公开(公告)号：US20150133878A1

公开(公告)日：2015-05-14

申请号：US14600505

申请日：2015-01-20

Applicant: Eugene de Juan, JR. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton ,  Alexander J. Gould

Inventor： Eugene de Juan, JR. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton ,  Alexander J. Gould

IPC: A61F9/00 ,  A61L27/16 ,  A61L27/02 ,  A61K9/00

CPC classification number: A61F9/0017 ,  A61B17/00234 ,  A61K9/0051 ,  A61K47/34 ,  A61L27/025 ,  A61L27/16

Abstract: A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

Abstract translation: 舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。 保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。 保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。 插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。 插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

公开(公告)号：US08939948B2

公开(公告)日：2015-01-27

申请号：US13618052

申请日：2012-09-14

Applicant: Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton ,  Alexander J. Gould

Inventor： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton ,  Alexander J. Gould

IPC: A61M35/00 ,  A61B17/00 ,  A61F9/00 ,  A61K9/00 ,  A61K47/34

CPC classification number: A61F9/0017 ,  A61B17/00234 ,  A61K9/0051 ,  A61K47/34 ,  A61L27/025 ,  A61L27/16

Abstract: A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

Abstract translation: 舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。 保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。 保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。 插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。 插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。