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公开(公告)号：US09617305B2
公开(公告)日：2017-04-11
申请号：US14124286
申请日：2012-06-08
Applicant: Mark G. Currie , Daniel P. Zimmer , Angelika Fretzen , Marco Kessler , Brian M. Cali
Inventor： Mark G. Currie , Daniel P. Zimmer , Angelika Fretzen , Marco Kessler , Brian M. Cali
Abstract: The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention.
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公开(公告)号：US07960544B2
公开(公告)日：2011-06-14
申请号：US12097616
申请日：2006-12-18
Applicant: Wilmin Bartolini , Brian M. Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
Inventor： Wilmin Bartolini , Brian M. Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
IPC: C07D403/06 , C07D239/26 , C07D471/04 , C07D401/06 , C07D271/06 , C07D271/10 , C07D417/06 , C07D413/06 , C07D263/32 , C07D261/08
CPC classification number: C07D209/42 , C07D209/30 , C07D401/06 , C07D409/06 , C07D417/06
Abstract: Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.
Abstract translation: 具有作为FAAH抑制剂的活性的吲哚被描述为具有作为DAO抑制剂的活性的吲哚和吲哚衍生物。
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公开(公告)号：US20140348942A1
公开(公告)日：2014-11-27
申请号：US14124286
申请日：2012-06-08
Applicant: Mark G. Currie , Daniel P. Zimmer , Angelika Fretzen , Marco Kassler , Brian M. Cali
Inventor： Mark G. Currie , Daniel P. Zimmer , Angelika Fretzen , Marco Kassler , Brian M. Cali
Abstract: The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention.
Abstract translation: 本发明提供了治疗下消化道疾病的药物组合物和方法，包括炎症性肠病（IBD），憩室炎，结肠癌，炎症性疾病，肥胖，充血性心力衰竭，良性前列腺增生（BPH），疼痛，盐滞留或流体 保留。
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Patent Agency Ranking
公开(公告)号：US20090264653A1
公开(公告)日：2009-10-22
申请号：US12097616
申请日：2006-12-18
Applicant: Wilmin Bartolini , Brian M Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
Inventor： Wilmin Bartolini , Brian M Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
IPC: C07D413/14 , C07D209/04 , C07D235/00 , C07D403/04 , C07D215/02 , C07D471/02
CPC classification number: C07D209/42 , C07D209/30 , C07D401/06 , C07D409/06 , C07D417/06
Abstract: Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.
Abstract translation: 具有作为FAAH抑制剂活性的吲哚被描述为具有作为DAO抑制剂的活性的吲哚和吲哚衍生物。
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公开(公告)号：US09527887B2
公开(公告)日：2016-12-27
申请号：US14124282
申请日：2012-06-08
Applicant: Mark G. Currie , Daniel P. Zimmer , Angelika Fretzen , Marco Kessler , Brian M. Cali
Inventor： Mark G. Currie , Daniel P. Zimmer , Angelika Fretzen , Marco Kessler , Brian M. Cali
Abstract: The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.
Abstract translation: 本发明提供了治疗较低胃肠道疾病（包括肠易激综合征和便秘）的药物组合物和方法。
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公开(公告)号：US20140342996A1
公开(公告)日：2014-11-20
申请号：US14124282
申请日：2012-06-08
Applicant: Mark G. Currie , Daniel P. Zimmer , Angelika Fretzen , Marco Kessler , Brian M. Cali
Inventor： Mark G. Currie , Daniel P. Zimmer , Angelika Fretzen , Marco Kessler , Brian M. Cali
Abstract: The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.
Abstract translation: 本发明提供了治疗较低胃肠道疾病（包括肠易激综合征和便秘）的药物组合物和方法。
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公开(公告)号：US07205329B2
公开(公告)日：2007-04-17
申请号：US11183626
申请日：2005-07-18
Applicant: Yueh-Tyng Chien , G. Todd Milne , Mark G. Currie , John Jeffrey Talley , Brian M. Cali , Barbara Chen , Craig Zimmerman , Jing Jing Yang
Inventor： Yueh-Tyng Chien , G. Todd Milne , Mark G. Currie , John Jeffrey Talley , Brian M. Cali , Barbara Chen , Craig Zimmerman , Jing Jing Yang
IPC: A61K31/405 , C07D209/12
CPC classification number: C07D409/06 , C07D209/42
Abstract: Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
Abstract translation: 描述了CRTH2受体的调节剂及其在治疗各种疾病（包括哮喘）中的用途。
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8.发明授权Isolated nucleic acid molecule encoding a regulator of fungal gene expression 有权分离的核酸分子编码真菌基因表达的调节剂公开(公告)号：US06806082B2
公开(公告)日：2004-10-19
申请号：US10029180
申请日：2001-12-22
Applicant: Brian M. Cali , Douglas Holtzman , Kevin T. Madden , G. Todd Milne , Amir Sherman , Jeffrey C. Silva , Joshua Trueheart , Lixin Zhang
Inventor： Brian M. Cali , Douglas Holtzman , Kevin T. Madden , G. Todd Milne , Amir Sherman , Jeffrey C. Silva , Joshua Trueheart , Lixin Zhang
IPC: C12N510
CPC classification number: C07K14/385 , C07K14/38
Abstract: The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.
Abstract translation: 本发明涉及真菌基因表达的调节剂及其在商业和医学应用中的应用。 更具体地，本发明涉及涉及酶，次生代谢物和其它有用产物的生产的真菌基因调节剂，以及参与真菌侵袭的基因的调节剂。 本发明提供了真菌基因表达的新型调节剂，以及在商业和医学应用中使用调节基因的方法。
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