公开(公告)号：US06974597B2

公开(公告)日：2005-12-13

申请号：US09890217

申请日：2000-11-29

申请人： Shigenori Ohta ,  Chiaki Saitoh ,  Hiroaki Iwasaki ,  Aki Morita

发明人： Shigenori Ohta ,  Chiaki Saitoh ,  Hiroaki Iwasaki ,  Aki Morita

IPC分类号： A23L27/00 ,  A23L23/00 ,  A23L27/21 ,  A23L27/40 ,  A23L27/50 ,  A23L2/00 ,  A23L1/237 ,  A22L1/227

CPC分类号： A23L23/00 ,  A23L27/21 ,  A23L27/40 ,  A23L27/50

摘要： The present invention relates to a method of enhancing the salty taste of a food or beverage containing salt which comprises adding an acidic peptide or a peptide obtained by subjecting a protein to hydrolysis and deamidation to the food or beverage, a salty taste enhancer comprising the peptide as an active ingredient, a salty taste seasoning agent comprising the peptide and salt, and a food or beverage comprising the salty taste enhancer or the salty taste seasoning agent.

摘要翻译： 本发明涉及一种增加含有食品或饮料的咸味的方法，该方法包括加入通过使蛋白质对食品或饮料进行水解和脱酰胺而获得的酸性肽或肽，包含该肽的咸味增强剂 作为活性成分，包含肽和盐的咸味调味剂和包含咸味增强剂或咸味调味剂的食品或饮料。

公开(公告)号：US20080312435A1

公开(公告)日：2008-12-18

申请号：US11667728

申请日：2005-10-31

申请人： Shiuji Saito ,  Hiroshi Ohta ,  Tomoko Ishizaki ,  Mitsukane Yoshinaga ,  Makoto Tatsuzuki ,  Yuji Yokobori ,  Yasumitsu Tomishima ,  Aki Morita ,  Yoshihisa Toda ,  Kimiko Tokugawa ,  Ayaka Kaku ,  Tomomi Murakami ,  Hiromitsu Yoshimura ,  Shingo Sekine ,  Takao Yoshimizu

发明人： Shiuji Saito ,  Hiroshi Ohta ,  Tomoko Ishizaki ,  Mitsukane Yoshinaga ,  Makoto Tatsuzuki ,  Yuji Yokobori ,  Yasumitsu Tomishima ,  Aki Morita ,  Yoshihisa Toda ,  Kimiko Tokugawa ,  Ayaka Kaku ,  Tomomi Murakami ,  Hiromitsu Yoshimura ,  Shingo Sekine ,  Takao Yoshimizu

IPC分类号： C07D417/12 ,  C07D213/75 ,  C07D277/46 ,  C07D231/40 ,  C07D263/48

CPC分类号： C07D417/12 ,  C07D213/75 ,  C07D231/40 ,  C07D401/12 ,  C07D409/12 ,  C07D413/12

摘要： An imine compound represented by the formula: wherein A represents a heterocyclic group; R1, R2, an R3 each represent a hydrogen atom, a halogen atom, a C1-10 alkyl group optionally substituted with an aryl group(s) substituted with a halogen atom(s), a C3-10 cycloalkyl group, a C1-6 haloalkyl group, a C1-10 alkoxy group, etc.; R4 represents an optionally substituted C1-10 alkyl, C2-6 alkenyl, or aryl group; R5 represents a hydrogen atom, a C1-10 alkoxy group, a C1-6 haloalkyl group, an optionally substituted C1-10 alkyl or C2-6 alkenyl group, an optionally substituted aryl or heterocyclic group, etc.; W represents —CO—, —CO—CO—, —CO—NH—, —CS—NH—, or —SO2—, or a cannabinoid-receptor agonist comprising said imine compound as an active ingredient. The imine compound of the present invention has a cannabinoid-receptor agonist effect, and is useful as a therapeutic or prophylactic drug for pains and autoimmune diseases.

摘要翻译： 由下式表示的亚胺化合物：其中A表示杂环基; R 1，R 2，R 3各自表示氢原子，卤素原子，任选被被卤素原子取代的芳基取代的C 1-10烷基，C 3-10环烷基， 6卤代烷基，C1-10烷氧基等; R 4表示任选取代的C 1-10烷基，C 2-6烯基或芳基; R5表示氢原子，C1-10烷氧基，C1-6卤代烷基，任选取代的C 1-10烷基或C 2-6烯基，任选取代的芳基或杂环基等; W表示-CO-，-CO-CO-，-CO-NH-，-CS-NH-或-SO 2 - 或包含所述亚胺化合物作为活性成分的大麻素受体激动剂。 本发明的亚胺化合物具有大麻素受体激动剂作用，可用作疼痛和自身免疫疾病的治疗或预防药物。