公开(公告)号：US20100071443A1

公开(公告)日：2010-03-25

申请号：US12284892

申请日：2008-09-25

Applicant: Nathan Wrench ,  Benjamin Gordon ,  Kevin Rathbone ,  Andrew Gow

Inventor： Nathan Wrench ,  Benjamin Gordon ,  Kevin Rathbone ,  Andrew Gow

IPC: G01N11/14 ,  G01N25/00

CPC classification number: G01N11/14 ,  G01N11/16 ,  G01N2203/0222

Abstract: In one general aspect, a rheometer for measuring properties of a sample is disclosed. It can include a first part having a drive portion operatively connected to an actuator and having a contact surface for contacting the sample. The rheometer also includes a second part that has another contact surface for contacting the sample. A first heater is positioned to heat the first part, a second heater is positioned to heat the second part, and a heat pump can heat and cool both the first and second parts.

Abstract translation: 在一般的方面，公开了一种用于测量样品性质的流变仪。 它可以包括具有可操作地连接到致动器并具有用于接触样品的接触表面的驱动部分的第一部分。 流变仪还包括具有用于接触样品的另一个接触表面的第二部分。 定位第一加热器以加热第一部分，第二加热器定位成加热第二部分，并且热泵可以加热和冷却第一部分和第二部分。

公开(公告)号：US20050103066A1

公开(公告)日：2005-05-19

申请号：US10991727

申请日：2004-11-17

Applicant: Andries Botha ,  Christodoulos Toulis ,  Ajay Castelino ,  Andrew Gow

Inventor： Andries Botha ,  Christodoulos Toulis ,  Ajay Castelino ,  Andrew Gow

IPC: E05B15/00 ,  E05B59/00 ,  E05B63/00 ,  E05B63/14 ,  E05C9/04 ,  E05C9/20

CPC classification number: E05C9/042 ,  E05B15/004 ,  E05B59/00 ,  E05B63/0013 ,  E05C9/047 ,  E05C9/20 ,  Y10T70/5226

Abstract: A multi-point lock for a closure includes two or more of a latch (19,20), lift bolt (13) and at least one drive element (16,17) for operating a shoot bolt or remote deadbolt. A drive cam (15), a drive gear (14) and a toothed member (42) coupled to at least one of said lift bolt (13) and at least one said drive element (16,17), said toothed member (42) being in meshed engagement with the drive gear (14), said drive cam (15) being drivingly coupled with the drive gear (14) via a lost motion coupling (38,40). Rotation of the drive cam (15) in one direction can thus actuate the latch (19,20) and in the opposite direction actuate the drive gear (14) to cause movement of the lift bolt (13) and drive element (16,17).

Abstract translation: 用于闭合件的多点锁包括闩锁（19,20），提升螺栓（13）和至少一个驱动元件（16,17）中的两个或多个，用于操作射击螺栓或远程锁死螺栓。 驱动凸轮（15），驱动齿轮（14）和联接到所述提升螺栓（13）和至少一个所述驱动元件（16,17）中的至少一个的齿形构件（42），所述齿形构件 ）与所述驱动齿轮（14）啮合，所述驱动凸轮（15）经由空转联轴器（38,40）与所述驱动齿轮（14）驱动连接。 驱动凸轮（15）在一个方向的旋转可以由此致动闩锁（19,20），并且在相反方向上致动驱动齿轮（14），以引起提升螺栓（13）和驱动元件（16,17）的移动 ）。

公开(公告)号：US20120226240A1

公开(公告)日：2012-09-06

申请号：US13510213

申请日：2010-11-19

Applicant: Tony Bedford ,  Duncan Bishop ,  Andrew Gow ,  Dave Harris ,  Nick Hawson ,  Dominic Lloyd-Lucas ,  Martin Murphy ,  Christophe Royer

Inventor： Tony Bedford ,  Duncan Bishop ,  Andrew Gow ,  Dave Harris ,  Nick Hawson ,  Dominic Lloyd-Lucas ,  Martin Murphy ,  Christophe Royer

IPC: A61M5/315

CPC classification number: A61M5/31591 ,  A61M5/3158 ,  A61M2005/31508

Abstract: A syringe (2) for dispensing a fluid, the syringe including a barrel (4) including a discharge end (10) defining a discharge passage, and a plunger (15) disposed within the barrel, the plunger being adapted to move within the barrel such that the plunger and discharge end define a variable volume chamber within the barrel and the plunger is capable of displacing fluid from the chamber through the discharge passage; wherein the syringe includes a rotational element (20a, 20b, 24a, 24b) adapted to rotate about longitudinal axis of the syringe and which has a first axial orientation relative to the discharge end of the barrel and a first stop is provided on the plunger and/or the barrel which is adapted to limit axial movement of the plunger in the first orientation of the rotational element, and the rotational element has a second axial orientation relative to the discharge end of the barrel in which the first stop is disengaged and movement of the plunger is permitted to a second stop.

Abstract translation: 一种用于分配流体的注射器（2），所述注射器包括包括限定排出通道的排出端（10）的筒（4）和设置在所述筒内的柱塞（15），所述柱塞适于在所述筒 使得柱塞和排出端在筒体内限定可变体积腔室，并且柱塞能够使来自腔室的流体通过排出通道移位; 其中所述注射器包括适于围绕所述注射器的纵向轴线旋转的旋转元件（20a，20b，24a，24b），并且所述旋转元件相对于所述镜筒的排出端具有第一轴向定位，并且在所述柱塞上设置有第一止动件， /或适于限制柱塞在旋转元件的第一方向上的轴向运动的筒体，并且旋转元件相对于筒体的排出端具有第二轴向定向，其中第一止挡件脱开，并且运动 柱塞被允许进行第二次停止。

公开(公告)号：US20070275878A1

公开(公告)日：2007-11-29

申请号：US11784780

申请日：2007-04-09

Applicant: Jonathan Stamler ,  Andrew Gow

Inventor： Jonathan Stamler ,  Andrew Gow

IPC: A61K38/16

CPC classification number: A61K31/00 ,  A61K31/04 ,  A61K31/095 ,  A61K31/195 ,  A61K35/18 ,  A61K38/00 ,  A61K38/44 ,  A61K47/6445 ,  A61K47/6901 ,  C07K14/00 ,  C07K14/805 ,  G01N21/631 ,  G01N21/76 ,  G01N33/721 ,  Y10T436/105831

Abstract: Nitrosylhemoglobin can be produced by introducing gaseous NO into an aqueous solution of hemoglobin. It has been demonstrated that nitrosylhemoglobin in aqueous solution can be converted to SNO-hemoglobin upon introduction of oxygen to the solution, as is postulated to occur in the lungs. Nitrosylhemoglobin can be used in methods to produce the physiological effects of NO, for example, to reduce vasoconstriction and to inhibit platelet aggregation.

公开(公告)号：US20130303994A1

公开(公告)日：2013-11-14

申请号：US13988467

申请日：2011-11-21

Applicant: Maxime Gaillot ,  Kathryn Farrell ,  Andrew Gow ,  George Perkins

Inventor： Maxime Gaillot ,  Kathryn Farrell ,  Andrew Gow ,  George Perkins

IPC: A61J1/20 ,  A61M5/31

CPC classification number: A61J1/2096 ,  A61J1/201 ,  A61J1/2055 ,  A61M5/31

Abstract: The invention relates to an adapter which comprises a base having a container attachment portion on a first side and a needle hub attachment portion on a second side opposite the first side. The adapter includes a puncturing member extending along a first axis for entering a container inserted into the container attachment portion. The adapter includes a channel extending substantially along the first axis from the needle hub attachment portion, through the base and along the puncturing member to an axial outlet at, or adjacent, a tip of the puncturing member. The adapter is configured so that a needle comprising a shaft extending from a hub can be inserted into the adapter such that the hub engages the hub attachment portion and the shaft extends through the base and within the puncturing member.

Abstract translation: 本发明涉及一种适配器，其包括在第一侧上具有容器附接部分的基座和与第一侧相对的第二侧上的针毂连接部分。 适配器包括沿着第一轴延伸的穿刺构件，用于进入插入到容器附接部分中的容器。 适配器包括从针座安装部分基本上沿着第一轴线延伸的通道，穿过基座并且沿着穿刺构件延伸到穿刺构件的尖端处或相邻的轴向出口。 适配器被构造成使得包括从轮毂延伸的轴的针可以插入到适配器中，使得轮毂接合轮毂安装部分，并且轴延伸穿过基座和穿刺构件。

公开(公告)号：US20070191478A1

公开(公告)日：2007-08-16

申请号：US11231162

申请日：2005-09-20

Applicant: Jonathan Stamler ,  Eric Toone ,  Andrew Gow

Inventor： Jonathan Stamler ,  Eric Toone ,  Andrew Gow

IPC: A61K31/21

CPC classification number: C12N5/0641 ,  A61K31/197 ,  A61K31/21 ,  A61K33/00 ,  A61K33/04 ,  A61M2202/0275 ,  A61K2300/00

Abstract: Treatment of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction and/or inflammation comprises administering into the lungs as a gas a compound with an NO group which does not form NO2/NOx in the presence of oxygen or reactive oxygen species at body temperature. Treatment of cardiac and blood disorders, e.g., angina, myocardial infarction, heart failure, hypertension, sickle cell disease and clotting disorders, comprises administering into the lungs as a gas, a compound which reacts with cysteine in hemoglobin and/or dissolves in blood and has an NO group which is bound in said compound so that it does not form NO2/NOx in the presence of oxygen or reactive oxygen species at body temperature. Exemplary of the compound administered in each case is ethyl nitrite. Treatment of patient in need of improved oxygenation, blood flow of and/or thinning of blood comprises providing in the patient a therapeutic amount of red blood cells loaded with nitrosylated hemoglobin. A method is directed to screening drugs that increase level of nitrosoglutathione in airway lining fluid.

Abstract translation: 与低氧血症和/或平滑肌收缩和/或炎症相关的肺部疾病的治疗包括以肺部作为气体给予具有不形成NO 2的NO组的化合物 在体温存在氧或活性氧的情况下。 治疗心脏和血液疾病，例如心绞痛，心肌梗死，心力衰竭，高血压，镰状细胞病和凝血障碍，包括作为气体给予肺，与血红蛋白中的半胱氨酸反应和/或溶解于血液中的化合物和 具有在所述化合物中结合的NO基团，使得其在体温存在氧或活性氧的情况下不形成NO 2 / NO x 2 x。 在每种情况下施用的化合物的实例是亚硝酸乙酯。 治疗需要改善氧合，血流和/或血液变薄的患者包括在患者体内提供加载有亚硝基化血红蛋白的治疗量的红细胞。 一种方法是用于筛选增加气道衬里液中亚硝基谷胱甘肽水平的药物。