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    Methods for correcting mitotic spindle defects and optimizing preimplantation embryonic developmental rates associated with somatic cell nuclear transfer in animals
    1.
    发明申请
    Methods for correcting mitotic spindle defects and optimizing preimplantation embryonic developmental rates associated with somatic cell nuclear transfer in animals 审中-公开
    纠正有丝分裂纺锤体缺陷和优化与动物体细胞核转移相关的植入前胚胎发育率的方法

    公开(公告)号：US20060037086A1

    公开(公告)日：2006-02-16

    申请号：US11003006

    申请日：2004-12-03

    申请人： Gerald Schatten ,  Calvin Simerly ,  Christopher Navara

    发明人： Gerald Schatten ,  Calvin Simerly ,  Christopher Navara

    IPC分类号： A01K67/00

    CPC分类号： A01K67/0273 ,  A01K2227/106 ,  C12N5/0604 ,  C12N5/0609 ,  C12N15/877 ,  C12N15/8776 ,  C12N2517/04

    摘要： The present invention is directed to various methodologies to make NT a practical procedure for animals, specifically, primates including human and non-human primates. Furthermore, the methods and molecular components provided by the present invention provide a practical means for producing embryos with desired characteristics. In a specific embodiment, the methodology of the present invention comprises introducing nuclei having desired characteristics along with one or more molecular components into an enucleated egg, thus creating a nuclear transfer construct, culturing the egg to produce a viable embryo, transferring the embryo to the oviducts of a female, and producing a cloned animal.

    摘要翻译： 本发明涉及使NT成为动物，特别是包括人和非人灵长类动物的灵长类动物的实用程序的各种方法。 此外，本发明提供的方法和分子组分提供了生产具有所需特征的胚胎的实用手段。 在具体实施方案中，本发明的方法包括将具有所需特征的核以及一种或多种分子成分引入去核卵中，从而产生核转移构建体，培养卵以产生活的胚胎，将胚胎转移至 雌性输卵管，并产生克隆的动物。