公开(公告)号：US20070270484A1

公开(公告)日：2007-11-22

申请号：US10573275

申请日：2003-09-25

申请人： Biswajit Das ,  Mohammad Salman ,  Sachin Shelke ,  Atul Hajare ,  Sanjay Talukdar ,  Sujata Rathy ,  Arani Pal ,  Ashok Rattan

发明人： Biswajit Das ,  Mohammad Salman ,  Sachin Shelke ,  Atul Hajare ,  Sanjay Talukdar ,  Sujata Rathy ,  Arani Pal ,  Ashok Rattan

IPC分类号： A61K31/7048 ,  A61P31/04 ,  C07H17/08

CPC分类号： A61K31/7048 ,  Y02A50/473

摘要： This invention generally relates to macrolides, more particularly, the invention relates to 3-N-substituted-3-O-substituted erythronolide A derivatives, which are antibacterial agents effective against gram positive or gram negative bacteria and atypical pathogens. The compounds of this invention are more particularly effective against Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Haemophilus influenzae. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating bacterial infection.

摘要翻译： 本发明一般涉及大环内酯类，更具体地说，本发明涉及3-N-取代-3-O-取代的红景天苷A衍生物，它们是对革兰氏阳性或革兰氏阴性细菌和非典型病原体有效的抗菌剂。 本发明的化合物对金黄色葡萄球菌，肺炎链球菌，粪肠球菌，大肠杆菌，铜绿假单胞菌，流感嗜血杆菌更为特别有效。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和治疗细菌感染的方法。