公开(公告)号：US20240043503A1

公开(公告)日：2024-02-08

申请号：US18378021

申请日：2023-10-09

申请人： ADMA BIOMANUFACTURING, LLC

发明人： Adam S. Grossman ,  James Mond ,  Jerrold B. Grossman ,  Dov A. Goldstein

IPC分类号： C07K16/06 ,  A61K39/395 ,  A61K39/42 ,  C07K16/08 ,  C07K16/10 ,  A61K39/155 ,  A61K45/06 ,  G01N33/68 ,  C07K16/12

CPC分类号： C07K16/06 ,  A61K39/39516 ,  A61K39/42 ,  C07K16/08 ,  C07K16/1027 ,  A61K39/155 ,  A61K45/06 ,  C07K16/10 ,  G01N33/6854 ,  C07K16/1009 ,  C07K16/1203 ,  C07K16/1232 ,  C07K16/1242 ,  C07K16/1271 ,  C07K16/1275 ,  C07K16/1282 ,  C07K16/1285 ,  C07K16/1289 ,  A61K2039/507

摘要： The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).

公开(公告)号：US20240262896A1

公开(公告)日：2024-08-08

申请号：US18438693

申请日：2024-02-12

申请人： ADMA BIOMANUFACTURING, LLC

发明人： James Mond ,  Adam S. Grossman

IPC分类号： C07K16/12 ,  A61K9/00 ,  A61K35/16 ,  C07K16/06

CPC分类号： C07K16/1275 ,  A61K9/0019 ,  A61K35/16 ,  C07K16/06 ,  C07K16/065 ,  C07K2317/10 ,  C07K2317/21

摘要： The present invention relates to compositions and methods for the treatment of infection caused by Streptococcus pneumonia. In particular, the invention provides human hyperimmune globulin and compositions thereof for preventing or treating pneumococcal infection. The invention provides methods of producing hyperimmune globulin containing high titers of opsonophagocytic anti-pneumococcal antibodies, compositions containing same, and methods of using the compositions for the prevention and treatment of pneumococcal infection. The invention further provides methods of preventing or treating pneumococcal infection (e.g., upper respiratory infections (e.g., bronchitis, otitis, sinusitis, etc.)) in immunocompromised subjects via administration of hyperimmune globulin compositions of the invention (e.g., containing a high titer of opsonophagocytic anti-pneumococcal antibodies) to immunocompromised subjects.