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公开(公告)号：US20220306146A1
公开(公告)日：2022-09-29
申请号：US17836115
申请日：2022-06-09
申请人： Alexander Yemelyanov
发明人： Alexander Yemelyanov
摘要： A system includes a processor to: receive a description of a current decision that includes selecting an option; repeatedly display the description; for each option, receive an indication of selection of scale text specifying a degree of intensity or intensity for achieving or avoiding a possible outcome of the option, and derive an overall motivation based on the at least one selection; identify a best option based on the overall motivations; display the best option; compare the overall motivation of the best option to a threshold; in response to being less than the threshold, display a warning and a prompt for the operator to further consider the current decision; compare the overall motivation of the best option to the others; and in response to not exceeding all other overall motivations, by at least a threshold of difference, present a proximity warning and the prompt.
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公开(公告)号：US11794771B2
公开(公告)日：2023-10-24
申请号：US17836115
申请日：2022-06-09
申请人： Alexander Yemelyanov
发明人： Alexander Yemelyanov
CPC分类号： B60W50/14 , G06N5/045 , B60W2050/146
摘要： A system includes a processor to: receive a description of a current decision that includes selecting an option; repeatedly display the description; for each option, receive an indication of selection of scale text specifying a degree of intensity or intensity for achieving or avoiding a possible outcome of the option, and derive an overall motivation based on the at least one selection; identify a best option based on the overall motivations; display the best option; compare the overall motivation of the best option to a threshold; in response to being less than the threshold, display a warning and a prompt for the operator to further consider the current decision; compare the overall motivation of the best option to the others; and in response to not exceeding all other overall motivations, by at least a threshold of difference, present a proximity warning and the prompt.
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3.发明授权Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma 有权糖皮质激素受体激动剂与蛋白酶抑制剂联合用于治疗白血病和骨髓瘤的协同作用公开(公告)号：US09126997B1
公开(公告)日：2015-09-08
申请号：US13226865
申请日：2011-09-07
IPC分类号： C07D471/02 , C07D271/00 , A01N43/42
CPC分类号： C07D471/02 , A01N43/42 , C07D271/00
摘要： Disclosed are methods and pharmaceutical compositions for treating diseases, disorders, and conditions associated with glucocorticoid receptor (GR) expression and activity. The disclosed methods typically include administering to a patient in need thereof a proteasome inhibitor and administering to the patient in need thereof a glucocorticoid receptor (GR) agonist, either before, concurrently with, or after the proteasome inhibitor is administered.
摘要翻译： 公开了用于治疗与糖皮质激素受体（GR）表达和活性相关的疾病，病症和病症的方法和药物组合物。 所公开的方法通常包括向有需要的患者施用蛋白酶体抑制剂，并且在施用蛋白酶体抑制剂之前，同时或之后向有需要的患者施用糖皮质激素受体（GR）激动剂。
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4.发明申请Substituted Phenyl Aziridine Precursor Analogs as Modulators of Steroid Receptor Activities 审中-公开取代的苯基氮丙啶前体类似物作为类固醇受体活性的调节剂公开(公告)号：US20090156672A1
公开(公告)日：2009-06-18
申请号：US12335911
申请日：2008-12-16
IPC分类号： A61K31/135 , A61P35/00 , A61K31/216
CPC分类号： A61K31/396 , A61K31/135 , A61K31/216 , A61K31/222 , A61K45/06 , C07C229/38 , C12Q1/6886 , C12Q2600/158 , G01N33/57434
摘要： Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.
摘要翻译： 公开了用于调节一种或多种类固醇受体活性的方法和药物组合物。 方法通常使用，药物组合物通常包括一个或多个取代的苯基氮丙啶前体，它们各自的氮丙啶，其类似物，其衍生物或其药学上可接受的盐，例如CpdA。 方法和组合物可用于治疗与糖皮质激素受体活性，雄激素受体活性或二者相关的疾病，病症和病症，例如癌症，寻常痤疮和脱发。
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公开(公告)号：US11358611B2
公开(公告)日：2022-06-14
申请号：US17335456
申请日：2021-06-01
申请人： Alexander Yemelyanov
发明人： Alexander Yemelyanov
摘要： A system includes a processor to: receive a description of a current decision that includes selecting an option; repeatedly display the description; for each option, receive an indication of selection of scale text specifying a degree of intensity or intensity for achieving or avoiding a possible outcome of the option, and derive an overall motivation based on the at least one selection; identify a best option based on the overall motivations; display the best option; compare the overall motivation of the best option to a threshold; in response to being less than the threshold, display a warning and a prompt for the operator to further consider the current decision; compare the overall motivation of the best option to the others; and in response to not exceeding all other overall motivations, by at least a threshold of difference, present a proximity warning and the prompt.
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公开(公告)号：US20210370965A1
公开(公告)日：2021-12-02
申请号：US17335456
申请日：2021-06-01
申请人： Alexander Yemelyanov
发明人： Alexander Yemelyanov
摘要： A system includes a processor to: receive a description of a current decision that includes selecting an option; repeatedly display the description; for each option, receive an indication of selection of scale text specifying a degree of intensity or intensity for achieving or avoiding a possible outcome of the option, and derive an overall motivation based on the at least one selection; identify a best option based on the overall motivations; display the best option; compare the overall motivation of the best option to a threshold; in response to being less than the threshold, display a warning and a prompt for the operator to further consider the current decision; compare the overall motivation of the best option to the others; and in response to not exceeding all other overall motivations, by at least a threshold of difference, present a proximity warning and the prompt.
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