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公开(公告)号：US20210324013A1
公开(公告)日：2021-10-21
申请号：US17262327
申请日：2019-05-28
Inventor： Nopporn SITTISOMBUT , Malinee SAE-LIM , Nicha CHAROENSRI , Poonsook KEELAPANG
IPC: C07K14/005 , C12N7/00 , A61K39/12 , A61P31/14
Abstract: The present disclosure associates to a modified and expressed virus-like particles. Particularly, the virus-like particle is capable of eliciting immune response in a mammal upon administrating a pharmaceutically efficient dosage to the mammal. The virus-like particle comprises a modified form of M and E structural proteins of flavivirus. Further, the virus-like particle comprises an amino acids sequence substantially corresponding to a sequence setting forth in SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3 or SEQ ID NO. 4, wherein conserved and internally located His at multiple positions of the M and E proteins are substituted with uncharged residues, and other secretion-enhancing substitutions are introduced.
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公开(公告)号：US20160280726A1
公开(公告)日：2016-09-29
申请号：US14442672
申请日：2013-10-30
Applicant: CHIANG MAI UNIVERSITY
Inventor： Puttinan MEEPOWPAN , Winita PUNYODOM , Robert MOLLOY
IPC: C07F7/22
CPC classification number: C07F7/2224 , C07F7/2296
Abstract: A synthetic process of producing liquid tin(II) alkoxides for use as either catalysts in the synthesis of lactide or as initiators in the polymerization of cyclic ester monomers to yield biodegradable polyesters is described. The synthetic process employs anhydrous tin(II) chloride dissolved in n-heptane mixed with dry diethylamine. Alcohols, ROH, in which the R groups are n-C4H9, n-C6H13, and n-C8H17 are added to the reaction mixture and stirred for 12 hours. The reaction mixture is then filtered under nitrogen or argon before being evaporated to dryness to yield the three tin(II) alkoxides, namely: tin(II) n-butoxide, tin(II) n-hexoxide, and tin(II) n-octoxide. All three tin(II) alkoxides are viscous, dark yellow liquids which are highly soluble in most common organic solvents. Furthermore, they can all be stored under an inert atmosphere for long periods without any significant change in their reactivity and therefore, in their effectiveness as catalysts/initiators.
Abstract translation: 描述了用于合成丙交酯中的催化剂或作为环状酯单体聚合反应以产生可生物降解的聚酯的引发剂的液态锡（II）的合成方法。 合成方法使用溶解在与无水二乙胺混合的正庚烷中的无水氯化锡（II）。 将R基团为n-C 4 H 9，n-C 6 H 13和n -C 8 H 17的醇，ROH加入到反应混合物中并搅拌12小时。 然后将反应混合物在氮气或氩气下过滤，然后蒸发至干，得到三种锡（II）醇盐，即：正丁醇锡（II），正己氧基锡（II）和锡（II） 辛烷 所有三种锡（II）醇盐是粘稠的深黄色液体，其在大多数常见的有机溶剂中是高度可溶的。 此外，它们都可以在惰性气氛下长时间储存，而且它们的反应性没有任何显着变化，因此它们作为催化剂/引发剂的有效性。
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Patent Agency Ranking
公开(公告)号：US20250057920A1
公开(公告)日：2025-02-20
申请号：US18249932
申请日：2022-03-22
Applicant: CHIANG MAI UNIVERSITY , SURANAREE UNIVERSITY OF TECHNOLOGY
Inventor： Chatchai TAYAPIWATANA , Umpa YASAMUT , Montarop YAMABHAI , Vannajan Sanghiran LEE
Abstract: A modified or bioengineered protein of a modified interferon gamma (IFN-γ) related to at least one modification. Preferably, the modified IFN-γ comprises at least one modification of an amino acid located at a position of 27 to 40 of a sequence as setting forth in SEQ ID NO. 1. The modified IFN-γ is capable of initiating cellular signaling towards an immune response upon being administered to a subject.
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公开(公告)号：US20230002796A1
公开(公告)日：2023-01-05
申请号：US16631048
申请日：2018-07-31
Inventor： Chartchai KHANONGNUCH , Kridsada UNBAN , Saisamorn LUMYONG , Ronachai PRATANAPHON , Wasu PATHOM-AREE , Wannisa RIEANTRAKOONCHAI , Apinun KANPIENGJAI
Abstract: Induction mutagenesis in lactic acid bacteria for D(−) lactic acid production from starch was performed and the stable mutant strain of Lactobacillus plantarum improved by the molecular biological technique can be used in production of high optically pure D(−) lactic acid directly from various kinds of starch as a carbon source. Those starch substrates are included cassava starch, corn starch and rice starch, etc. The fermentation product is high optically pure D(−) lactic acid up to 90.0-99.0% which is able to apply in bioplastic and pharmaceutical industries.
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公开(公告)号：US12098165B2
公开(公告)日：2024-09-24
申请号：US17262327
申请日：2019-05-28
Inventor： Nopporn Sittisombut , Malinee Sae-Lim , Nicha Charoensri , Poonsook Keelapang
IPC: C07K14/005 , A61K39/00 , A61K39/12 , A61P31/14 , C12N7/00
CPC classification number: C07K14/005 , A61K39/12 , A61P31/14 , C12N7/00 , A61K2039/5258 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/24171
Abstract: Modified and expressed virus-like particles are described that are capable of eliciting immune response in a mammal upon administrating a pharmaceutically efficient dosage to the mammal. The virus-like particle comprises a modified form of M and E structural proteins of flavivirus. Further, the virus-like particle comprises an amino acids sequence substantially corresponding to a sequence set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4, wherein conserved and internally located His at multiple positions of the M and E proteins are substituted with uncharged residues, and other secretion-enhancing substitutions are introduced.
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6.发明申请公开(公告)号：US20170333390A1
公开(公告)日：2017-11-23
申请号：US15622639
申请日：2017-06-14
Applicant: CHIANG MAI UNIVERSITY , COMMISSION ON HIGHER EDUCATION
Inventor： Prachya KONGTAWELERT
IPC: A61K31/36 , A23L33/105 , A61K45/06
CPC classification number: A61K31/36 , A23L33/105 , A23V2002/00 , A61K45/06 , A23V2250/21 , A23V2200/324 , A23V2200/316
Abstract: A composition (e.g., phytochemical composition) including sesamin, the composition exhibiting anti-inflammatory, anti-cytokine storm, connective tissue preservation, anti-viral, and/or other properties in biological tissue. The phytochemical composition therapeutically affects a pro-inflammatory cytokine condition, for instance facilitating or effectuating decrease in a quantity of a pro-inflammatory cytokine, for example, interleukin-1 and tumor necrosis-alpha. The phytochemical composition facilitates or effectuates an increase in quantity of an anti-inflammatory cytokines. The phytochemical composition can additionally facilitate a connective tissue extracellular matrix (ECM) preservation effect. The phytochemical composition can also inhibit an action of a viral neuraminidase, for example, the influenza A virus neuraminidase. Uses of sesamin for manufacture of phytochemical compositions having predetermined concentrations of sesamin include facilitating a decrease in quantity of pro-inflammatory cytokines, an increase in anti-inflammatory cytokines, a connective tissue anti-degenerative effect, and/or an inhibition of viral neuraminidase within the living organism. Manufacturing processes for the phytochemical compositions are also described.
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公开(公告)号：US09637507B2
公开(公告)日：2017-05-02
申请号：US14442672
申请日：2013-10-30
Applicant: CHIANG MAI UNIVERSITY
Inventor： Puttinan Meepowpan , Winita Punyodom , Robert Molloy
CPC classification number: C07F7/2224 , C07F7/2296
Abstract: A synthetic process of producing liquid tin(II) alkoxides for use as either catalysts in the synthesis of lactide or as initiators in the polymerization of cyclic ester monomers to yield biodegradable polyesters is described. The synthetic process employs anhydrous tin(II) chloride dissolved in n-heptane mixed with dry diethylamine. Alcohols, ROH, in which the R groups are n-C4H9, n-C6H13, and n-C8H17 are added to the reaction mixture and stirred for 12 hours. The reaction mixture is then filtered under nitrogen or argon before being evaporated to dryness to yield the three tin(II) alkoxides, namely: tin(II) n-butoxide, tin(II) n-hexoxide, and tin(II) n-octoxide. All three tin(II) alkoxides are viscous, dark yellow liquids which are highly soluble in most common organic solvents. Furthermore, they can all be stored under an inert atmosphere for long periods without any significant change in their reactivity and, therefore, in their effectiveness as catalysts/initiators.
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