公开(公告)号：US20080262018A1

公开(公告)日：2008-10-23

申请号：US12155250

申请日：2008-05-30

Applicant: Melton B. Affrime ,  Christopher R. Banfield ,  Samir K. Gupta ,  Desmond Padhi

Inventor： Melton B. Affrime ,  Christopher R. Banfield ,  Samir K. Gupta ,  Desmond Padhi

IPC: A61K31/4545 ,  A61P37/08

CPC classification number: A61K31/4545 ,  Y10S514/96

Abstract: A method of treating and/or preventing allergic and inflammatory conditions of the skin or upper and lower airway passages, e.g. seasonal allergic rhinitis, perennial allergic rhinitis, or chronic idopathic urticaria, in a human more 12 years old, by administering an amount of desloratadine, e.g. 2×2.5 mg or 5 mg/day for a time sufficient to produce a geometric mean steady state maximum plasma concentration of desloratadine in the range of about 2.90 ng/mL to about 4.54 ng/mL, or a arithmetic mean steady state maximum plasma concentration of desloratadine in the range of about 3.2 ng/mL to about 5.0 ng/mL is disclosed.

公开(公告)号：US07902208B2

公开(公告)日：2011-03-08

申请号：US12155250

申请日：2008-05-30

Applicant: Melton B. Affrime ,  Christopher R. Banfield ,  Samir K. Gupta ,  Desmond Padhi

Inventor： Melton B. Affrime ,  Christopher R. Banfield ,  Samir K. Gupta ,  Desmond Padhi

IPC: A61K31/44

CPC classification number: A61K31/4545 ,  Y10S514/96

Abstract: A method of treating and/or preventing allergic and inflammatory conditions of the skin or upper and lower airway passages, e.g. seasonal allergic rhinitis, perennial allergic rhinitis, or chronic idopathic urticaria, in a human more 12 years old, by administering an amount of desloratadine, e.g. 2×2.5 mg or 5 mg/day for a time sufficient to produce a geometric mean steady state maximum plasma concentration of desloratadine in the range of about 2.90 ng/mL to about 4.54 ng/mL, or a arithmetic mean steady state maximum plasma concentration of desloratadine in the range of about 3.2 ng/mL to about 5.0 ng/mL is disclosed.

Abstract translation: 治疗和/或预防皮肤或上，下呼吸道通路的过敏和炎症状况的方法，例如， 季节性过敏性鼻炎，常年性过敏性鼻炎或慢性感染性荨麻疹，在12岁以上的人中，通过施用一定量的去氯雷他定，例如， 2×2.5mg或5mg /天，足以产生在约2.90ng / mL至约4.54ng / mL范围内的地氯雷他定的几何平均稳态最大血浆浓度，或算术平均稳态最大血浆浓度 的脱氯雷他定在约3.2ng / mL至约5.0ng / mL的范围内。

公开(公告)号：US4944781A

公开(公告)日：1990-07-31

申请号：US378745

申请日：1989-07-12

Applicant: Donald A. Ruggirello ,  Christopher R. Banfield

Inventor： Donald A. Ruggirello ,  Christopher R. Banfield

IPC: G01N30/24

CPC classification number: G01N30/24

Abstract: An assembly for coupling a Hewlett-Packard Model HP 7673A autosampler mounted on a mounting plate to a Varian VISTA 6000 Model gas chromatograph having an injection site, includes a first bracket secured to the gas chromatograph on one side of the injection site and a second bracket secured to the gas chromatograph on the opposite side of the injection site, with the mounting plate secured to and mounted on the first and second brackets so as to permit access to the injection site by the autosampler; and securement screws for securing the mounting plate on the brackets.

公开(公告)号：US07405223B2

公开(公告)日：2008-07-29

申请号：US09760588

申请日：2001-01-16

Applicant: Melton B. Affrime ,  Christopher R. Banfield ,  Samir K. Gupta ,  Desmond Padhi

Inventor： Melton B. Affrime ,  Christopher R. Banfield ,  Samir K. Gupta ,  Desmond Padhi

IPC: A61K31/44

CPC classification number: A61K31/4545 ,  Y10S514/96

Abstract: A method of treating and/or preventing allergic and inflammatory conditions of the skin or upper and lower airway passages, e.g. seasonal allergic rhinitis, perennial allergic rhinitis, or chronic idopathic urticaria, in a human more 12 years old, by administering an amount of desloratadine, e.g. 2×2.5 mg or 5 mg/day for a time sufficient to produce a geometric mean steady state maximum plasma concentration of desloratadine in the range of about 2.90 ng/mL to about 4.54 ng/mL, or a arithmetic mean steady state maximum plasma concentration of desloratadine in the range of about 3.2 ng/mL to about 5.0 ng/mL is disclosed.

Abstract translation: 治疗和/或预防皮肤或上，下呼吸道通路的过敏和炎症状况的方法，例如， 季节性过敏性鼻炎，常年性过敏性鼻炎或慢性感染性荨麻疹，在12岁以上的人中，通过施用一定量的去氯雷他定，例如， 2x2.5mg或5mg /天，足以产生在约2.90ng / mL至约4.54ng / mL范围内的地氯雷他定的几何平均稳态最大血浆浓度，或算术平均稳态最大血浆浓度 的脱氯雷他定在约3.2ng / mL至约5.0ng / mL的范围内。