公开(公告)号：US20060276392A1

公开(公告)日：2006-12-07

申请号：US11327952

申请日：2006-01-09

申请人： Ma Mira ,  Ma Mercedes Hernandez ,  Ana Tebar ,  Gregorio Ballester ,  Luis Gutierrez ,  Teresa Castello ,  Enrique Paya ,  Rosa Cases ,  Antonio Montiel ,  Salvador Bover

发明人： Ma Mira ,  Ma Mercedes Hernandez ,  Ana Tebar ,  Gregorio Ballester ,  Luis Gutierrez ,  Teresa Castello ,  Enrique Paya ,  Rosa Cases ,  Antonio Montiel ,  Salvador Bover

IPC分类号： A61K38/16 ,  A61K38/10 ,  A61K38/08

CPC分类号： C07K14/47 ,  A61K8/64 ,  A61K38/00 ,  A61K48/00 ,  A61Q19/08 ,  C07K14/705

摘要： The peptide has a sequence of 3 to 30 adjacent aminoacids from the amino end of protein SNAP-25 and is useful as neuronal exocytosis inhibitor. The cosmetic and pharmaceutical compositions contain said peptide and optionally one or more peptides from the carboxyl end of SNAP-25. Said compositions are suitable for the treatment of facial wrinkles and asymmetry and pathological neuronal exocytosis-mediated pathological disorders and alterations.

摘要翻译： 该肽具有从蛋白SNAP-25的氨基末端3〜30个相邻氨基酸的序列，可用作神经元胞吐作用抑制剂。 化妆品和药物组合物含有所述肽和任选的一种或多种来自SNAP-25羧基末端的肽。 所述组合物适用于治疗面部皱纹和不对称和病理性神经元胞吐作用介导的病理学障碍和改变。

公开(公告)号：US20050130907A1

公开(公告)日：2005-06-16

申请号：US10515459

申请日：2003-05-16

申请人： Antonio Montiel ,  Asia Carvajal ,  Carolina Martinez ,  Carlos Martinez ,  Wim Nest ,  Cristina Serraima

发明人： Antonio Montiel ,  Asia Carvajal ,  Carolina Martinez ,  Carlos Martinez ,  Wim Nest ,  Cristina Serraima

IPC分类号： A61K38/04 ,  A61K38/06 ,  A61P25/00 ,  C07K5/02 ,  C07K5/04 ,  C07K5/08

CPC分类号： C07K5/0827 ,  C07K5/0207 ,  C07K5/021

摘要： The invention relates to compounds having formula (I), which can block the response to chemical substances or thermal stimuli or mediators of inflammation of nociceptors, a production method thereof and compositions containing same. According to the invention, Ar is a phenyl group substituted with one or more halogen groups; R1 is amino, hydroxyl or thiol, all of which may or may not be substituted with formula (II) or with aliphatic or cyclic groups; R2 is H or an alkyl, aryl, aralkyl or acyl group or formula (III); R3 is H or formula (IV); R4 and R6 are H or an aliphatic or cyclic group; R5 is H or formula (V); R7 is H or an aliphatic or cyclic group; Z is amino, hydroxyl or thiol, all of which may or may not be substituted with aliphatic or cyclic groups; W is a linkage or formula (VI); X is a linkage or formula (VII); Y is amino which may or may not be substituted with formula (VIII) or an alkyl, aryl, aralkyl or acyl group; m, q and s can vary between 1 and 9 and n and p can vary between 1 and 10.

摘要翻译： 本发明涉及具有式（I）的化合物，其可以阻止对伤害感受器的化学物质或热刺激或炎症介质的反应，其制备方法和含有它们的组合物。 根据本发明，Ar是被一个或多个卤素基团取代的苯基; R 1是氨基，羟基或硫醇，它们全部可以被或不被式（II）取代或被脂肪族或环状基取代; R 2是H或烷基，芳基，芳烷基或酰基或式（III）; R 3是H或式（IV）; R 4和R 6是H或脂族或环状基团; R 5是H或式（V）; R 7是H或脂族或环状基团; Z是氨基，羟基或硫醇，它们都可以被脂肪族或环状基团取代，也可以不被脂肪族或环状基团取代; W是连接或式（Ⅵ）; X是连接或式（VII）; Y是可被或不被式（Ⅷ）或烷基，芳基，芳烷基或酰基取代的氨基; m，q和s可以在1和9之间变化，n和p可以在1和10之间变化。