Jayashree Tikhe , Haitao Li
发明人： Junhu Zhang , Anle Yang , Susan Elizabeth Kephart , Liming Dong , Chuangxing Guo , Yufeng Hong , Mary Catherine Johnson , Indrawan James Mc Alpine , Jayashree Tikhe , Haitao Li
IPC分类号： A61K31/4162 , C07D487/04 , A61K31/5377 , A61K31/4439 , A61K31/427 , A61K31/4709 , A61K31/506 , A61K31/497
CPC分类号： C07D487/04
摘要： Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
摘要翻译： 提供式I的羰基氨基吡咯并吡唑化合物，包括这些化合物的组合物及其使用方法。 优选的式I化合物具有作为蛋白激酶抑制剂的活性，包括作为PAK4的抑制剂。
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公开(公告)号：US20090221608A1
公开(公告)日：2009-09-03
申请号：US12182977
申请日：2008-07-30
申请人： Jingrong Jean Cui , Judith Gail Deal , Danlin Gu , Chuangxing Guo , Mary Catherine Johnson , Robert Steven Kania , Susan Elizabeth Kephart , Maria Angelica Linton , Indrawan James McAlpine , Mason Alan Pairish , Cynthia Louise Palmer
发明人： Jingrong Jean Cui , Judith Gail Deal , Danlin Gu , Chuangxing Guo , Mary Catherine Johnson , Robert Steven Kania , Susan Elizabeth Kephart , Maria Angelica Linton , Indrawan James McAlpine , Mason Alan Pairish , Cynthia Louise Palmer
IPC分类号： A61K31/506 , C07D401/14 , A61K31/496 , A61P35/00
CPC分类号： C07D471/04 , C07D401/14 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds of Formula (I), and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其合成及其作为Raf抑制剂的用途。
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