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    OPTICAL DETERMINATION OF GLUCOSE UTILIZING BORONIC ACID ADDUCTS
    1.
    发明申请
    OPTICAL DETERMINATION OF GLUCOSE UTILIZING BORONIC ACID ADDUCTS 有权
    使用硼酸添加剂的葡萄糖的光学测定

    公开(公告)号：US20090149656A1

    公开(公告)日：2009-06-11

    申请号：US12189089

    申请日：2008-08-08

    Applicant: Bakthan Singaram ,  Ritchie A. Wessling

    Inventor： Bakthan Singaram ,  Ritchie A. Wessling

    IPC: C07D401/00 ,  C07C69/52

    CPC classification number: A61K49/0019 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  B82Y30/00 ,  C07D213/82 ,  C07F5/025 ,  C09K9/02 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  G01N33/542 ,  G01N33/543 ,  G01N33/582 ,  G01N33/66 ,  Y10T436/144444

    Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

    Abstract translation: 本发明涉及一种改进的光学方法和光学感测装置，用于确定水性介质中体外和/或体内多羟基取代的有机分子的水平。 检测范围在约400和800nm之间。 特别地，在哺乳动物中实施感官设计以确定糖水平。 具体地说，在糖如果糖或葡萄糖的存在下，将染料与共轭含氮杂环芳族硼酸取代的双鎓化合物组合。 紫罗兰是优选的芳族共轭含氮硼酸取代的化合物。 该方法对于测定人的糖含量是有用的。

    SYNTHESIS OF BORONIC ESTERS AND BORONIC ACIDS USING GRIGNARD REAGENTS
    3.
    发明申请
    SYNTHESIS OF BORONIC ESTERS AND BORONIC ACIDS USING GRIGNARD REAGENTS 有权
    使用格兰杰试剂合成硼酸和硼酸

    公开(公告)号：US20150119580A1

    公开(公告)日：2015-04-30

    申请号：US14234382

    申请日：2012-07-20

    Applicant: Jacob W. Clary ,  Bakthan Singaram

    Inventor： Jacob W. Clary ,  Bakthan Singaram

    IPC: C07F5/04 ,  C07F5/02

    CPC classification number: C07F5/04 ,  C07F5/025

    Abstract: Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg0. When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.

    Abstract translation: 通过Grignard试剂与含硼底物的反应，在环境温度下在醚溶剂中合成硼酸酯和硼酸。 含硼底物可以是硼酸酯，例如频哪醇硼烷，新戊基乙二醇硼烷，或二异丙基氨基硼烷等二烷基氨基硼烷化合物。 格氏试剂可以由烷基，烯基，芳基，芳基烷基，杂芳基，乙烯基或烯丙基卤化合物和MgO预先形成或生成。 当含硼底物是硼酸酯时，反应通常在室温下进行，而不在约1至3小时内加入碱以形成硼酸酯化合物。 当含硼底物是二烷基氨基硼烷化合物时，反应通常在0℃下在约1小时内完成以形成硼酸化合物。

    Optical determination of glucose utilizing boronic acid adducts
    4.
    发明授权
    Optical determination of glucose utilizing boronic acid adducts 有权
    使用硼酸加合物光学测定葡萄糖

    公开(公告)号：US07968714B2

    公开(公告)日：2011-06-28

    申请号：US12189089

    申请日：2008-08-08

    Applicant: Bakthan Singaram ,  Ritchie A. Wessling

    Inventor： Bakthan Singaram ,  Ritchie A. Wessling

    IPC: C07F5/02 ,  C07D401/04

    CPC classification number: A61K49/0019 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  B82Y30/00 ,  C07D213/82 ,  C07F5/025 ,  C09K9/02 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  G01N33/542 ,  G01N33/543 ,  G01N33/582 ,  G01N33/66 ,  Y10T436/144444

    Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

    Abstract translation: 本发明涉及一种改进的光学方法和光学感测装置，用于确定水性介质中体外和/或体内多羟基取代的有机分子的水平。 检测范围在约400和800nm之间。 特别地，在哺乳动物中实施感官设计以确定糖水平。 具体地说，在糖如果糖或葡萄糖的存在下，将染料与共轭含氮杂环芳族硼酸取代的双鎓化合物组合。 紫罗兰是优选的芳族共轭含氮硼酸取代的化合物。 该方法对于测定人的糖含量是有用的。

    Synthesis of lithium aminoborohydrides and reactions thereof
    6.
    发明授权
    Synthesis of lithium aminoborohydrides and reactions thereof 失效
    氨基硼氢化锂的合成及其反应

    公开(公告)号：US5466798A

    公开(公告)日：1995-11-14

    申请号：US138612

    申请日：1993-10-15

    Applicant: Bakthan Singaram ,  Gary B. Fisher ,  Joseph C. Fuller ,  John Harrison ,  Christian T. Goralski

    Inventor： Bakthan Singaram ,  Gary B. Fisher ,  Joseph C. Fuller ,  John Harrison ,  Christian T. Goralski

    IPC: C07C213/00 ,  C07C215/08 ,  C07D295/084 ,  C07D295/088 ,  C07D295/096 ,  C07D223/02 ,  C07D207/00 ,  C07F5/02

    CPC classification number: C07D295/096 ,  C07C213/00 ,  C07C215/08 ,  C07D295/084 ,  C07D295/088 ,  C07D295/092

    Abstract: The present invention relates to novel, powerful reducing agents, lithium aminoborohydrides which are prepared by addition of BH.sub.3 .cndot.THF to the corresponding dialkylamine at 25.degree. C. to give the intermediate amineborane complex. Subsequent deprotonation by strong base, e.g. n-BuLi, yields the aminoborohydride quantitatively. Lithium aminoborohydrides are powerful reducing agents, comparable in strength to lithium aluminum hydride. The activity is determined by the dialkylamine. Lithium pyrrolidinoborohydride has unique activity and selectivity in its reducing properties. Esters, lactones and anhydrides are reduced cleanly at 25.degree. C. to give the corresponding alcohols, while carboxylic acids are not reduced. Test reductions show that lithium pyrrolidinoborohydride is also capable of reducing a wide range of functional groups including amides, epoxides, oximes, nitriles and halides.

    Abstract translation: 本发明涉及通过在25℃下向相应的二烷基胺中加入BH3.THF而制得的新的强大的还原剂氨基硼酸锂，得到中间体胺硼烷络合物。 随后通过强碱去质子化，例如 n-BuLi，定量产生氨基硼氢化钠。 氨基硼氢化锂是强大的还原剂，其强度与氢化铝锂相当。 活性由二烷基胺决定。 吡咯烷基硼氢化锂在还原性能方面具有独特的活性和选择性。 酯，内酯和酸酐在25℃下干净地还原，得到相应的醇，而羧酸不被还原。 测试减少表明，吡咯烷基硼氢化锂还能够减少宽范围的官能团，包括酰胺，环氧化物，肟，腈和卤化物。

    Synthesis of boronic esters and boronic acids using grignard reagents
    7.
    发明授权
    Synthesis of boronic esters and boronic acids using grignard reagents 有权
    使用格氏试剂合成硼酸酯和硼酸

    公开(公告)号：US09243004B2

    公开(公告)日：2016-01-26

    申请号：US14234382

    申请日：2012-07-20

    Applicant: Jacob W. Clary ,  Bakthan Singaram

    Inventor： Jacob W. Clary ,  Bakthan Singaram

    IPC: C07F5/04 ,  C07F5/02

    CPC classification number: C07F5/04 ,  C07F5/025

    Abstract: Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg0. When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.

    Abstract translation: 通过Grignard试剂与含硼底物的反应，在环境温度下在醚溶剂中合成硼酸酯和硼酸。 含硼底物可以是硼酸酯，例如频哪醇硼烷，新戊基乙二醇硼烷，或二异丙基氨基硼烷等二烷基氨基硼烷化合物。 格氏试剂可以由烷基，烯基，芳基，芳基烷基，杂芳基，乙烯基或烯丙基卤化合物和MgO预先形成或生成。 当含硼底物是硼酸酯时，反应通常在室温下进行，而不在约1至3小时内加入碱以形成硼酸酯化合物。 当含硼底物是二烷基氨基硼烷化合物时，反应通常在0℃下在约1小时内完成以形成硼酸化合物。

    Polyhydroxyl-substituted organic molecule sensing method and device
    10.
    发明授权
    Polyhydroxyl-substituted organic molecule sensing method and device 有权
    多羟基取代有机分子感应方法及装置

    公开(公告)号：US06653141B2

    公开(公告)日：2003-11-25

    申请号：US09731325

    申请日：2000-12-05

    Applicant: Bakthan Singaram ,  Ritchie A. Wessling

    Inventor： Bakthan Singaram ,  Ritchie A. Wessling

    IPC: G01N2164

    CPC classification number: G01N21/6408 ,  Y10T436/144444

    Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro in aqueous or organic media. Specifically, a dye is combined with an conjugated nitrogen-containing aromatic heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen containing boronic acid substituted compounds. The method is useful to determine sugar levels in fermentation and process streams.

    Abstract translation: 本发明涉及用于在水性或有机介质中体外测定多羟基取代的有机分子水平的改进​​的光学方法和光学感测装置。 具体地说，在糖如果糖或葡萄糖的存在下，将染料与共轭含氮芳族杂环芳族硼酸取代的双鎓化合物组合。 紫罗兰是优选的含芳族共轭氮的硼酸取代的化合物。 该方法可用于测定发酵和过程流中的糖含量。

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