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公开(公告)号：US08449465B2
公开(公告)日：2013-05-28
申请号：US11580342
申请日：2006-10-14
IPC分类号： A61B8/00
CPC分类号： A61B8/0891 , A61B5/02007 , A61B5/7203 , A61B5/726 , A61B8/0833 , A61B8/12 , A61B8/4461 , A61B8/4488 , A61B8/461 , A61B8/467 , A61B8/52 , A61B8/5238 , G01S7/5205 , G01S7/52087 , G01S15/8977 , G06F19/00
摘要： A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter and/or substantially synchronizing the acquisition of blood-vessel data to an identifiable portion of heartbeat data. In one embodiment, a computing device and catheter acquire RF backscattered data from a vascular structure. The backscattered ultrasound data is then used to estimate at least one transfer function. The transfer function(s) can then be used to calculate response data for the vascular tissue. Another embodiment includes an IVUS console connected to a catheter and a computing device that acquires RF backscattered data from a vascular structure. Based on the backscattered data, the computing device estimates the catheter's transfer function and to calculate response data for the vascular tissue. The response data and histology data are then used to characterize at least a portion of the vascular tissue.
摘要翻译： 提供了一种用于使用从血管组织反向散射的超声数据来估计导管的传递功能和/或使血管数据的获取基本上同步到心跳数据的可识别部分的系统和方法。 在一个实施例中，计算装置和导管从血管结构获取RF背散射数据。 然后使用后向散射超声数据来估计至少一个传递函数。 然后可以使用传递函数来计算血管组织的反应数据。 另一个实施例包括连接到导管的IVUS控制台和从血管结构获取RF背散射数据的计算设备。 基于背散射数据，计算装置估计导管的传递函数并计算血管组织的反应数据。 然后使用响应数据和组织学数据来表征血管组织的至少一部分。
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公开(公告)号：US08425423B2
公开(公告)日：2013-04-23
申请号：US12875390
申请日：2010-09-03
CPC分类号： A61B8/5207 , A61B5/02007 , A61B8/085 , A61B8/12 , A61B8/4488 , A61B8/461 , G01S7/52036 , G01S15/8956
摘要： A system and method are disclosed that facilitate generating visual representations of characterized tissue based upon ultrasound echo information obtained from a portion of an imaged body. The system includes a first filter having a first filter band that is applied to a near range portion of the ultrasound echo information to render near range filtered echo information. A second filter, having a second filter band that covers a frequency range of the first filter band, is applied to a far range portion of the ultrasound echo information to render far range filtered echo information. The system furthermore includes a set of characterization criteria that are applied to the near and far range filtered echo information. The characterized near and far range image data are thereafter combined into a single tissue-characterization image.
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公开(公告)号：US20130028497A1
公开(公告)日：2013-01-31
申请号：US13563299
申请日：2012-07-31
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , A61B5/02007 , A61B8/12 , G06T7/12 , G06T2207/10132 , G06T2207/20101 , G06T2207/30101
摘要： A system and method are provided for using a first vascular image, or more particularly a plurality of control points located thereon, to identify a border on a second vascular image. Embodiments of the present invention operate in accordance with an intra-vascular ultrasound (IVUS) device and a computing device electrically connected thereto. In one embodiment, the computing device includes a plurality of applications operating thereon that are used to (I) identify a border and control points on a first IVUS image (i.e., any IVUS image), (ii) extrapolate the control points to a second IVUS image (i.e., another IVUS image), (iii) identify a border on the second IVUS image, and (iv) adjust the border on the second IVUS image in accordance with at least one factor.
摘要翻译： 提供了一种系统和方法，用于使用位于其上的第一血管图像，或更具体地多个控制点来识别第二血管图像上的边界。 本发明的实施例根据血管内超声（IVUS）装置和与其电连接的计算装置进行操作。 在一个实施例中，计算设备包括多个在其上操作的应用，其用于（I）识别第一IVUS图像（即，任何IVUS图像）上的边界和控制点，（ii）将控制点外推到第二IVUS IVUS图像（即另一IVUS图像），（iii）识别第二IVUS图像上的边界，以及（iv）根据至少一个因素调整第二IVUS图像上的边界。
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4.发明授权公开(公告)号：US07627156B2
公开(公告)日：2009-12-01
申请号：US11689963
申请日：2007-03-22
CPC分类号： A61B8/12 , A61B5/02007 , A61B5/7264 , A61B8/0833 , G06F19/00 , G06T7/0012 , G06T2207/30101
摘要： A system and method are disclosed for automatically classifying plaque lesions. A plaque classification application applies a plaque classification criterion to at least one graphical image, comprising a map of spectrally-analyzed characterized tissue of a vessel cross-section, to render an overall plaque classification for the slice or set of slices, covering a 3D volume. The plaque classification is based upon the amount and location of each characterized tissue type (e.g., necrotic core—NC). In an exemplary embodiment the set of potential plaque classifications, not to be confused with characterized tissue types—from which the plaque classifications are derived—include, for example: adaptive intimal thickening (AIT), pathological intimal thickening (PIT), fibroatheroma (FA), thin-cap fibroatheroma (TCFA), and fibro-calcific (FC).
摘要翻译： 公开了用于自动分类斑块损伤的系统和方法。 斑块分类应用将斑块分类标准应用于至少一个图形图像，其包括血管横截面的光谱分析的特征性组织的图，以呈现切片或切片组的整体斑块分类，覆盖3D体积 。 斑块分类基于每个特征性组织类型（例如，坏死核 - NC）的量和位置。 在一个示例性的实施方案中，不会与斑块分类来源的特征性组织类型混淆的一组潜在斑块分类包括例如：适应性内膜增厚（AIT），病理性内膜增厚（PIT），纤维变性（FA） ），薄盖纤维性肝硬化（TCFA）和纤维钙化（FC）。
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公开(公告)号：US20080287795A1
公开(公告)日：2008-11-20
申请号：US12102661
申请日：2008-04-14
IPC分类号： A61B8/12
CPC分类号： G06T7/0012 , A61B5/02007 , A61B8/12 , G06T7/12 , G06T2207/10132 , G06T2207/20101 , G06T2207/30101
摘要： A system and method is provided for using a first vascular image, or more particularly a plurality of control points located thereon, to identify a border on a second vascular image. Embodiments of the present invention operate in accordance with an intra-vascular ultrasound (IVUS) device and a computing device electrically connected thereto. Specifically, in one embodiment of the present invention, an-IVUS console is electrically connected to a computing device and adapted to acquire IVUS data. The IVUS data (or multiple sets thereof) is then provided to (or acquired by) the computing device. In one embodiment of the present invention, the computing device includes a plurality of applications operating thereon—i.e., a border-detection application, an extrapolation application, and an active-contour application. These applications are used to (i) identify a border and control points on a first IVUS image (i.e., any IVUS image), (ii) extrapolate the control points to a second IVUS image (i.e., another IVUS image), (iii) identify a border on the second IVUS image, and (iv) adjust the border on the second IVUS image in accordance with at least one factor. In one embodiment of the present invention, the at least one factor is selected from a group consisting of gradient factor, continuity factor, and curvature factor.
摘要翻译： 提供了一种系统和方法，用于使用位于其上的第一血管图像，或更具体地多个控制点来识别第二血管图像上的边界。 本发明的实施例根据血管内超声（IVUS）装置和与其电连接的计算装置进行操作。 具体来说，在本发明的一个实施例中，-IVUS控制台电连接到计算设备并适于获取IVUS数据。 然后将IVUS数据（或其多组）提供给计算设备（或由其获取）。 在本发明的一个实施例中，计算设备包括在其上操作的多个应用，即边界检测应用，外推应用和主动轮廓应用。 这些应用用于（i）识别第一IVUS图像（即，任何IVUS图像）上的边界和控制点，（ii）将控制点外推到第二IVUS图像（即另一IVUS图像），（iii） 识别第二IVUS图像上的边界，以及（iv）根据至少一个因素调整第二IVUS图像上的边界。 在本发明的一个实施例中，至少一个因素选自由梯度因子，连续性因子和曲率因子组成的组。
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公开(公告)号：US20070201736A1
公开(公告)日：2007-08-30
申请号：US11786599
申请日：2007-04-12
申请人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
发明人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
IPC分类号： G06K9/00
CPC分类号： A61B8/12 , A61B5/02007 , A61B8/0858
摘要： The present invention uses a radio frequency (RF) signal backscattered from vascular tissue to identify a border on a vascular image. Embodiments of the invention operate in accordance with a data gathering device connected to a computing device and a transducer via a catheter. The transducer is used to gather RF data backscattered from vascular tissue. The RF data is provided to the computing device via the data-gathering device. In one embodiment of the present invention, the computing device includes (i) a data storage device for storing tissue types and related parameters and (ii) an application. The application is used to convert the RF data into the frequency domain and to identify associated parameters. The parameters are compared to the parameters stored in the data storage device to identify the corresponding tissue type. This information is used, possibly with other border-related information, to determine a border on a vascular image.
摘要翻译： 本发明使用从血管组织反向散射的射频（RF）信号来识别血管图像上的边界。 本发明的实施例根据经由导管连接到计算设备和换能器的数据采集设备进行操作。 传感器用于收集从血管组织反向散射的RF数据。 RF数据经由数据收集装置提供给计算装置。 在本发明的一个实施例中，计算设备包括（i）用于存储组织类型和相关参数的数据存储设备，以及（ii）应用。 该应用程序用于将RF数据转换为频域并识别相关参数。 将参数与存储在数据存储设备中的参数进行比较，以识别相应的组织类型。 该信息可能与其他与边界有关的信息用于确定血管图像上的边界。
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公开(公告)号：US20060241487A1
公开(公告)日：2006-10-26
申请号：US11445782
申请日：2006-06-01
申请人： Anuja Nair , D. Vince , Jon Klingonamith , Barry Kuban
发明人： Anuja Nair , D. Vince , Jon Klingonamith , Barry Kuban
IPC分类号： A61B8/14
CPC分类号： A61B8/12 , A61B5/02007 , A61B5/7257 , A61B5/726 , A61B8/0833 , G06T7/0012 , G06T2207/30101
摘要： A system and method is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, in one embodiment of the present invention, an ultrasonic device is used to acquire RF backscattered data (i.e., IVUS data) from a blood vessel. The IVUS data is then transmitted to a computing device and used to create an IVUS image. The blood vessel is then cross-sectioned and used to identify its tissue type and to create a corresponding image (i.e., histology image). A region of interest (ROI), preferably corresponding to the identified tissue type, is then identified on the histology image. The computing device, or more particularly, a characterization application operating thereon, is then adapted to identify a corresponding region on the IVUS image. To accurately match the ROI, however, it may be necessary to warp or morph the histology image to substantially fit the contour of the IVUS image. After the corresponding region is identified, the IVUS data that corresponds to this region is identified. Signal processing is then performed and at least one parameter is identified. The identified parameter and the tissue type (e.g., characterization data) is stored in a database. In another embodiment of the present invention, the characterization application is adapted to receive IVUS data, determine parameters related thereto (either directly or indirectly), and use the parameters stored in the database to identify a tissue type or a characterization thereof.
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公开(公告)号：US20050154315A1
公开(公告)日：2005-07-14
申请号：US10758477
申请日：2004-01-14
申请人： Anuja Nair , D. Vince , Jon Klingensmith , Barry Kuban
发明人： Anuja Nair , D. Vince , Jon Klingensmith , Barry Kuban
CPC分类号： A61B5/02007 , A61B5/726 , A61B8/12
摘要： A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter (including components attached thereto—e.g., IVUS console, transducer, etc.). Specifically, in accordance with a first embodiment of the present invention, a computing device is electrically connected to a catheter and used to acquire RF backscattered data from a vascular structure (e.g., a blood vessel, etc.). The backscattered ultrasound data is then used, together with an algorithm, to estimate the transfer function. The transfer function can then be used (at least in a preferred embodiment) to calculate response data for the vascular tissue (i.e., the tissue component of the backscattered ultrasound data). In a second embodiment of the present invention, an IVUS console is electrically connected to a catheter and a computing device and is used to acquire RF backscattered data from a vascular structure. The backscattered data is then transmitted to the computing device, where it is used to estimate the catheter's transfer function and to calculate response data for the vascular tissue. The response data and histology data are then used to characterize at least a portion of the vascular tissue (e.g., identify tissue type, etc.).
摘要翻译： 提供了一种系统和方法，用于使用从血管组织反向散射的超声数据来估计导管（包括与其连接的部件，例如，IVUS控制台，换能器等）的传递功能。 具体地，根据本发明的第一实施例，计算设备电连接到导管并用于从血管结构（例如，血管等）获取RF背散射数据。 然后将后向散射的超声数据与算法一起用于估计传递函数。 然后可以使用传递函数（至少在一个优选实施例中）来计算血管组织的反应数据（即背散射超声数据的组织分量）。 在本发明的第二实施例中，IVUS控制台电连接到导管和计算设备，并用于从血管结构获取RF背散射数据。 然后将背散射数据传输到计算设备，其中其用于估计导管的传递函数并计算血管组织的反应数据。 然后使用响应数据和组织学数据来表征血管组织的至少一部分（例如，识别组织类型等）。
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公开(公告)号：US20220139561A1
公开(公告)日：2022-05-05
申请号：US12890633
申请日：2010-09-25
摘要： Using a patient's physiological parameters ascertained using standard intravascular ultrasound (IVUS) in combination with virtual histology (VH), these physiological parameters are evaluated to predict whether the patient's physiology has an increased risk of producing a Clinical Event or a Silent Clinical Event. In one embodiment the following three physiological parameters: the Plaque Burden; the Minimum Lumen Area; and whether a VH-TCFA or multiple VH-TCFAs are present are compared to target values and ranges. A concurrence of the values for the physiological parameters falling within the target ranges indicates that a patient's physiology has an increased risk of producing a Clinical Event or a Silent Clinical Event, respectively. In other embodiments, combinations of any two of the three physiological parameters listed above are compared to target values and ranges. A concurrence of the values for two of the physiological parameters falling within the target ranges indicates that a patient's physiology has an increased risk of producing a Clinical Event. In still other embodiments, any of the three physiological parameters listed above are compared to target values and ranges. Any of the values of the physiological parameters falling within the target ranges indicates that a patient's physiology has an increased risk of producing a Clinical Event.
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公开(公告)号：US08233718B2
公开(公告)日：2012-07-31
申请号：US13155196
申请日：2011-06-07
CPC分类号： G06T7/0012 , A61B5/02007 , A61B8/12 , G06T7/12 , G06T2207/10132 , G06T2207/20101 , G06T2207/30101
摘要： A system and method is provided for using a first vascular image, or more particularly a plurality of control points located thereon, to identify a border on a second vascular image. Embodiments of the present invention operate in accordance with an intra-vascular ultrasound (IVUS) device and a computing device electrically connected thereto. Specifically, in one embodiment of the present invention, an IVUS console is electrically connected to a computing device and adapted to acquire IVUS data. The IVUS data (or multiple sets thereof) is then provided to (or acquired by) the computing device. In one embodiment of the present invention, the computing device includes a plurality of applications operating thereon—i.e., a border-detection application, an extrapolation application, and an active-contour application. These applications are used to (i) identify a border and control points on a first IVUS image (i.e., any IVUS image), (ii) extrapolate the control points to a second IVUS image (i.e., another IVUS image), (iii) identify a border on the second IVUS image, and (iv) adjust the border on the second IVUS image in accordance with at least one factor. In one embodiment of the present invention, the at least one factor is selected from a group consisting of gradient factor, continuity factor, and curvature factor.
摘要翻译： 提供了一种系统和方法，用于使用位于其上的第一血管图像，或更具体地多个控制点来识别第二血管图像上的边界。 本发明的实施例根据血管内超声（IVUS）装置和与其电连接的计算装置进行操作。 具体地，在本发明的一个实施例中，IVUS控制台电连接到计算设备并适于获取IVUS数据。 然后将IVUS数据（或其多组）提供给计算设备（或由其获取）。 在本发明的一个实施例中，计算设备包括在其上操作的多个应用，即边界检测应用，外推应用和主动轮廓应用。 这些应用用于（i）识别第一IVUS图像（即，任何IVUS图像）上的边界和控制点，（ii）将控制点外推到第二IVUS图像（即另一IVUS图像），（iii） 识别第二IVUS图像上的边界，以及（iv）根据至少一个因素调整第二IVUS图像上的边界。 在本发明的一个实施例中，至少一个因素选自由梯度因子，连续性因子和曲率因子组成的组。
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