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公开(公告)号：US08497259B2
公开(公告)日：2013-07-30
申请号：US13523086
申请日：2012-06-14
IPC分类号： A01N43/00 , A01N35/02 , A61K31/33 , A61K31/115
CPC分类号： A61K31/115 , A61K9/2009 , A61K9/2018
摘要： There is proposed a method for using a preparation for lowering the cholesterol level of a patient. In preferred embodiments, the preparation essentially consists of an active substance being an aqueous solution of formaldehyde with a concentration of 36.5-40%, the active substance constitutes 2-6 weight units, and an additive being an isotonic solution of sodium chloride with a concentration of 0.85-0.95%, the additive constitutes from 998 to 994 weight units accordingly, to make the total of 1000 weight units. The method includes administering the preparation to the patient in the form of intramuscular injections with a predetermined dose at a predetermined time interval, thereby lowering the cholesterol level of the patient. It is preferable to choose the predetermined time interval from the group consisting of 7, 21, 30, and 60 days. It is also preferable to choose the predetermined dose in the amount of 5 mL.
摘要翻译： 提出了使用降低患者胆固醇水平的制剂的方法。 在优选的实施方案中，制剂主要由活性物质组成，活性物质为浓度为36.5-40％的甲醛水溶液，活性物质为2-6重量单位，添加剂为浓度为氯化钠的等渗溶液 为0.85-0.95％，相应地添加量为998〜994重量份，共计1000重量单位。 该方法包括以预定剂量以预定的时间间隔以肌内注射的形式向患者施用该制剂，从而降低患者的胆固醇水平。 优选从7,21,30和60天组成的组中选择预定的时间间隔。 还优选选择5mL的预定剂量。
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公开(公告)号：US20120252903A1
公开(公告)日：2012-10-04
申请号：US13523086
申请日：2012-06-14
IPC分类号： A61K31/115 , A61P3/06
CPC分类号： A61K31/115 , A61K9/2009 , A61K9/2018
摘要： There is proposed a method for using a preparation for lowering the cholesterol level of a patient. In preferred embodiments, the preparation essentially consists of an active substance being an aqueous solution of formaldehyde with a concentration of 36.5-40%, the active substance constitutes 2-6 weight units, and an additive being an isotonic solution of sodium chloride with a concentration of 0.85-0.95%, the additive constitutes from 998 to 994 weight units accordingly, to make the total of 1000 weight units. The method includes administering the preparation to the patient in the form of intramuscular injections with a predetermined dose at a predetermined time interval, thereby lowering the cholesterol level of the patient. It is preferable to choose the predetermined time interval from the group consisting of 7, 21, 30, and 60 days. It is also preferable to choose the predetermined dose in the amount of 5 mL.
摘要翻译： 提出了使用降低患者胆固醇水平的制剂的方法。 在优选的实施方案中，制剂主要由活性物质组成，活性物质为浓度为36.5-40％的甲醛水溶液，活性物质为2-6重量单位，添加剂为浓度为氯化钠的等渗溶液 为0.85-0.95％，相应地添加量为998〜994重量份，共计1000重量单位。 该方法包括以预定剂量以预定的时间间隔以肌内注射的形式向患者施用该制剂，从而降低患者的胆固醇水平。 优选从7,21,30和60天组成的组中选择预定的时间间隔。 还优选选择5mL的预定剂量。
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公开(公告)号：US07682419B2
公开(公告)日：2010-03-23
申请号：US10540662
申请日：2003-04-16
申请人： Viatcheslav Dmitrievich Shapovalov , Konstantin Sergeevich Fokin , Aleksandr Nikolaevich Shokhin
发明人： Viatcheslav Dmitrievich Shapovalov , Konstantin Sergeevich Fokin , Aleksandr Nikolaevich Shokhin
CPC分类号： C01B17/96 , C22B3/06 , C22B3/065 , C22B3/08 , C22B3/44 , C22B11/04 , C22B15/0073 , C22B19/22 , C22B23/0438 , Y02P10/234 , Y02P10/236
摘要： Recovery of nonferrous, rare and precious metals from sulfide minerals and concentrates is described. The hydrometallurgical method of sulfide minerals and concentrates processing, involving sulfide minerals oxidation in aqueous medium using nitrogen oxides, provides that the sulfide materials containing slurry are subjected to oxidation of the sulfide which is realized under controlled conditions of the slurry acidity. Constant neutralization of sulfuric acid formed as a result of the sulfides oxidation is provided. The sulfuric acid is neutralized to acidity level, at which no formation of elementary sulfur occurs, while natural or artificial substances, such as CaC03, MgC03, Ca(OH)2, CaO, NaOH, CaHP04 etc., are used as acidity neutralizers. Oxidation of sulfide minerals is realized under agitation. Oxidation is realized in the range of 20-90° C., mainly in the range of 65-85° C. The liquid-to-solid ratio varies from 1:1 to 5:1, depending on effectiveness of the required precipitate formation and proceeding of the oxidation.
摘要翻译： 描述了从硫化物矿物和浓缩物中回收有色金属，稀有金属和贵金属。 使用氮氧化物在含水介质中硫化矿物氧化的硫化物矿物和浓缩物加工的湿法冶金方法提供了含硫化物料浆料的硫化物的氧化，这在硫酸盐的控制条件下实现。 提供了由于硫化物氧化而形成的硫酸的恒定中和。 硫酸中和至酸性水平，不会形成元素硫，而天然或人造物质如CaCO 3，MgCO 3，Ca（OH）2，CaO，NaOH，CaHPO 4等用作酸性中和剂。 在搅拌下实现硫化矿物的氧化。 氧化实现在20-90℃的范围内，主要在65-85℃的范围内。根据所需沉淀物形成的有效性，液 - 固比率为1:1至5:1 并进行氧化。
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公开(公告)号：US20100144889A1
公开(公告)日：2010-06-10
申请号：US12451459
申请日：2008-04-02
IPC分类号： A61K31/115 , A61P3/06
CPC分类号： A61K31/115 , A61K9/2009 , A61K9/2018
摘要： The invention relates to medicine and can be used for producing a medicinal agent for normalising the cholesterol level. The aim of the invention is to develop a physiologically acceptable cholesterol-control agent which is nontoxic and does not cause addiction of organism. In preferred embodiments, the method for producing said agent consists in using 2-6 weight parts of a 36.5-40.0% formaldehyde medicinal solution and in adding 998-994 weight parts of a sterile 0.85-0.95% sodium chloride solution which is used for injection in such a way as to produce a 0.07-024% formaldehyde solution. The agent is stored at a temperature of 15-35° C. It also encompasses a method for treatment of patients for lowering their cholesterol levels that comprises administering the agent to the patients as intramuscular injections with a predetermined dose at a predetermined time interval.
摘要翻译： 本发明涉及药物，可用于制备用于使胆固醇水平正常化的药剂。 本发明的目的是开发一种无毒的生理学可接受的胆固醇控制剂，并且不会引起生物体成瘾。 在优选的实施方案中，制备所述试剂的方法包括使用2-6重量份的36.5-40.0％甲醛药用溶液，并加入998-994重量份的用于注射的无菌0.85-0.95％氯化钠溶液 以这种方式产生0.07-024％的甲醛溶液。 该试剂在15-35℃的温度下储存。它还包括治疗患者降低其胆固醇水平的方法，其包括以预定剂量以预定的时间间隔肌内注射给予患者药剂。
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