公开(公告)号：US20090092550A1

公开(公告)日：2009-04-09

申请号：US11572102

申请日：2005-07-15

Applicant: Max Crossley ,  Pall Thordarson ,  Neil Hunter ,  Benjamin Yap ,  Charles Andrew Collyer

Inventor： Max Crossley ,  Pall Thordarson ,  Neil Hunter ,  Benjamin Yap ,  Charles Andrew Collyer

IPC: A61K49/00 ,  C07D245/00 ,  A61K31/40

CPC classification number: C07D487/22 ,  A61K31/4178 ,  A61K47/546 ,  Y02A50/473 ,  Y02A50/481

Abstract: The present invention relates generally to targeted molecular agents (TMAs) directed to a particular organism or group of organisms and uses thereof. More particularly, the present invention provides TMAs having a targeting moiety which comprises a natural or induced auxotrophic requirement of the particular organism as a vehicle for directing an agent linked to the moiety to be delivered to the target organism. The TMAs of the present invention are useful for targeting molecules such as antimicrobial agents and diagnostic agents to selected organisms.

Abstract translation: 本发明一般涉及针对特定生物体或一组生物体的靶向分子试剂（TMA）及其用途。 更具体地，本发明提供了具有靶向部分的TMA，其包含特定生物体的天然或诱导的营养缺陷型需求，作为用于引导与要递送至靶生物体的部分连接的药剂的载体。 本发明的TMA可用于将分子例如抗微生物剂和诊断剂靶向选定的生物体。

公开(公告)号：US07319086B1

公开(公告)日：2008-01-15

申请号：US09980370

申请日：2000-05-26

Applicant: Charles Andrew Collyer ,  Neil Hunter ,  Arthur Anthony De Carlo, Jr.

Inventor： Charles Andrew Collyer ,  Neil Hunter ,  Arthur Anthony De Carlo, Jr.

IPC: A61K38/00 ,  G01N33/53

CPC classification number: A61K38/42

Abstract: The present invention relates generally to a method for the prophylaxis and treatment of infection by microorganisms in biological environments from where the microorganisms acquire iron, heme or porphyrin, generally but not exclusively for growth. Particular biological environments contemplated by the present invention include but are not limited to vascular regions and cavities as well as mucosal membranes in animals including mammals, reptiles, amphibians and fish and in avian species as well as hooves of livestock animals. The method of the present invention involves interrupting, reducing or otherwise antagonizing the interaction between a microbial-derived polypeptide, such as but not limited to a polypeptide having cysteine proteinase activity, and a porphyrin-containing molecule in such as heme. The present invention further provides agents useful in the prophylaxis and treatment of microbial infection of biological environments such as vascular regions and cavities including mucosal membranes as well as hooves involving microbial acquisition of iron, heme or porphyrin. Such agents are particularly useful as components in therapeutic compositions. Particularly important microbial infections targeted by the present invention involve infections in the oral cavity, nasopharynx, oropharynx, vagina and urethra in mammals such as humans. Other important microbial infections including infections of hooves in livestock animals such as sheep, cattle and goats.

Abstract translation: 本发明一般涉及一种预防和治疗微生物在微生物获得铁，血红素或卟啉的生物环境中的感染的方法，通常但不排他地用于生长。 本发明预期的特定生物环境包括但不限于动物中的血管区域和空腔以及动物中的粘膜，包括哺乳动物，爬行动物，两栖动物和鱼以及禽类物种以及牲畜动物的蹄。 本发明的方法包括中断，减少或以其他方式拮抗微生物来源的多肽（例如但不限于具有半胱氨酸蛋白酶活性的多肽）和诸如血红素的含卟啉分子之间的相互作用。 本发明还提供了可用于预防和治疗生物环境如血管区域和包括粘膜的空腔的微生物感染以及涉及铁，血红素或卟啉的微生物获取的蹄的药剂。 这些试剂特别可用作治疗组合物中的组分。 本发明靶向的特别重要的微生物感染涉及哺乳动物如人的口腔，鼻咽，口咽，阴道和尿道中的感染。 其他重要的微生物感染，包括畜牧动物如羊，牛和山羊的蹄感染。