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1.发明授权公开(公告)号：US10240179B2
公开(公告)日：2019-03-26
申请号：US14006586
申请日：2012-03-23
Applicant: Camilo Colaco , Ian McEntee
Inventor： Camilo Colaco , Ian McEntee
Abstract: The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular, there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress inducing stimuli. The invention further extends to the use of heat shock protein complexes produced according to the methods of the invention in the preparation of vaccine compositions for the prevention and treatment of infectious diseases and cancerous conditions.
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公开(公告)号：US07056495B2
公开(公告)日：2006-06-06
申请号：US10652212
申请日：2003-08-29
Applicant: Bruce J. Roser , Jaap Kampinga , Camilo Colaco , Julian Blair
Inventor： Bruce J. Roser , Jaap Kampinga , Camilo Colaco , Julian Blair
IPC: A61L9/04
CPC classification number: A61K9/1623 , A61K9/0021 , A61K9/145 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/475
Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
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公开(公告)号：US06811792B2
公开(公告)日：2004-11-02
申请号：US10280468
申请日：2002-10-25
Applicant: Bruce J. Roser , Jaap Kampinga , Camilo Colaco , Julian Blair
Inventor： Bruce J. Roser , Jaap Kampinga , Camilo Colaco , Julian Blair
IPC: A61F202
CPC classification number: A61K9/1623 , A61K9/0021 , A61K9/145 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/475
Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
Abstract translation: 本发明包括用于将生物活性材料弹性施用于皮下和皮内组织的固体剂量递送载体，所述递送载体的尺寸和形状用于穿透表皮。 递送载体还包含负载有生物活性材料并能够原位释放生物活性物质的稳定多元醇玻璃。 本发明还包括制备和使用本发明的固体剂量递送载体的方法。
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公开(公告)号：US06596702B2
公开(公告)日：2003-07-22
申请号：US10161855
申请日：2002-06-03
Applicant: Jaap Kampinga , Camilo Colaco
Inventor： Jaap Kampinga , Camilo Colaco
IPC: A61K31715
CPC classification number: A23L2/60 , A23L2/395 , A23L33/16 , Y10S426/81
Abstract: The invention provides sports beverages which supply a readily metabolizable, natural carbohydrate, trehalose. The use of trehalose provides twice the concentration of glucose molecules for immediate energy compared to monosaccharide solutions of the same osmolarity.
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5.发明授权Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery 失效用于改善生物活性剂用于粘膜递送的生物利用度的方法和组合物公开(公告)号：US06517860B1
公开(公告)日：2003-02-11
申请号：US09000857
申请日：1997-12-30
Applicant: Bruce J. Roser , Ian Sanderson , Jaap Kampinga , Camilo Colaco
Inventor： Bruce J. Roser , Ian Sanderson , Jaap Kampinga , Camilo Colaco
IPC: A61F1300
CPC classification number: A61K9/145 , A61K9/0048 , A61K9/006 , A61K9/0075 , A61K47/26 , Y10S514/958
Abstract: The invention encompasses compositions for increased bioavailability through mucosal delivery comprising, preferably in powder form, an intimate mixture of an effective amount of a bioactive agent and a hydrophobically derivatized carbohydrate. The compositions can also contain a surface active agent preferably for delivery to gastrointestinal mucosa and ocular delivery.
Abstract translation: 本发明包括通过粘膜递送提高生物利用度的组合物，优选以粉末形式包含有效量的生物活性剂和疏水衍生的碳水化合物的紧密混合物。 组合物还可以含有表面活性剂，优选用于递送至胃肠粘膜和眼部递送。
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Patent Agency Ranking
公开(公告)号：US06290991B1
公开(公告)日：2001-09-18
申请号：US08349029
申请日：1994-12-02
Applicant: Bruce J. Roser , Jaap Kampinga , Camilo Colaco , Julian Blair
Inventor： Bruce J. Roser , Jaap Kampinga , Camilo Colaco , Julian Blair
IPC: A61K950
CPC classification number: A61K9/1623 , A61K9/0021 , A61K9/145 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/475
Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
Abstract translation: 本发明包括用于将生物活性材料弹性施用于皮下和皮内组织的固体剂量递送载体，所述递送载体的尺寸和形状用于穿透表皮。 递送载体还包含负载有生物活性材料并能够原位释放生物活性物质的稳定多元醇玻璃。 本发明还包括制备和使用本发明的固体剂量递送载体的方法。
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7.发明授权公开(公告)号：US06586006B2
公开(公告)日：2003-07-01
申请号：US09755737
申请日：2001-01-05
Applicant: Bruce J. Roser , Camilo Colaco , Mohammed A. Z. Jerrow , Julian Blair , Jaap Kampinga , James Lewis Wardell , John Alistair Duffy
Inventor： Bruce J. Roser , Camilo Colaco , Mohammed A. Z. Jerrow , Julian Blair , Jaap Kampinga , James Lewis Wardell , John Alistair Duffy
IPC: A61K914
CPC classification number: A61K9/0021 , A61K9/145 , Y02A50/463
Abstract: The present invention encompasses solid dose delivery systems for administration of guest substances. Preferred delivery systems are suitable for delivery of bioactive materials to subcutaneous and intradermal, intramuscular, intravenous tissue, the delivery system being sized and shaped for penetrating the epidermis. The delivery systems comprises a vitreous vehicle loaded with the guest substance and capable of releasing the guest substance in situ at various controlled rates. The present invention further includes methods of making and using the solid dose delivery systems.
Abstract translation: 本发明包括用于施用客体物质的固体剂量递送系统。 优选的递送系统适于将生物活性物质递送到皮下和皮内，肌内，静脉内组织，所述递送系统的尺寸和形状适于穿透表皮。 输送系统包括装载客体物质的玻璃体，并且能够以各种控制的速率原位释放客体物质。 本发明还包括制备和使用固体剂量递送系统的方法。
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公开(公告)号：US06331310B1
公开(公告)日：2001-12-18
申请号：US09628380
申请日：2000-08-01
Applicant: Bruce J. Roser , Jaap Kampinga , Camilo Colaco , Julian Blair
Inventor： Bruce J. Roser , Jaap Kampinga , Camilo Colaco , Julian Blair
IPC: A61F202
CPC classification number: A61K9/1623 , A61K9/0021 , A61K9/145 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/475
Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
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公开(公告)号：US09593143B2
公开(公告)日：2017-03-14
申请号：US13062465
申请日：2009-09-07
Applicant: Camilo Colaco , Kamram Salim
Inventor： Camilo Colaco , Kamram Salim
CPC classification number: C07K1/18 , A61K39/0011 , A61K39/04 , A61K39/095 , A61K2039/5256 , C07K14/00 , C07K2319/30 , C12N2710/14143 , C12N2760/16122 , C12N2770/24222 , Y02A50/394 , Y02A50/397 , Y02A50/403 , Y02A50/466 , Y02A50/478
Abstract: The present invention provides a method for the purification of complexes comprising a stress protein complexed to a peptide or peptide fragment, from a source mixture, typically a cell lysate. The improved method of the invention provides for protein complexes to be purified using ion exchange based methods, without the need to use chemicals such as chaotropes and ampholytes. The purified complexes can be used as the immunogenic determinant in vaccine compositions for the treatment or prevention of infectious diseases or cancerous conditions.
Abstract translation: 本发明提供了一种从源混合物（通常为细胞裂解物）纯化包含与肽或肽片段复合的应激蛋白的复合物的方法。 本发明的改进方法提供使用基于离子交换的方法纯化的蛋白质复合物，而不需要使用诸如离液剂和两性电解质的化学品。 纯化的复合物可用作疫苗组合物中用于治疗或预防感染性疾病或癌症病症的免疫原性决定簇。
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公开(公告)号：US20050276845A1
公开(公告)日：2005-12-15
申请号：US11134573
申请日：2005-05-20
Applicant: Bruce Roser , Jaap Kampinga , Camilo Colaco , Julian Blair
Inventor： Bruce Roser , Jaap Kampinga , Camilo Colaco , Julian Blair
CPC classification number: A61K9/1623 , A61K9/0021 , A61K9/145 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/475
Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
Abstract translation: 本发明包括用于将生物活性材料弹性施用于皮下和皮内组织的固体剂量递送载体，所述递送载体的尺寸和形状用于穿透表皮。 递送载体还包含负载有生物活性材料并能够原位释放生物活性物质的稳定多元醇玻璃。 本发明还包括制备和使用本发明的固体剂量递送载体的方法。
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