公开(公告)号：US06262119B1

公开(公告)日：2001-07-17

申请号：US09171095

申请日：1999-04-12

申请人： Antonio Ferrante ,  Alfred Poulos ,  Michael Joseph Pitt ,  Christopher John Easton ,  Merilyn Joy Sleigh ,  Deborah Ann Rathjen ,  Fred Widmer

发明人： Antonio Ferrante ,  Alfred Poulos ,  Michael Joseph Pitt ,  Christopher John Easton ,  Merilyn Joy Sleigh ,  Deborah Ann Rathjen ,  Fred Widmer

IPC分类号： A61K3120

CPC分类号： A61K31/202 ,  Y10S514/826 ,  Y10S514/861 ,  Y10S514/863 ,  Y10S514/885 ,  Y10S514/903

摘要： Method of treating or ameliorating symptoms of T-cell mediated disease wherein a composition comprising a therapeutically effective amount of a polyunsaturated fatty acid and a pharmaceutically acceptable carrier is administered to the patient. The polyunsaturated fatty acid contains 18-25 carbon atoms, 1-6 double bonds and has 1 or 2 substitutions selected from &bgr; oxa, &ggr; oxa, &bgr; thia and &ggr; thia, based on the fatty acid acyl carbon atom, or the polyunsaturated fatty acid contains 16-26 carbon atoms, 3-double bonds and is covalently coupled at the carboxylic acid group to an amino acid.

摘要翻译： 治疗或改善T细胞介导的疾病症状的方法，其中将包含治疗有效量的多不饱和脂肪酸和药学上可接受的载体的组合物施用于患者。 多不饱和脂肪酸含有18-25个碳原子，1-6个双键，并且基于脂肪酸酰基碳原子，或多不饱和脂肪酸，具有1或2个选自β氧杂，γ氧杂，β硫和γ硫的取代 含有16-26个碳原子，3-双键，并且在羧酸基团共价偶联到氨基酸。

公开(公告)号：US20140377815A1

公开(公告)日：2014-12-25

申请号：US14125259

申请日：2012-06-15

申请人： James Edward Hennessy ,  Amy Philbrook ,  Daniel Miles Bartkus ,  Christopher John Easton ,  Colin Scott ,  John G. Oakeshott ,  Hye-Kyung Kim ,  Melissa Jane Latter

发明人： James Edward Hennessy ,  Amy Philbrook ,  Daniel Miles Bartkus ,  Christopher John Easton ,  Colin Scott ,  John G. Oakeshott ,  Hye-Kyung Kim ,  Melissa Jane Latter

IPC分类号： C12N9/12 ,  C12P13/10 ,  C02F3/34 ,  C12P13/02 ,  C12P13/00

CPC分类号： C12N9/1217 ,  C02F3/342 ,  C12N9/1085 ,  C12P3/00 ,  C12P13/00 ,  C12P13/02 ,  C12P13/10 ,  C12P19/385 ,  C12Y205/00 ,  C12Y207/02002

摘要： The present invention relates to a method of producing carbamoyl phosphate, the method comprising reacting ammonia, ATP, bicarbonate and CO2, or a hydrated form thereof, in a composition in the presence of a carbamate kinase, wherein the ammonia and CO2, or hydrated form thereof, are converted to carbamate in a chemical reaction and the carbamate and ATP are converted to carbamoyl phosphate in an enzyme-catalysed reaction by the carbamate kinase, and wherein the pH of the composition is about 8 to about 12. The invention also relates to methods of producing urea.

摘要翻译： 本发明涉及一种生产氨基甲酰磷酸酯的方法，该方法包括在氨基甲酸酯激酶存在下，使氨，ATP，碳酸氢根和二氧化碳或其水合形式在组合物中反应，其中氨和CO 2或水合形式 在化学反应中转化为氨基甲酸酯，氨基甲酸酯和ATP通过氨基甲酸酯激酶在酶催化的反应中转化为氨基甲酰磷酸酯，并且其中组合物的pH为约8至约12.本发明还涉及 生产尿素的方法

公开(公告)号：US06376688B1

公开(公告)日：2002-04-23

申请号：US08817430

申请日：1997-05-29

申请人： Antonio Ferrante ,  Alfred Poulos ,  Christopher John Easton ,  Michael Joseph Pitt ,  Thomas Alistair Robertson ,  Deborah Ann Rathjen

发明人： Antonio Ferrante ,  Alfred Poulos ,  Christopher John Easton ,  Michael Joseph Pitt ,  Thomas Alistair Robertson ,  Deborah Ann Rathjen

IPC分类号： C07B4500

CPC分类号： C07C409/04 ,  C07C59/60 ,  C07C69/708 ,  C07C323/52 ,  C07C409/16 ,  C07C409/40 ,  C07C409/42

摘要： The present invention provides polyunsaturated fatty acid compounds having antimalarial and/or neutrophil stimulatory activity. The polyunsaturated fatty acids contain 18-25 carbons and 1-6 double bonds and are characterized in that they have one or two substitutions selected from the group consisting of &bgr; oxa, &ggr; oxa, &bgr; thia and &ggr; thia. It is also preferred that the polyunsaturated fatty acid compound includes a further substitution selected from the group consisting of hydroxy, hydroperoxy, peroxy, carboxymethyl substitutions or attached to an amino acid. The invention also provides a method of producing an unsaturated oxa substituted fatty acid comprising reacting an unsaturated fatty acid alcohol with a carbene that is inserted in the OH bond of the alcohol, the invention further provides a method of treating inflammation with a composition comprising at least one hydroxy, hydroperoxy or peroxy derivative of a polyunsaturated fatty acid having a C18-24 carbon chain and 1-6 cis or trans double bonds.

摘要翻译： 本发明提供具有抗疟和/或中性粒细胞刺激活性的多不饱和脂肪酸化合物。 多不饱和脂肪酸含有18-25个碳原子和1-6个双键，其特征在于它们具有一个或两个选自β-氧杂，γ-氧杂，β-硫和γ-硫的取代基。 还优选多不饱和脂肪酸化合物包括选自羟基，氢过氧基，过氧基，羧甲基取代或连接于氨基酸的另外的取代基。 本发明还提供一种生产不饱和氧杂取代脂肪酸的方法，其包括使不饱和脂肪酸醇与插入醇的OH键中的卡宾反应，本发明还提供一种用至少包含至少 具有C18-24碳链和1-6个顺式或反式双键的多不饱和脂肪酸的一种羟基，氢过氧基或过氧化物衍生物。