公开(公告)号：US20070173466A1

公开(公告)日：2007-07-26

申请号：US10549474

申请日：2004-03-05

申请人： Katsuo Sueishi ,  Yoshikazu yonemitsu ,  Akihisa Yamashita ,  Akihiko Yoshimura ,  Mamoru Hasegawa

发明人： Katsuo Sueishi ,  Yoshikazu yonemitsu ,  Akihisa Yamashita ,  Akihiko Yoshimura ,  Mamoru Hasegawa

IPC分类号： A61K31/7105

CPC分类号： A61K31/7088 ,  A61K38/00 ,  C07K14/4703

摘要： The present invention relates to methods for treating inflammatory diseases accompanied by bone destruction, comprising the step of administering a viral vector comprising a gene which inhibits signal transduction mediated by fibroblast growth factor-2 (FGF2)-FGF receptor 1-Ras-Raf-MAP kinase to a diseased region. Furthermore, the present invention relates to therapeutic compositions for inflammatory diseases accompanied by bone destruction, which comprise these vectors. By inhibiting FGF2 signal transduction through local administration of viral vectors, both inflammation and bone destruction in inflammatory bone destruction were simultaneously suppressed. The present invention provides disease-specific and effective therapeutic methods, and therapeutic compositions for inflammatory diseases such as osteoarthritis, for which therapy has so far been difficult.

摘要翻译： 本发明涉及用于治疗伴随骨破坏的炎性疾病的方法，其包括施用包含抑制由成纤维细胞生长因子-2（FGF2）-FGF受体1-Ras-Raf-MAP介导的信号转导的基因的病毒载体的步骤 激酶到病变区域。 此外，本发明涉及包含这些载体的伴随骨破坏的炎性疾病的治疗组合物。 通过局部施用病毒载体抑制FGF2信号转导，同时抑制炎性骨破坏中的炎症和骨破坏。 本发明提供疾病特异性和有效的治疗方法，以及用于迄今难以治疗的炎性疾病如骨关节炎的治疗组合物。

公开(公告)号：US06462720B1

公开(公告)日：2002-10-08

申请号：US09440390

申请日：1999-11-15

申请人： Akihisa Yamashita ,  Kojiro Minami ,  Hirofumi Fujimoto ,  Katsunori Hirasawa ,  Masatoshi Mukai ,  Yutaka Tsuji

发明人： Akihisa Yamashita ,  Kojiro Minami ,  Hirofumi Fujimoto ,  Katsunori Hirasawa ,  Masatoshi Mukai ,  Yutaka Tsuji

IPC分类号： G09G500

CPC分类号： F41J5/056 ,  A63F9/0291

摘要： There is provided a light-emitting display device which is resistive to shock and vibration and a display switching method comprising: a forward transparent plate 322a having a light scattering portion for a predetermined design pattern relative to a surface direction thereof, a backward transparent plate 322b having a light scattering portion for a predetermined design pattern relative to a surface direction in which the second-mentioned design pattern is different from the first-mentioned design pattern of the light scattering portion of the forward transparent plate, a light source 324 for the forward transparent plate for supplying incidence of light into the forward transparent plate from an end surface of the forward transparent plate, and an other light source 325 for the backward transparent plate for supplying incidence of light into the backward transparent plate from an end surface of the backward transparent plate, so that switching is made from and to emitting and quenching of the backward transparent plate. At the time of luminescence (emitting), the design pattern of the backward panel is synthesized and deleted at the time of quenching.

摘要翻译： 提供了一种耐冲击和振动的发光显示装置和显示切换方法，包括：具有相对于其表面方向具有预定设计图案的光散射部分的前透明板322a，向后透明板322b 具有相对于第二种设计图案与前透明板的光散射部分的第一种设计图案不同的表面方向的预定设计图案的光散射部分，用于前方透明板的光源324 透明板，用于从前透明板的端面向正透明板提供光入射;以及用于向后透明板的另一个光源325，用于从后向透明板的后表面提供光入射到后透明板 透明板，使得切换由发射和去离子 g反向透明板。 在发光（发光）时，在淬灭时合成和删除后面板的设计图案。

公开(公告)号：US06234476B1

公开(公告)日：2001-05-22

申请号：US09488117

申请日：2000-01-20

申请人： Akihisa Yamashita ,  Kojiro Minami ,  Eita Kada ,  Hideki Kotani ,  Yusuke Fujimoto ,  Hajime Dohki

发明人： Akihisa Yamashita ,  Kojiro Minami ,  Eita Kada ,  Hideki Kotani ,  Yusuke Fujimoto ,  Hajime Dohki

IPC分类号： A63F700

CPC分类号： A63F7/3603 ,  A63F7/0632

摘要： An air hockey game apparatus allows game players to appropriately recognize statuses such as a game progress status, thereby effectively improving amusement characteristics. The air hockey game apparatus has a puck sliding surface having blowholes for blowing air to float a puck, an air-blower for blowing and sending air toward blowholes, a puck-reflecting frame around the puck sliding surface, and goals on the puck sliding surface. In the air hockey game apparatus, at least one portion of the puck sliding surface is transparent, and display sections are provided under the transparent portion, of which the display mode is changeable. Also, display-mode-setting units for setting the display mode of the display sections are provided, thereby controlling the display sections so as to be in the set display mode.

摘要翻译： 空中曲棍球游戏装置允许游戏者适当地识别诸如游戏进行状态的状态，从而有效地改善娱乐特性。 空气曲棍球游戏装置具有一个具有用于吹动空气以浮起圆盘的气孔的圆盘滑动表面，用于吹送并将空气吹向气孔的鼓风机，围绕冰球滑动表面的圆盘反射框架，以及圆盘滑动表面上的目标 。 在空中曲棍球游戏装置中，圆盘滑动面的至少一部分是透明的，并且显示部分设置在显示模式可变的透明部分的下方。 此外，提供了用于设置显示部分的显示模式的显示模式设置单元，从而将显示部分控制为处于设定显示模式。

公开(公告)号：US06200236B1

公开(公告)日：2001-03-13

申请号：US09149668

申请日：1998-09-09

申请人： Kojiro Minami ,  Toshimitsu Oishi ,  Akihisa Yamashita ,  Hideki Kotani ,  Hirofumi Fujimoto ,  Katsunori Hirasawa

发明人： Kojiro Minami ,  Toshimitsu Oishi ,  Akihisa Yamashita ,  Hideki Kotani ,  Hirofumi Fujimoto ,  Katsunori Hirasawa

IPC分类号： A63B6704

CPC分类号： A63B69/406 ,  A63B2069/402 ,  A63B2102/16

摘要： A table tennis apparatus includes a ball projecting section disposed rearward of one playing surface of a table for projecting balls towards the other playing surface, a moving mechanism for allowing ball projecting section to be moved laterally, a detecting unit for detecting which side the balls have dropped on one playing surface in the lateral direction, and a driving and controlling unit for driving the moving mechanism according to the drop positions of the balls detected by the detecting unit, and for moving the ball projecting section towards the drop positions of the balls. The moving mechanism includes a guide rail disposed along a lateral direction, and a base having the ball projecting section mounted thereon, and slidably disposed on the guide rail.

摘要翻译： 乒乓球装置包括设置在桌子的一个玩具表面的后方的球形突出部，用于将球朝向另一个游戏表面投射;移动机构，用于允许球投射部分横向移动;检测单元，用于检测球的哪一侧 在横向上落在一个游戏表面上，以及驱动和控制单元，用于根据由检测单元检测到的滚珠的落下位置来驱动移动机构，并且用于将球投射部分朝向球的下落位置移动。 移动机构包括沿横向设置的导轨，以及安装有球状突起部的底座，并且可滑动地设置在导轨上。

公开(公告)号：US06786848B2

公开(公告)日：2004-09-07

申请号：US10236380

申请日：2002-09-05

申请人： Akihisa Yamashita ,  Shin Terao ,  Shintaro Ohsato

发明人： Akihisa Yamashita ,  Shin Terao ,  Shintaro Ohsato

IPC分类号： A63B2100

CPC分类号： A63B24/0087 ,  A63B21/005 ,  A63B22/001 ,  A63B22/0605 ,  A63B2024/0012 ,  A63B2024/009 ,  A63B2024/0096 ,  A63B2071/0644 ,  A63B2220/05 ,  A63B2220/803 ,  A63B2230/06 ,  A63F13/08 ,  A63F13/10 ,  A63F13/212 ,  A63F13/245 ,  A63F13/65 ,  A63F13/803 ,  A63F2300/1012 ,  A63F2300/69 ,  A63F2300/8017 ,  Y10S482/90

摘要： An exercise assisting apparatus including a cycling machine, a rotation sensor for detecting pedaling movement of the cycling machine, a pulse sensor for detecting the pulse rate of the user, an exercise monitoring unit for monitoring the pulse rate of the user based on the detection results of the rotation sensor and the pulse sensor and a monitor for displaying a background image and a role-playing character. The apparatus also includes an image processor for causing the role-playing character to make a simulated motion related to the pedaling movement within the background image on the monitor based on the detection result of the rotation sensor, a game executing unit for causing the roll-playing character to jump, and a game evaluating unit for giving a higher evaluation when a landing position after the jump is closer to the position reached when the jump is made at a preset target pulse rate.

摘要翻译： 一种运动辅助装置，包括循环机，用于检测循环机器的踏板运动的旋转传感器，用于检测用户的脉搏速率的脉冲传感器，用于基于检测结果监视用户的脉搏率的运动监视单元 的旋转传感器和脉冲传感器以及用于显示背景图像和角色扮演角色的监视器。 该装置还包括一个图像处理器，用于使角色扮演角色基于旋转传感器的检测结果在监视器上的背景图像内进行与踏板运动相关的模拟运动;游戏执行单元， 演奏角色跳跃，以及游戏评价单元，用于当跳跃后的着陆位置更接近以预设的目标脉搏速率进行跳跃时到达的位置时给出较高的评估。

公开(公告)号：USD465243S1

公开(公告)日：2002-11-05

申请号：US29148975

申请日：2001-09-28

申请人： Yoshitsugu Isetani ,  Akihisa Yamashita ,  Hideki Kotani ,  Shingo Onkoshi ,  Masahiro Moriyama

设计人： Yoshitsugu Isetani ,  Akihisa Yamashita ,  Hideki Kotani ,  Shingo Onkoshi ,  Masahiro Moriyama

公开(公告)号：US20070068017A1

公开(公告)日：2007-03-29

申请号：US11526438

申请日：2006-09-25

申请人： Yuji Tamura ,  Hiroyuki Wada ,  Akihisa Yamashita

发明人： Yuji Tamura ,  Hiroyuki Wada ,  Akihisa Yamashita

IPC分类号： G01C15/00

CPC分类号： A01K15/025 ,  A01K15/027

摘要： An optical pet guiding apparatus is provided with a light emitting section for emitting a light beam in a specified direction, direction changing sections for changing the facing direction of the light emitting section in a two-dimensional direction, and motors for causing the direction changing sections to change the facing direction of the light emitting section. The direction changing sections include a transversely changing section for rotating the light emitting section about a vertically extending shaft and a vertically changing section for rotating the light emitting section about a transversely extending shaft, and moves a light beam as a spotlight on a floor surface to guide a pet.

摘要翻译： 光学宠物引导装置设置有用于沿特定方向发射光束的发光部分，用于沿二维方向改变发光部分的朝向的方向改变部分，以及用于使方向改变部分 以改变发光部的朝向的方向。 方向改变部分包括用于围绕垂直延伸的轴旋转发光部分的横向变化部分和用于使发光部分围绕横向延伸的轴旋转的垂直变化部分，并将作为聚光灯的光束移动到地板表面上， 引导宠物

公开(公告)号：US07001272B2

公开(公告)日：2006-02-21

申请号：US10106259

申请日：2002-03-27

申请人： Akihisa Yamashita ,  Masato Nagatomi ,  Kenichi Yamamoto ,  Hideki Kotani

发明人： Akihisa Yamashita ,  Masato Nagatomi ,  Kenichi Yamamoto ,  Hideki Kotani

IPC分类号： A63F13/00

CPC分类号： A63F13/245 ,  A63F13/06 ,  A63F13/08 ,  A63F13/213 ,  A63F13/42 ,  A63F13/58 ,  A63F13/833 ,  A63F2300/1012 ,  A63F2300/1037 ,  A63F2300/1087 ,  A63F2300/65 ,  A63F2300/8029

摘要： A game system that allows a player to manipulate a real interface device in a real space and have a representation of the real interface device (i.e., a virtual interface device) be displayed in a virtual space is disclosed. The position of the real interface device in the real space is detected by a position detector and converted into spatial coordinates by a three-dimensional input conversion means at predetermined time intervals. When a player moves the real interface device, a virtual interface device is displayed within the virtual space and moves identically with the real interface device. The virtual interface device is determined to have struck an object in the virtual space (e.g., an enemy) when the coordinates of at least a portion of the object in the virtual space are the same as, or within a predetermined range of, the coordinates of the virtual interface device.

公开(公告)号：USD463501S1

公开(公告)日：2002-09-24

申请号：US29148973

申请日：2001-09-28

申请人： Yoshitsugu Isetani ,  Akihisa Yamashita ,  Hideki Kotani

设计人： Yoshitsugu Isetani ,  Akihisa Yamashita ,  Hideki Kotani

公开(公告)号：US06276682B1

公开(公告)日：2001-08-21

申请号：US09488116

申请日：2000-01-20

申请人： Akihisa Yamashita ,  Kojiro Minami ,  Eita Kada ,  Hideki Kotani ,  Yusuke Fujimoto ,  Hajime Dohki

发明人： Akihisa Yamashita ,  Kojiro Minami ,  Eita Kada ,  Hideki Kotani ,  Yusuke Fujimoto ,  Hajime Dohki

IPC分类号： A63F700

CPC分类号： A63F7/3603 ,  A63F5/00 ,  A63F7/0632

摘要： An air hockey game apparatus provides appropriate dynamic characteristics to the game, thereby effectively improving amusement characteristics of the game. The air hockey game apparatus has a puck sliding surface having blowholes for blowing air to float a puck, an air-blower for blowing and sending air toward blowholes, a puck-reflecting frame around the puck sliding surface, goals on the puck sliding surface, blocking members in the individual goals, opening/closing driving units for changing the open sizes of the individual goals by using the blocking members, and a controller for controlling the opening/closing driving units, thereby allowing competition for entering the puck into the goals.

摘要翻译： 空中曲棍球游戏装置为游戏提供适当的动态特征，从而有效地改善游戏的娱乐特性。 空气曲棍球游戏装置具有：具有用于吹动空气以浮起圆盘的气泡的圆盘滑动表面，用于吹送和吹送空气的鼓风机，围绕冰球滑动表面的圆盘反射框架，圆盘滑动表面上的目标， 各个目标中的阻挡构件，通过使用阻挡构件改变各个目标的开放尺寸的打开/关闭驱动单元，以及用于控制打开/关闭驱动单元的控制器，从而允许将冰球进入目标的竞争。