知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

11 records (took 0.021 seconds)

    Fluorinated catharanthine derivatives, their preparation and their utilisation as Vinca dimeric alkaloid precursors
    3.
    发明授权
    Fluorinated catharanthine derivatives, their preparation and their utilisation as Vinca dimeric alkaloid precursors 失效
    氟化大黄素衍生物，其制备及其作为长春花二聚生物碱前体的利用

    公开(公告)号：US08101748B2

    公开(公告)日：2012-01-24

    申请号：US12442193

    申请日：2007-09-20

    Applicant: Lionel Moisan ,  Sébastien Comesse ,  Emerson Giovanelli ,  Bernard Rousseau ,  Eric Doris ,  Paul Hellier

    Inventor： Lionel Moisan ,  Sébastien Comesse ,  Emerson Giovanelli ,  Bernard Rousseau ,  Eric Doris ,  Paul Hellier

    IPC: C07D223/14

    CPC classification number: C07D471/22

    Abstract: The fluorinated derivatives of catharanthine according to the invention respond to the general formula I: in which: the dotted line expresses the possibility of the presence of a double bond when the substitution —X is absent or else a single bond when —X designates a substitution for a group: H, OR, NR′R″, SR, or a halogen atom with R, R′ and R″ designating independently of one another a hydrogen atom or a linear or branched alkyl group in C1 to C6, R1, R2 and R3 represent independently of one another an atom of hydrogen, of fluorine or a methylated group, on the condition nevertheless that at least one of the radicals R1 and R2 represents an atom of fluorine, and n=1 or 2.

    Abstract translation: 根据本发明的长春花碱的氟化衍生物响应通式I：其中：当-X不存在时，虚线表示存在双键的可能性，或者当-X表示取代时，表示存在双键的可能性 对于基团：H，OR，NR'R“，SR或具有R，R'和R”的卤素原子，彼此独立地指定C1至C6，R1，R2中的氢原子或直链或支链烷基 并且R 3彼此独立地表示氢原子，氟原子或甲基化基团，但是基团R 1和R 2中的至少一个表示氟原子，n = 1或2。

    FLUORINATED CATHARANTHINE DERIVATIVES, THEIR PREPARATION AND THEIR UTILISATION AS VINCA DIMERIC ALKALOID PRECURSORS
    5.
    发明申请
    FLUORINATED CATHARANTHINE DERIVATIVES, THEIR PREPARATION AND THEIR UTILISATION AS VINCA DIMERIC ALKALOID PRECURSORS 失效
    氟化胺类衍生物，其制备及其作为VINCA二聚体碱性前体的使用

    公开(公告)号：US20100093997A1

    公开(公告)日：2010-04-15

    申请号：US12442193

    申请日：2007-09-20

    Applicant: Lionel Moisan ,  Sébastien Comesse ,  Emerson Giovanelli ,  Bernard Rousseau ,  Eric Doris ,  Paul Hellier

    Inventor： Lionel Moisan ,  Sébastien Comesse ,  Emerson Giovanelli ,  Bernard Rousseau ,  Eric Doris ,  Paul Hellier

    IPC: C07D487/22

    CPC classification number: C07D471/22

    Abstract: The fluorinated derivatives of catharanthine according to the invention respond to the general formula I: in which: the dotted line expresses the possibility of the presence of a double bond when the substitution —X is absent or else a single bond when —X designates a substitution for a group: H, OR, NR′R″, SR, or a halogen atom with R, R′ and R″ designating independently of one another a hydrogen atom or a linear or branched alkyl group in C1 to C6, R1, R2 and R3 represent independently of one another an atom of hydrogen, of fluorine or a methylated group, on the condition nevertheless that at least one of the radicals R1 and R2 represents an atom of fluorine, and n=1 or 2.

    Abstract translation: 根据本发明的长春花碱的氟化衍生物响应通式I：其中：当-X不存在时，虚线表示存在双键的可能性，或者当-X表示取代时，表示存在双键的可能性 对于基团：H，OR，NR'R“，SR或具有R，R'和R”的卤素原子，彼此独立地指定C1至C6，R1，R2中的氢原子或直链或支链烷基 并且R 3彼此独立地表示氢原子，氟原子或甲基化基团，但是基团R 1和R 2中的至少一个表示氟原子，n = 1或2。

Patent Agency Ranking