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    Compositions affecting programmed cell death and their use in the modification of forestry plant development
    6.
    发明授权
    Compositions affecting programmed cell death and their use in the modification of forestry plant development 失效
    影响程序性细胞死亡的组合物及其在改造林业植物发育中的应用

    公开(公告)号：US06451604B1

    公开(公告)日：2002-09-17

    申请号：US09325932

    申请日：1999-06-04

    申请人： Barry Flinn ,  Annette Lasham

    发明人： Barry Flinn ,  Annette Lasham

    IPC分类号： C12N1582

    CPC分类号： C12N15/8263 ,  C07K14/415

    摘要： Novel isolated polynucleotides associated with programmed cell death and various plant developmental mechanisms are provided, together with genetic constructs comprising such sequences. Methods for the modulation of the content, structure and metabolism of forestry plants, and particularly for the modulation of PCD and various plant developmental mechanisms in forestry plants, are also disclosed, the methods comprising incorporating one or more of the polynucleotides or genetic constructs of the present invention into the genome of a forestry plant.

    摘要翻译： 提供与程序性细胞死亡和各种植物发育机制相关的新型分离的多核苷酸以及包含这种序列的遗传构建体。 还公开了调节林业植物的内容，结构和代谢特别是用于调节林木植物中的PCD和各种植物发育机制的方法，所述方法包括掺入一种或多种多核苷酸或遗传构建体 本发明进入林业植物基因组。

    Methods for modulating apoptotic cell death
    9.
    发明申请
    Methods for modulating apoptotic cell death 审中-公开
    调节凋亡细胞死亡的方法

    公开(公告)号：US20070004666A1

    公开(公告)日：2007-01-04

    申请号：US11501319

    申请日：2006-08-08

    申请人： Annette Lasham ,  James Watson

    发明人： Annette Lasham ,  James Watson

    IPC分类号： A61K48/00 ,  C12N15/09

    CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/4747 ,  C07K14/70578 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/30 ,  C12N2830/32

    摘要： Proteinaceous transcription factors that regulate the transcription of genes and/or the translation of messenger RNA encoding proteins involved in apoptosis, such as CD95 and p53, are disclosed, together with methods for the use of such transcription factors in the modulation of apoptotic cell death. Methods for regulating apoptosis have therapeutic and prophylactic applications for a variety of disorders, including cancer, viral and retroviral infections, neurodegenerative disorders, immune system dysfunction, and other disorders.

    摘要翻译： 公开了调节基因转录和/或编码参与凋亡的信使RNA（如CD95和p53）的蛋白质转录因子，以及在调节凋亡性细胞死亡中使用这​​种转录因子的方法。 用于调节凋亡的方法具有治疗和预防性应用，用于各种疾病，包括癌症，病毒和逆转录病毒感染，神经变性疾病，免疫系统功能障碍和其它疾病。