公开(公告)号：US10267873B2

公开(公告)日：2019-04-23

申请号：US13988862

申请日：2011-11-29

申请人： Bernhard Gleich ,  Juergen Erwin Rahmer

发明人： Bernhard Gleich ,  Juergen Erwin Rahmer

IPC分类号： G01R33/28 ,  G01R33/44 ,  A61B5/05 ,  G01R33/12

摘要： An apparatus for operation in a magnetic particle imaging mode for influencing and/or detecting magnetic particles in a field of view, and for operation in a magnetic resonance imaging mode, includes a selector having a selection field signal generator and selection field coils, a driver having a drive field signal generator and drive field coils for changing the position in space of the two sub-zones in the field of view by a magnetic drive field so that the magnetization of magnetic particles changes locally, and a focuser having a focus field signal generator and a focus field coil unit for changing the position in space of the field of view by a magnetic focus field. The focus field coil unit includes at least six focus field coils arranged for generating magnetic focus field components in different directions, where a first set of at least three focus field coils is arranged on a first side of the field of view and a second set of at least three focus field coils is arranged on a second side of the field of view opposite said first side.

公开(公告)号：US09480413B2

公开(公告)日：2016-11-01

申请号：US12696911

申请日：2010-01-29

申请人： Bernhard Gleich ,  Juergen Weizenecker ,  Nielsen Tim

发明人： Bernhard Gleich ,  Juergen Weizenecker ,  Nielsen Tim

IPC分类号： A61B5/05

CPC分类号： A61B5/05 ,  A61B5/0515

摘要： A system for determining the spatial distribution of magnetic particles in an examination area. Magnetic field generator generates a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength in which the magnetization of the particles is in a state of non-saturation, whereas they are in a state of saturation in the remaining region. By an arrangement to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by a detector. At least one of the magnetic field generator, the arrangement and the detector are arranged at least partially on a medical instrument.

摘要翻译： 一种用于确定检查区域中磁性颗粒的空间分布的系统。 磁场发生器产生具有低场强的至少一个区域的空间不均匀梯度磁场，其中颗粒的磁化处于不饱和状态，而在剩余区域中它们处于饱和状态。 通过在检查区域内移动具有低场强度的区域的装置，可以通过检测器从外部检测磁性粒子的磁化强度的变化。 至少一个磁场发生器，布置和检测器至少部分地布置在医疗器械上。

公开(公告)号：US09357943B2

公开(公告)日：2016-06-07

申请号：US13139747

申请日：2009-12-11

申请人： Bernhard Gleich ,  Juergen Weizenecker

发明人： Bernhard Gleich ,  Juergen Weizenecker

IPC分类号： A61B5/055 ,  A61B5/05 ,  A61B5/02 ,  G01R33/12 ,  A61B5/00

CPC分类号： A61B5/05 ,  A61B5/02007 ,  A61B5/0515 ,  A61B5/7242 ,  G01R33/1269

摘要： An arrangement (10) and a method for imaging an object including a vessel (400), using magnetic particle imaging is provided. An image of the vessel (400) is reconstructed based on a known concentration of the magnetic particles (100) within the vessel (400) and on vessel tree data about the progression of said vessel (400). The reconstruction comprises defining cylinder elements (440) around an approximated image and stepwise and separately adapting the radii of the cylinder elements by integrating over the signal intensity of the cylinder elements, wherein the radii are adapted such that the integrated signal intensity over the cylinder elements equals the intensity expected from the known concentration of the magnetic particles in the vessel.

摘要翻译： 提供一种使用磁粉成像的装置（10）和包括容器（400）的物体成像方法。 基于容器（400）内的已知浓度的磁性颗粒（100）和关于所述容器（400）的进展的容器树数据重建血管（400）的图像。 重建包括围绕近似图像定义圆柱体元件（440），并且逐步地并且通过在圆柱体元件的信号强度上积分来单独适应气缸元件的半径，其中半径适于使得圆柱体元件上的积分信号强度 等于从容器中已知浓度的磁性颗粒预期的强度。

公开(公告)号：US09031633B2

公开(公告)日：2015-05-12

申请号：US13132322

申请日：2009-12-02

申请人： Juergen Erwin Rahmer ,  Jeurgen Weizenecker ,  Bernhard Gleich

发明人： Juergen Erwin Rahmer ,  Jeurgen Weizenecker ,  Bernhard Gleich

IPC分类号： A61B5/05 ,  G01R33/12 ,  G01N27/72

CPC分类号： A61B5/05 ,  A61B5/0515

摘要： In Magnetic Particle Imaging (MPI) the reconstruction requires the knowledge of a so called system function. This function describes the relation between spatial position and frequency response and is currently measured once for a scanner set-up and a tracer material. For reasonable resolutions and fields of view the system function becomes quite large, resulting in large acquisition times to obtain reasonable signal-to-noise. However, the system function has a number of properties which can be used to improve signal-to-noise. According to the present invention use is made of the spatial symmetry and/or identical responses at different frequencies for this purpose.

摘要翻译： 在磁性粒子成像（MPI）中，重建需要知道所谓的系统功能。 该功能描述了空间位置和频率响应之间的关系，目前为扫描仪设置和示踪材料测量一次。 对于合理的分辨率和视野，系统功能变得相当大，导致获得合理的信噪比的大的采集时间。 然而，系统功能具有许多可用于改善信噪比的特性。 根据本发明，为此目的使用不同频率的空间对称性和/或相同响应。

公开(公告)号：US08285365B2

公开(公告)日：2012-10-09

申请号：US12438144

申请日：2007-08-20

申请人： Steffen Weiss ,  Bernhard Gleich

发明人： Steffen Weiss ,  Bernhard Gleich

IPC分类号： A61B5/05

CPC分类号： G01R33/34084 ,  A61B5/042 ,  A61B5/06 ,  A61B18/1492 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2562/222 ,  G01R33/287 ,  G01R33/288 ,  G01R33/34053 ,  G01R33/3628

摘要： A interventional device for RF ablation for use in a RF electrical and/or magnetic field especially of a MR imaging system is disclosed, comprising an ablation catheter which is preferably trackable or can be guided or visualized in the image generated by the MR imaging system by means of a MR micro-coil (102), and which is provided with an ablation electrode (101). The interventional device further comprises a transmission path (103) with line segments (104′, 104″) and transformers (105) therebetween, for connecting the MR micro-coil (102) in a differential mode with a MR receiver (108) and for connecting a RF amplifier (107) in a common mode with the ablation electrode (101) for conveying RF ablation power.

摘要翻译： 公开了用于RF电和/或磁场特别是MR成像系统的用于RF消融的介入装置，其包括消融导管，该消融导管优选可追踪或可由MR成像系统由图像生成的图像中引导或可视化 MR微型线圈（102）的装置，并且设置有消融电极（101）。 介入装置还包括在其间具有线段（104'，104“）和变压器（105）的传输路径（103），用于以差分模式将MR微型线圈（102）与MR接收器（108）和 用于将共模的RF放大器（107）与用于传送RF消融功率的消融电极（101）连接。

公开(公告)号：US20120153948A1

公开(公告)日：2012-06-21

申请号：US13389900

申请日：2010-08-16

申请人： Jurgen Erwin Rahmer ,  Bernhard Gleich ,  Jurgen Weizenecker

发明人： Jurgen Erwin Rahmer ,  Bernhard Gleich ,  Jurgen Weizenecker

IPC分类号： G01R33/44

CPC分类号： A61B5/05 ,  A61B5/0515

摘要： The present invention relates to an apparatus (100) for influencing and/or detecting magnetic particles in a field of view (28), wherein the field of view (28) comprises at least one sub field of interest covering at least a portion of an object of interest containing magnetic particles. The apparatus (100) applying the known principle of Magnetic Particle Imaging (MPI) comprises selection means for generating a magnetic selection field (50) having the known field pattern showing a field free point (FFP), drive means for changing the position in space of the FFP by means of a magnetic drive field, receiving means for acquiring detection signals depending on the magnetization of the magnetic particles within the field of view (28), a control unit (150) for controlling a signal receiving unit (140) comprised in the receiving means for acquiring a set of high resolution detection signals and a set of low resolution detection signals, wherein the set of high resolution detection signals depends on the magnetization of at least one subfield of interest and the set of low resolution detection signals depends on the magnetization of at least one adjacent subfield being arranged adjacent to the at least one subfield of interest, and a reconstruction unit (152) for reconstructing a particle distribution quantity depending on the set of high resolution detection signals and the set of low resolution detection signals. The present invention further relates to a corresponding method as well as to a computer program.

摘要翻译： 本发明涉及一种用于在视场（28）中影响和/或检测磁性颗粒的设备（100），其中视场（28）包括至少一个感兴趣的子场，其覆盖至少一部分 感兴趣的物体包含磁性颗粒。 应用已知的磁性粒子成像原理（MPI）的装置（100）包括选择装置，用于产生具有示出场自由点（FFP）的已知场模式的磁选择场（50），用于改变空间位置的驱动装置 通过磁驱动场的FFP的接收装置，用于获取取决于视野内的磁性颗粒的磁化强度的检测信号的接收装置，用于控制信号接收单元（140）的控制单元（150），包括： 在用于获取一组高分辨率检测信号和一组低分辨率检测信号的接收装置中，其中该组高分辨率检测信号取决于至少一个感兴趣的子场的磁化，并且该组低分辨率检测信号取决于 在与至少一个感兴趣的子场相邻地布置的至少一个相邻子场的磁化上，以及用于重构的重建单元（152） 根据高分辨率检测信号和一组低分辨率检测信号来设定粒子分布量。 本发明还涉及相应的方法以及计算机程序。

公开(公告)号：US08188732B2

公开(公告)日：2012-05-29

申请号：US12519628

申请日：2007-12-17

申请人： Bernhard Gleich ,  Juergen Weizenecker

发明人： Bernhard Gleich ,  Juergen Weizenecker

IPC分类号： G01R33/12 ,  G01N27/72

CPC分类号： A61B5/05 ,  A61B5/0515

摘要： An arrangement and a method for influencing and/or detecting and/or locating magnetic particles in a region of action include a driver generating a magnetic drive field so that magnetization of the magnetic particles changes. The magnetic particles include first and second magnetic particles. The arrangement further include a receiver having a first receiving probe providing a first signal and a second receiving probe providing a second signal. A detector determines signal features arising from the first particle in the first signal and in the second signal.

摘要翻译： 在动作区域中影响和/或检测和/或定位磁性颗粒的装置和方法包括产生磁驱动场的驱动器，使得磁性颗粒的磁化改变。 磁性颗粒包括第一和第二磁性颗粒。 该装置还包括具有提供第一信号的第一接收探头和提供第二信号的第二接收探头的接收机。 检测器确定在第一信号和第二信号中由第一粒子产生的信号特征。

公开(公告)号：US08183861B2

公开(公告)日：2012-05-22

申请号：US12519623

申请日：2007-12-17

申请人： Bernhard Gleich ,  Juergen Weizenecker

发明人： Bernhard Gleich ,  Juergen Weizenecker

IPC分类号： G01N27/72 ,  G01R33/12

CPC分类号： A61B5/05 ,  A61B5/0515

摘要： An arrangement for influencing and/or detecting magnetic particles includes a selector for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action. A driver changes the position in space of the two sub-zones in the region of action by a magnetic drive field so that the magnetization of the magnetic particles changes locally, and a receiver acquires signals. The signals depend on the magnetization in the region of action, and the magnetization is influenced by the change in the position in space of the first and second sub-zone. The receiver has first and second compensators, each including a compensation coil.

摘要翻译： 用于影响和/或检测磁性颗粒的装置包括：选择器，用于产生具有其磁场强度空间中的图案的磁选择场，使得具有低磁场强度的第一子区域和具有低磁场强度的第二子区域 在作用区域形成较高的磁场强度。 驱动器通过磁驱动场改变动作区域中的两个子区域的空间位置，使得磁性粒子的磁化在局部变化，并且接收器获取信号。 信号取决于作用区域中的磁化强度，并且磁化受到第一和第二子区域的空间位置变化的影响。 接收器具有第一和第二补偿器，每个补偿器包括补偿线圈。

公开(公告)号：US20100243574A1

公开(公告)日：2010-09-30

申请号：US12739177

申请日：2008-10-24

申请人： Denis Markov ,  Hans Marc Bert Boeve ,  Bernhard Gleich ,  Juergen Weizenecker

发明人： Denis Markov ,  Hans Marc Bert Boeve ,  Bernhard Gleich ,  Juergen Weizenecker

IPC分类号： B03C1/033 ,  B03C1/025

CPC分类号： B03C1/286 ,  A61B5/0515 ,  B03C1/01 ,  B03C1/0335 ,  B03C2201/18 ,  G01N30/0005

摘要： A separator system with a separator column and a method of fractionating magnetic particles, preferably using field-flow fractionation is proposed, which allows for more effective fractionation of magnetic particles with respect to their dynamic magnetic response in a wide frequency and amplitude range of an applied magnetic field, in particular relevant for magnetic particle imaging (MPI).

摘要翻译： 提出了一种具有隔离柱的分离器系统和优选使用场流分级分离磁性颗粒的方法，其允许在所施加的宽频率和振幅范围内相对于其动态磁响应更有效地分级磁性颗粒 磁场，特别是与磁性粒子成像（MPI）有关。

公开(公告)号：US07777492B2

公开(公告)日：2010-08-17

申请号：US11908810

申请日：2006-03-31

申请人： Peter Vernickel ,  Bernhard Gleich ,  Kai-Michael Luedeke

发明人： Peter Vernickel ,  Bernhard Gleich ,  Kai-Michael Luedeke

IPC分类号： G01V3/00 ,  A61B5/05

CPC分类号： G01R33/3621 ,  A61N1/3718 ,  G01R33/287

摘要： The arrangement (10) is suited for transmitting an informative signal (S1), generated by suitable signal generator (1) at a first electrical site (7a) to a second electrical site (7b). The first electrical site (7a) is electrically connected to the second electrical site (7b) by means of a capacitively coupled transmission line (5a, 5b). In order to enable such capacitively coupled transmission line distributed or lumped capacitors (4a, 4b, 4c, 4d) can be used. The arrangement is connectable to an accessory device (6), which may comprise a spectrometer, a further signal generator, tuning means, etc. The further signal (S2) is generated by the accessory device (6) and transported via the capacitively coupled transmission line (5a, 5b) in a direction from the second electrical site (7b) to the first electrical site (7a). The further signal (S2) can be used for feeding an amplifier (2), or for carrying the signal (S1). The arrangement further relates to a magnetic resonance compatible device, a magnetic resonance imaging system and a method of sensing magnetic resonance energy.

摘要翻译： 该装置（10）适于将由合适的信号发生器（1）产生的信息信号（S1）在第一电站点（7a）传送到第二电气站点（7b）。 通过电容耦合传输线（5a，5b），第一电气部分（7a）与第二电气部位（7b）电连接。 为了能够使用这种电容耦合的传输线，可以使用分布或集中的电容器（4a，4b，4c，4d）。 该装置可连接到附件装置（6），附件装置（6）可以包括光谱仪，另外的信号发生器，调谐装置等。另外的信号（S2）由附件装置（6）产生并通过电容耦合传输 线路（5a，5b）沿着从第二电气部位（7b）到第一电气部位（7a）的方向。 另外的信号（S2）可以用于馈送放大器（2）或用于传送信号（S1）。 该装置还涉及磁共振兼容装置，磁共振成像系统和感测磁共振能量的方法。