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公开(公告)号：US06197947B1
公开(公告)日：2001-03-06
申请号：US09318443
申请日：1999-05-25
IPC分类号： C07H2104
CPC分类号： C07K14/4705
摘要： The present invention provides a vertebrate translation initiation factor (eIF-4AIII), that plays a role in the differentiation of an embryonic cell to an epideimal cell. This translation initiation factor interacts with BMP-4 in a positive regulatory loop. The nucleic acid and amino acid sequences are also disclosed. Also disclosed are methods of using the translation initiation factor, nucleic acids encoding the same, and corresponding antibodies and the like.
摘要翻译： 本发明提供了一种脊椎动物翻译起始因子（eIF-4AIII），其在胚胎细胞向外源细胞的分化中起作用。 该翻译起始因子与BMP-4在阳性调节环中相互作用。 还公开了核酸和氨基酸序列。 还公开了使用翻译起始因子，编码翻译起始因子的核酸，以及相应的抗体等的方法。
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公开(公告)号：US06337392B1
公开(公告)日：2002-01-08
申请号：US09306042
申请日：1999-05-06
IPC分类号： C07H2104
CPC分类号： C07K14/4705
摘要： The present invention discloses nucleic acids containing transcriptional control elements that are lens transcriptional control elements. One such lens transcriptional control element is exemplified by the control element of the Pax-6 gene. Methods of using these lens transcriptional control elements for drug assays, diagnostics and for identifying transcription factors involved in lens development are also disclosed.
摘要翻译： 本发明公开了含有作为透镜转录控制元件的转录控制元件的核酸。 一种这样的透镜转录控制元件由Pax-6基因的对照元件举例说明。 还公开了使用这些透镜转录控制元件用于药物测定，诊断和鉴定涉及透镜发育的转录因子的方法。
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公开(公告)号：US07264968B2
公开(公告)日：2007-09-04
申请号：US10721692
申请日：2003-11-25
IPC分类号： C12N5/00
CPC分类号： C07K14/4702 , A61K38/00 , A61K38/22 , A61K38/57 , C07K14/46 , C07K14/71 , A61K2300/00
摘要： The present invention makes available a method for inducing neuronal differentiation and preventing the death or degeneration of neuronal cells both in vitro and in vivo. The subject method stems from the unexpected finding that, contrary to traditional understanding of neural induction, the default fate of ectodermal tissue is neuronal rather than mesodermal and/or epidermal. In particular, it has been discovered that preventing or antagonizing a signaling pathway in a cell for a growth factor of the TGF-β family can result in neuronal differentiation of that cell.
摘要翻译： 本发明提供一种用于诱导神经元分化并在体外和体内预防神经元细胞的死亡或退化的方法。 主题方法源于意想不到的发现，与传统的神经诱导理解相反，外胚层组织的默认命运是神经元而不是中胚层和/或表皮。 特别地，已经发现，预防或拮抗TGF-β家族生长因子的细胞中的信号传导途径可导致该细胞的神经元分化。
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公开(公告)号：US06686198B1
公开(公告)日：2004-02-03
申请号：US08835279
申请日：1997-04-09
IPC分类号： C12N500
CPC分类号： C07K14/4702 , A61K38/00 , A61K38/22 , A61K38/57 , C07K14/46 , C07K14/71 , A61K2300/00
摘要： The present invention makes available a method for inducing neuronal differentiation and preventing the death or degeneration of neuronal cells both in vitro and in vivo. The subject method stems from the unexpected finding that, contrary to traditional understanding of neural induction, the default fate of ectodermal tissue is neuronal rather than mesodermal and/or epidermal. In particular, it has been discovered that preventing or antagonizing a signaling pathway in a cell for a growth factor of the TGF-&bgr; family can result in neuronal differentiation of that cell.
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公开(公告)号：US5952213A
公开(公告)日：1999-09-14
申请号：US6675
申请日：1998-01-13
CPC分类号： C12N9/12 , C07K2319/00
摘要： The present invention provides a unique src-family kinase (SFK) that plays a key role in the transformation of early-stage embryonic cells to mesodermal cells. Furthermore, this src-family kinase is likely to be a proto-oncogene. The nucleic acid and amino acid sequences are disclosed.
摘要翻译： 本发明提供了一种独特的src家族激酶（SFK），其在早期胚胎细胞向中胚层细胞转化中起关键作用。 此外，这种src家族激酶可能是原癌基因。 公开了核酸和氨基酸序列。
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公开(公告)号：US20080261879A1
公开(公告)日：2008-10-23
申请号：US11981846
申请日：2007-10-31
CPC分类号： C07K14/71 , A61K31/17 , A61K31/513 , A61K31/519 , A61K31/7004 , A61K31/7068 , A61K38/00 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/22 , A61K38/57 , C07K14/46 , C07K14/4702 , A61K2300/00
摘要： The present invention makes available a method for inducing neuronal differentiation and preventing the death or degeneration of neuronal cells both in vitro and in vivo. The subject method stems from the unexpected finding that, contrary to traditional understanding of neural induction, the default fate of ectodermal tissue is neuronal rather than mesodermal and/or epidermal. In particular, it has been discovered that preventing or antagonizing a signaling pathway in a cell for a growth factor of the TGF-β family can result in neuronal differentiation of that cell.
摘要翻译： 本发明提供一种用于诱导神经元分化并在体外和体内预防神经元细胞的死亡或退化的方法。 主题方法源于意想不到的发现，与传统的神经诱导理解相反，外胚层组织的默认命运是神经元而不是中胚层和/或表皮。 特别地，已经发现，预防或拮抗TGF-β家族生长因子的细胞中的信号传导途径可导致该细胞的神经元分化。
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