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1.发明申请Transgenic animal having an amyloid precursor protein with a modified beta secretase cleavage site 失效具有具有改良的β分泌酶切割位点的淀粉样蛋白前体蛋白质的转基因动物公开(公告)号：US20070101449A1
公开(公告)日：2007-05-03
申请号：US10558656
申请日：2004-05-28
申请人： Richard Chen , Adam Simon , Thomas Vogt
发明人： Richard Chen , Adam Simon , Thomas Vogt
IPC分类号： A01K67/027 , C12N5/06
CPC分类号： C07K14/4711 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2267/0312 , C07K16/18 , C12N15/8509 , C12N2800/30
摘要： The present invention provides transgenic animals having an amyloid precursor protein wherein the amino acids flanking the &bgr; secretase cleavage site are NF and EV. The invention also provides tissues and cell lines derived from such animals. The invention further provides methods of screening candidate compounds to determine whether the compounds can alter the rate of cleavage of amyloid precursor protein by &bgr; secretase.
摘要翻译： 本发明提供具有淀粉样前体蛋白质的转基因动物，其中β分泌酶切割位点侧翼的氨基酸为NF和EV。 本发明还提供了衍生自这些动物的组织和细胞系。 本发明进一步提供筛选候选化合物以确定化合物是否可以通过β分泌酶改变淀粉样蛋白前体蛋白的切割速率的方法。
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公开(公告)号：US20120221200A1
公开(公告)日：2012-08-30
申请号：US13465468
申请日：2012-05-07
申请人： ADAM SIMON GOLOMB
发明人： ADAM SIMON GOLOMB
IPC分类号： G06F17/00
CPC分类号： B62D1/046 , B60Q1/0082 , B60Q1/343 , Y10T74/20834
摘要： The present invention provides a system which integrates motor vehicle component operation into actuators located in the rim of a motor vehicle steering wheel. The two actuators of the system of the present invention are located in an arc segment of the steering wheel defined by the three o'clock and 12 o'clock positions for the right-hand actuator and the nine o'clock and 12 o'clock positions for the left-hand actuator. The actuators may operate in parallel with a conventional stalk switch or controls associated with an on board computer and only operate a motor vehicle component when activated and subsequently depressed. The integrated vehicle control system and apparatus of the present invention further provides for vehicle component operation which does not require a driver to remove his or her hands from the steering wheel.
摘要翻译： 本发明提供一种将机动车辆部件操作集成到位于机动车辆方向盘的轮辋内的致动器的系统。 本发明系统的两个致动器位于由用于右侧致动器的三点钟和十二点钟位置定义的方向盘的弧段中，并且在九点钟和十二点钟 左侧执行器的位置。 致动器可以与常规的杆开关或与板上计算机相关联的控制器并联操作，并且仅在被激活并随后被压下时才操作机动车辆部件。 本发明的集成车辆控制系统和装置进一步提供车辆部件操作，其不需要驾驶员从方向盘移除他或她的手。
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公开(公告)号：US20110057785A1
公开(公告)日：2011-03-10
申请号：US12555477
申请日：2009-09-08
申请人： Adam Simon Golomb
发明人： Adam Simon Golomb
IPC分类号： B60Q1/34
CPC分类号： B60Q1/343 , B60Q1/0082 , B62D1/046
摘要： The present provides a system which integrates motor vehicle turn signal operation into actuators located in the rim of a motor vehicle steering wheel. The actuators of the system of the present invention, one for controlling the right-hand turn signal and one for controlling the left-hand turn signal, are located in an arc segment of the steering wheel defined by the three o'clock and 12 o'clock positions for the right-hand actuator and the nine o'clock and 12 o'clock positions for the left-hand actuator. The actuators may operate in parallel with a conventional stalk switch and only turn on the respective turn signal lights when activated and subsequently depressed. The turn signal lights turn off when the actuators are released. The integrated turn signal system of the present invention further provides for turn signal operation which does not require a driver to remove his or her hands from the steering wheel.
摘要翻译： 本发明提供了一种将机动车转向信号操作集成到位于机动车辆方向盘的轮辋内的致动器的系统。 用于控制右转转信号的本发明系统的致动器和用于控制左转转信号的致动器位于由三点和12点定义的方向盘的弧段中 “右手执行器的时钟位置和左手执行器的九点钟和十二点钟位置。 致动器可以与常规的杆开关并联操作，并且仅在被激活并随后被压下时才打开相应的转向灯信号灯。 当执行器被释放时，转向信号灯熄灭。 本发明的集成转向信号系统进一步提供转向信号操作，其不需要驾驶员从方向盘移除他或她的手。
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4.发明申请Amide surfactant thickening systems for hair colouring and bleaching compositions 审中-公开用于染发和漂白组合物的酰胺表面活性剂增稠体系公开(公告)号：US20070251029A1
公开(公告)日：2007-11-01
申请号：US11789451
申请日：2007-04-24
IPC分类号： A61K8/00
摘要： The present invention relates to hair colouring and hair bleaching compositions comprising a source of carbonate ions, at least one oxidizing agent and a specified amide surfactant. The compositions surprisingly provide improved hair colourant and bleaching compositions which deliver improved lift, lightening and colour delivery whilst minimizing damage which are easy to manufacture and have long shelf life stability.
摘要翻译： 本发明涉及包含碳酸根离子源，至少一种氧化剂和特定酰胺表面活性剂的毛发着色和毛发漂白组合物。 该组合物惊人地提供改进的头发着色剂和漂白组合物，其提供改善的提升，减轻和着色传递，同时最小化容易制造并具有长保质期稳定性的损伤。
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5.发明申请公开(公告)号：US20070219354A1
公开(公告)日：2007-09-20
申请号：US11714985
申请日：2007-03-07
申请人： Daria Hazuda , Elizabeth Chen Dodson , Ming-Tain Lai , Min Xu , Xiao-Ping Shi , Adam Simon , Guoxin Wu , Yueming Li , Bruce Register
发明人： Daria Hazuda , Elizabeth Chen Dodson , Ming-Tain Lai , Min Xu , Xiao-Ping Shi , Adam Simon , Guoxin Wu , Yueming Li , Bruce Register
CPC分类号： C07K7/06 , A01K2217/05 , A01K2267/0306 , A61K38/00 , C07K5/1016 , C07K5/1019 , C07K5/1021 , C07K14/4711 , C07K16/18 , C12P21/06 , C12Q1/37 , G01N33/5088 , G01N33/6896 , G01N2500/00 , G01N2800/52
摘要： Provided are methods of identifying inhibitors of β-secretase that employ modified β-secretase substrates. The modified β-secretase substrates have β-secretase cleavage sites that are altered from wild type. The amino acid sequences of the altered β-secretase cleavage sites contain different amino acids in at least one of the positions P2-P1-P1′-P2′ of the β-secretase cleavage site. Many of the modified β-secretase substrates are more efficient substrates for β-secretase than are corresponding substrates having wild-type sequences, that is, these modified substrates are more susceptible to enzymatic breakdown by β-secretase. Recombinant polynucleotide molecules encoding the modified β-secretase substrates are provided. Antibodies that recognize cleavage products of the modified β-secretase substrates are provided. Stable cell lines expressing the modified β-secretase substrates are provided. Transgenic animals expressing the modified β-secretase substrates are provided.
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6.发明申请Assays and methods to detect beta-secretase and its activity in body fluids and tissue extracts 审中-公开检测β-分泌酶及其在体液和组织提取物中的活性的测定和方法公开(公告)号：US20070292895A1
公开(公告)日：2007-12-20
申请号：US11803207
申请日：2007-05-14
申请人： Xiao-Ping Shi , Guoxin Wu , Jason Kahana , Adam Simon
发明人： Xiao-Ping Shi , Guoxin Wu , Jason Kahana , Adam Simon
IPC分类号： G01N33/573
CPC分类号： G01N33/6896 , G01N2333/948 , G01N2800/2821 , G01N2800/52
摘要： Methods and assays for detecting β-secretase (BACE-1) activity in body fluids or tissue extracts from individuals, particularly individuals who have Alzheimer's disease, are disclosed. A truncated form of BACE-1 was isolated that can be used as a biomarker for Alzheimer's disease.
摘要翻译： 公开了用于检测来自个体，特别是患有阿尔茨海默病的个体的体液或组织提取物中的β-分泌酶（BACE-1）活性的方法和测定法。 分离出截短形式的BACE-1，其可用作阿尔茨海默病的生物标志物。
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公开(公告)号：US20060270841A1
公开(公告)日：2006-11-30
申请号：US10504446
申请日：2003-02-25
申请人： Amy Espeseth , Marc Ferrer , Osvaldo Flores , Daria Hazuda , James Inglese , Michael Miller , Bruce Register , Xiao-Ping Shi , Adam Simon , Paul Zuck
发明人： Amy Espeseth , Marc Ferrer , Osvaldo Flores , Daria Hazuda , James Inglese , Michael Miller , Bruce Register , Xiao-Ping Shi , Adam Simon , Paul Zuck
CPC分类号： C07K14/47 , C07K14/4702 , C07K14/4711 , C07K2319/00 , C07K2319/50 , G01N2500/10
摘要： The present invention provides DNA constructs, genetically engineered host cells, and methods for identifying inhibitors of amyloid precursor protein (APP) processing. The methods provide for the convenient identification, in a single assay, of inhibitors of β-secretase and γ-secretase as well as other forms of APP processing. The methods rely on fusion proteins of APP and transcription factors in which APP processing releases the transcription factors, allowing the transcription factors to activate transcription of a reporter gene. Inhibitors are identified as substances that block or diminish transcription factor release from the fusion protein, thereby causing a diminution of reporter gene readout.
摘要翻译： 本发明提供了DNA构建体，遗传工程化宿主细胞和用于鉴定淀粉样前体蛋白（APP）处理抑制剂的方法。 该方法提供了在单次测定中方便地鉴定β-分泌酶和γ-分泌酶抑制剂以及其它形式的APP处理。 该方法依赖于APP和转录因子的融合蛋白，其中APP处理释放转录因子，允许转录因子激活报告基因的转录。 抑制剂被鉴定为阻断或减少转录因子从融合蛋白释放的物质，从而导致报告基因读出的减少。
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公开(公告)号：US20140261007A1
公开(公告)日：2014-09-18
申请号：US14211442
申请日：2014-03-14
申请人： Adam Simon Golomb
发明人： Adam Simon Golomb
CPC分类号： F24C3/124 , F23D14/72 , F23N5/082 , F23N5/242 , F23N2023/54 , F23N2029/20 , F23N2031/00 , F23N2041/08 , F24C3/122 , F24C3/126
摘要： A gas burner safety system comprises dual sensor arrays, the first array positioned proximal to the gas burner and the second array positioned proximal to a control used to turn on and of and regulate the flame of the gas burner. The first array senses the flame components such that a flame signature is obtained when no object is placed on or above the flame and a flame image is obtained when an object is proximal to the flame. By comparing the flame signature and the flame image, a central control unit operatively connected to the sensor arrays can determine the presence or absence of an object proximal to the flame. The second sensor array is positioned to detect a human hand proximal to the control. In operation, if the flame image matches the flame signature and a human hand is not detected proximal to the control, the central control unit turns off the gas burner by causing the closure of a valve in the gas supply line to the gas burner.
摘要翻译： 气体燃烧器安全系统包括双传感器阵列，第一阵列靠近气体燃烧器定位，第二阵列位于靠近用于打开和调节气体燃烧器的火焰的控制器附近。 第一阵列感测火焰部件，使得当没有物体放置在火焰上或火焰上时获得火焰特征，并且当物体靠近火焰时获得火焰图像。 通过比较火焰特征和火焰图像，可操作地连接到传感器阵列的中央控制单元可以确定靠近火焰的物体的存在或不存在。 第二传感器阵列被定位成检测靠近控制器的人手。 在操作中，如果火焰图像与火焰特征匹配并且靠近控制点未检测到人手，则中央控制单元通过使燃气燃烧器的气体供应管线中的阀关闭来关闭气体燃烧器。
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公开(公告)号：US08446265B2
公开(公告)日：2013-05-21
申请号：US13465468
申请日：2012-05-07
申请人： Adam Simon Golomb
发明人： Adam Simon Golomb
IPC分类号： B60Q1/00
CPC分类号： B62D1/046 , B60Q1/0082 , B60Q1/343 , Y10T74/20834
摘要： The present invention provides a system which integrates motor vehicle component operation into actuators located in the rim of a motor vehicle steering wheel. The two actuators of the system of the present invention are located in an arc segment of the steering wheel defined by the three o'clock and 12 o'clock positions for the right-hand actuator and the nine o'clock and 12 o'clock positions for the left-hand actuator. The actuators may operate in parallel with a conventional stalk switch or controls associated with an on board computer and only operate a motor vehicle component when activated and subsequently depressed. The integrated vehicle control system and apparatus of the present invention further provides for vehicle component operation which does not require a driver to remove his or her hands from the steering wheel.
摘要翻译： 本发明提供一种将机动车辆部件操作集成到位于机动车辆方向盘的轮辋内的致动器的系统。 本发明系统的两个致动器位于由用于右侧致动器的三点钟和十二点钟位置定义的方向盘的弧段中，并且在九点钟和十二点钟 左侧执行器的位置。 致动器可以与常规的杆开关或与板上计算机相关联的控制器并联操作，并且仅在被激活并随后被压下时才操作机动车辆部件。 本发明的集成车辆控制系统和装置进一步提供车辆部件操作，其不需要驾驶员从方向盘移除他或她的手。
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公开(公告)号：US08198996B2
公开(公告)日：2012-06-12
申请号：US12555477
申请日：2009-09-08
申请人： Adam Simon Golomb
发明人： Adam Simon Golomb
IPC分类号： B60Q1/34
CPC分类号： B60Q1/343 , B60Q1/0082 , B62D1/046
摘要： The present provides a system which integrates motor vehicle turn signal operation into actuators located in the rim of a motor vehicle steering wheel. The actuators of the system of the present invention, one for controlling the right-hand turn signal and one for controlling the left-hand turn signal, are located in an arc segment of the steering wheel defined by the three o'clock and 12 o'clock positions for the right-hand actuator and the nine o'clock and 12 o'clock positions for the left-hand actuator. The actuators may operate in parallel with a conventional stalk switch and only turn on the respective turn signal lights when activated and subsequently depressed. The turn signal lights turn off when the actuators are released. The integrated turn signal system of the present invention further provides for turn signal operation which does not require a driver to remove his or her hands from the steering wheel.
摘要翻译： 本发明提供了一种将机动车转向信号操作集成到位于机动车辆方向盘的轮辋内的致动器的系统。 用于控制右转转信号的本发明系统的致动器和用于控制左转转信号的致动器位于由三点和12点定义的方向盘的弧段中 “右手执行器的时钟位置和左手执行器的九点钟和十二点钟位置。 致动器可以与常规的杆开关并联操作，并且仅在被激活并随后被压下时才打开相应的转向灯信号灯。 当执行器被释放时，转向信号灯熄灭。 本发明的集成转向信号系统进一步提供转向信号操作，其不需要驾驶员从方向盘移除他或她的手。
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