公开(公告)号：US07148208B2

公开(公告)日：2006-12-12

申请号：US10382217

申请日：2003-03-05

申请人： Raphael Barkan ,  Alexander Mirimsky

发明人： Raphael Barkan ,  Alexander Mirimsky

IPC分类号： A61K31/105 ,  A61K31/145 ,  A61K31/535 ,  A61K31/425 ,  A61K31/17 ,  A61K31/715 ,  A61K31/66

CPC分类号： A61K31/66 ,  A61K31/17 ,  A61K2300/00

摘要： S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting. The compositions of the invention are also effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.

摘要翻译： S-烷基硫代硫脲衍生物如S-乙基异硫脲二乙基磷酸酯用于治疗头痛，特别是偏头痛，以及用于预防或治疗恶心和呕吐。 本发明的组合物还有效预防或缓解与偏头痛或其它医学病症如化学疗法或放射疗法相关的呕吐以及其他偏头痛症状，包括恐慌症和恐惧症。

公开(公告)号：US08673979B2

公开(公告)日：2014-03-18

申请号：US11550548

申请日：2006-10-18

申请人： Raphael Barkan ,  Alexander Mirimsky

发明人： Raphael Barkan ,  Alexander Mirimsky

IPC分类号： A01N47/28 ,  A61K31/17

CPC分类号： A61K31/66 ,  A61K31/17 ,  A61K2300/00

摘要： S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting. The compositions of the invention are also effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.

摘要翻译： S-烷基硫代硫脲衍生物如S-乙基异硫脲二乙基磷酸酯用于治疗头痛，特别是偏头痛，以及用于预防或治疗恶心和呕吐。 本发明的组合物还有效预防或缓解与偏头痛或其它医学病症如化学疗法或放射疗法相关的呕吐以及其他偏头痛症状，包括恐慌症和恐惧症。

公开(公告)号：US20090018206A1

公开(公告)日：2009-01-15

申请号：US12066041

申请日：2006-09-06

申请人： Refael Barkan ,  Alexander Mirimsky ,  Ze've Katzir ,  Victor Ghicavii

发明人： Refael Barkan ,  Alexander Mirimsky ,  Ze've Katzir ,  Victor Ghicavii

IPC分类号： A61K31/14 ,  A61P9/02

CPC分类号： A61K31/145 ,  A61K31/6615

摘要： The present invention relates to the use of S-alkylisothiouronium derivatives, including S-ethylisothiouronium diethylphosphate, for stabilizing blood pressure in hemodialysis patients. The compositions of the invention are effective in preventing hypotension in hemodialysis patients.

摘要翻译： 本发明涉及S-烷基异硫脲衍生物（包括S-乙基异硫脲二乙基磷酸酯）用于稳定血液透析患者血压的用途。 本发明的组合物可有效预防血液透析患者的低血压。

公开(公告)号：US20070088005A1

公开(公告)日：2007-04-19

申请号：US11550548

申请日：2006-10-18

申请人： Raphael Barkan ,  Alexander Mirimsky

发明人： Raphael Barkan ,  Alexander Mirimsky

IPC分类号： A61K31/66

CPC分类号： A61K31/66 ,  A61K31/17 ,  A61K2300/00

摘要： S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting. The compositions of the invention are also effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.

摘要翻译： S-烷基硫代硫脲衍生物如S-乙基异硫脲二乙基磷酸酯用于治疗头痛，特别是偏头痛，以及用于预防或治疗恶心和呕吐。 本发明的组合物还有效预防或缓解与偏头痛或其它医学病症如化学疗法或放射疗法相关的呕吐以及其他偏头痛症状，包括恐慌症和恐惧症。