公开(公告)号：US08834913B2

公开(公告)日：2014-09-16

申请号：US12648106

申请日：2009-12-28

申请人： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

发明人： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

IPC分类号： A61F2/00 ,  A61K31/727

CPC分类号： A61L31/10 ,  A61K31/727 ,  A61L31/16 ,  A61L2300/42 ,  A61L2400/18

摘要： A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

摘要翻译： 一种具有氧化表面的基底和与氧化表面共价结合的硅烷衍生物涂层的医用植入装置。 生物活性剂与硅烷衍生物涂层共价键合。 一种可植入支架装置，其包括具有氧化表面的支架芯，其具有与其共价键合的硅烷衍生物层。 包含聚乙二醇（PEG）的间隔层与硅烷衍生物层共价键合，蛋白质与PEG共价键合。 一种制造医疗植入装置的方法，包括提供具有表面的基底，氧化表面并与衍生的硅烷反应以形成共价键合到该表面的硅烷涂层。 然后将生物活性剂共价键合到硅烷涂层。 在特定情况下，生物吸收性聚合物和/或药剂的附加涂层沉积在生物活性剂上。

公开(公告)号：US20150024116A1

公开(公告)日：2015-01-22

申请号：US14122862

申请日：2012-05-30

申请人： Dean W. Matson ,  Clement R. Yonker ,  John L. Fulton ,  George S. Deverman ,  Barbara J. Tarasevich ,  Wendy J. Shaw ,  Leonard S. Fifield ,  Krys Wallace ,  C. Douglas Taylor ,  James B. McClain

发明人： Dean W. Matson ,  Clement R. Yonker ,  John L. Fulton ,  George S. Deverman ,  Barbara J. Tarasevich ,  Wendy J. Shaw ,  Leonard S. Fifield ,  Krys Wallace ,  C. Douglas Taylor ,  James B. McClain

IPC分类号： B05D1/06 ,  A61L31/10 ,  A61L29/08 ,  B05D1/04

摘要： A system and method are disclosed for coating surfaces of expandable medical devices with composite coatings. Coatings are composed of various materials including, e.g., polymers and drugs. Transfer of the coatings within a patient or other host forms a drug-eluting coating that delivers time-released drugs over time for treatment of a medical condition.

摘要翻译： 公开了用于涂覆具有复合涂层的可扩张医疗装置的表面的系统和方法。 涂料由各种材料组成，包括例如聚合物和药物。 患者或其他宿主内的涂层转移形成药物洗脱涂层，随时间推移释放药物以治疗医疗状况。

公开(公告)号：US5759708A

公开(公告)日：1998-06-02

申请号：US318540

申请日：1994-10-05

申请人： Barbara J. Tarasevich ,  Peter C. Rieke

发明人： Barbara J. Tarasevich ,  Peter C. Rieke

IPC分类号： C23C8/28 ,  B05D3/10 ,  C08J7/06 ,  C23C18/12 ,  B32B11/00

CPC分类号： C08J7/06 ,  B05D3/10 ,  C23C18/04 ,  C23C18/1208

摘要： A method is provided for producing a thin film product, comprising a first step in which an underlying substrate of a first material is provided. The underlying substrate includes a plurality of unmodified sites. The underlying substrate is then chemically modified wherein a plurality of organic functional groups are attached to a plurality of the unmodified sites. The arrangement and type of the functional group used can be selected for the purpose of controlling particular properties of the second material deposited. A thin film layer of at least one second material is then deposited onto the chemically modified underlying substrate. This can be accomplished by connecting the thin film to the underlying substrate by binding the thin film to the functional groups.

摘要翻译： 提供了一种用于制造薄膜产品的方法，包括第一步骤，其中提供第一材料的下面的基底。 底层基底包括多个未改性位点。 然后将底层基底化学修饰，其中多个有机官能团连接到多个未改性位点。 可以选择所使用的官能团的布置和类型，以便控制沉积的第二材料的特定性质。 然后将至少一种第二材料的薄膜层沉积到化学修饰的底层基底上。 这可以通过将薄膜结合到官能团将薄膜连接到下面的基底来实现。

公开(公告)号：US10464100B2

公开(公告)日：2019-11-05

申请号：US14122862

申请日：2012-05-30

申请人： Dean W. Matson ,  Clement R. Yonker ,  John L. Fulton ,  George S. Deverman ,  Barbara J. Tarasevich ,  Wendy J. Shaw ,  Leonard S. Fifield ,  Krys Wallace ,  C. Douglas Taylor ,  James B. McClain

发明人： Dean W. Matson ,  Clement R. Yonker ,  John L. Fulton ,  George S. Deverman ,  Barbara J. Tarasevich ,  Wendy J. Shaw ,  Leonard S. Fifield ,  Krys Wallace ,  C. Douglas Taylor ,  James B. McClain

IPC分类号： B05D1/06 ,  B05D1/04 ,  A61L29/08 ,  A61L31/10 ,  A61F2/82 ,  A61K9/70 ,  A61M25/10

摘要： A system and method are disclosed for coating surfaces of expandable medical devices with composite coatings. Coatings are composed of various materials including, e.g., polymers and drugs. Transfer of the coatings within a patient or other host forms a drug-eluting coating that delivers time-released drugs over time for treatment of a medical condition.

公开(公告)号：US20140249102A1

公开(公告)日：2014-09-04

申请号：US13173262

申请日：2011-06-30

申请人： Tatiana G. Levitskaia ,  Karla D. Thrall ,  James M. Peterson ,  Glen E. Fryxell ,  Charles A. Timchalk ,  Barbara J. Tarasevich

发明人： Tatiana G. Levitskaia ,  Karla D. Thrall ,  James M. Peterson ,  Glen E. Fryxell ,  Charles A. Timchalk ,  Barbara J. Tarasevich

IPC分类号： A61K31/722 ,  A61K9/00 ,  A61K45/06 ,  A61K31/734

CPC分类号： A61K31/722 ,  A61K9/0014 ,  A61K31/734 ,  A61K45/06 ,  A61L15/28 ,  A61L15/42 ,  A61L15/44 ,  A61L24/0021 ,  A61L26/0023 ,  A61L26/0066 ,  G21F9/002 ,  G21F9/28

摘要： A topical applicator composition and process are described that decorporate radionuclides from radiologically-contaminated dermal surfaces and that further promote healing. The topical applicator includes a decorporation agent mixed with a plasticizing agent that forms a covering when applied to the dermal surface that decorporates radionuclides and minimizes their systemic migration. The topical applicator formulations can be delivered in conjunction with bandages and other application dressings.

摘要翻译： 描述了一种局部施用组合物和方法，其将放射性核素从放射性污染的皮肤表面分解，并进一步促进愈合。 局部施用器包括与增塑剂混合的脱落剂，当增塑剂施用于真皮表面并形成放射性核素并使其全身迁移最小化时形成覆盖物。 局部给药制剂可以与绷带和其它应用敷料一起递送。

公开(公告)号：US20110159069A1

公开(公告)日：2011-06-30

申请号：US12648106

申请日：2009-12-28

申请人： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

发明人： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

IPC分类号： A61F2/02 ,  A61K31/727 ,  A61K38/16 ,  A61F11/00 ,  A61P43/00

CPC分类号： A61L31/10 ,  A61K31/727 ,  A61L31/16 ,  A61L2300/42 ,  A61L2400/18

摘要： A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

摘要翻译： 一种具有氧化表面的基底和与氧化表面共价结合的硅烷衍生物涂层的医用植入装置。 生物活性剂与硅烷衍生物涂层共价键合。 一种可植入支架装置，其包括具有氧化表面的支架芯，其具有与其共价键合的硅烷衍生物层。 包含聚乙二醇（PEG）的间隔层与硅烷衍生物层共价键合，蛋白质与PEG共价键合。 一种制造医疗植入装置的方法，包括提供具有表面的基底，氧化表面并与衍生的硅烷反应以形成共价键合到该表面的硅烷涂层。 然后将生物活性剂共价键合到硅烷涂层。 在特定情况下，生物吸收性聚合物和/或药剂的附加涂层沉积在生物活性剂上。