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公开(公告)号：US20240085425A1
公开(公告)日：2024-03-14
申请号：US18235523
申请日：2023-08-18
发明人： Nanhai HE , Youping WANG , Zhihong LIU , Yufeng CHEN
IPC分类号： G01N33/574 , A61K31/519 , A61P35/00
CPC分类号： G01N33/57484 , A61K31/519 , A61P35/00 , G01N2474/20
摘要： The present disclosure provides an application of non-phosphorylated β-catenin protein in tumor cells as a biomarker for predicting the responsivity or sensitivity of tumor cells to wnt pathway inhibitors, a method of using non-phosphorylated β-catenin protein in tumor cells as a biomarker to predict the responsivity or sensitivity of tumor cells to wnt pathway inhibitors, a method for treating tumor patients, a method for detecting the content of non-phosphorylated β-catenin in tumor tissues or tumor cells, and a suitable wnt inhibitor.
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公开(公告)号：US20200331887A1
公开(公告)日：2020-10-22
申请号：US16914142
申请日：2020-06-26
发明人： Pan LI , Qiaodong WEN , Ji WANG , Quan GAN , Yang LU , Donghui YANG
IPC分类号： C07D401/12 , C07D215/14 , C07D409/12 , C07D401/08 , C07D405/08
摘要： The present invention relates to a compound represented by formula I, a pharmaceutical composition containing the compound of formula I, a method for inhibiting indoleamine 2,3-dioxygenase, and its use in medicine.
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公开(公告)号：US20240287093A1
公开(公告)日：2024-08-29
申请号：US17268613
申请日：2019-08-21
发明人： Yufeng CHEN , Kaixuan CHEN , Pan LI , Canfeng LIU , Ji WANG , Qingchong QIU , Yang LU
IPC分类号： C07D498/06 , A61K31/4985 , A61K31/5383 , A61K31/5517 , A61K31/553 , A61K45/06 , C07D487/06
CPC分类号： C07D498/06 , A61K31/4985 , A61K31/5383 , A61K31/5517 , A61K31/553 , A61K45/06 , C07D487/06
摘要： The present disclosure provides compounds of Formula (I), pharmaceutical compositions thereof, and methods of using compounds of Formula (I) to prevent and/or treat immune-related disorders.
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公开(公告)号：US20230399327A1
公开(公告)日：2023-12-14
申请号：US18034367
申请日：2021-10-26
发明人： Yufeng CHEN , Canfeng LIU , Meng LV , Qiaodong WEN , Yongqiang SHI , Peng WU , Kaixuan CHEN , Han YANG , Wanli CHENG , Youping WANG , Pingping LU , Nanhai HE
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： A compound of formula (I) having the activity of inhibiting HPK1 kinase and a pharmaceutical composition comprising the compound. Also provided are the use of the compound in the prevention and/or treatment of cancers, tumors, inflammatory diseases, autoimmune diseases or immune-mediated diseases.
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公开(公告)号：US20230054028A1
公开(公告)日：2023-02-23
申请号：US17780979
申请日：2020-12-22
发明人： Zhiyong YU , Pan LI , Beidi XU , Yu ZHOU , Wei PANG , Qiaodong WEN , Yongqiang SHI , Zhao SUN , Meng LV
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D405/14 , C07D403/14 , C07D403/10
摘要： Provided are a compound of Formula (I) and a pharmaceutical composition thereof, as well as a method for using the compounds of Formula (I) to prevent and/or treat immune-related disorders.
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公开(公告)号：US12091398B2
公开(公告)日：2024-09-17
申请号：US17281251
申请日：2020-02-20
发明人： Pan Li , Beidi Xu , Qiaodong Wen , Enguang Feng , Ji Wang , Yang Lu , Yu Zhou , Zhiyong Yu , Zhiying Huang
IPC分类号： C07D401/14 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/14 , C07D471/04 , C07D471/10
CPC分类号： C07D401/14 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/14 , C07D471/04 , C07D471/10
摘要： Provided is a compound represented by formula (I) and a pharmaceutical composition thereof, as well as a method for using a compound represented by formula (I) to prevent and/or treat immune-related disorders.
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公开(公告)号：US20240189320A1
公开(公告)日：2024-06-13
申请号：US17270480
申请日：2019-08-22
发明人： Yufeng CHEN , Kaixuan CHEN , Pan LI , Canfeng LIU , Ji WANG , Qingchong QIU , Yang LU
IPC分类号： A61K31/5386 , A61K31/437 , A61K31/4985 , A61K31/5383 , A61K31/551 , A61K31/553 , A61P35/00 , C07D471/06 , C07D487/06 , C07D498/06 , C07D498/22 , C07D519/00
CPC分类号： A61K31/5386 , A61K31/437 , A61K31/4985 , A61K31/5383 , A61K31/551 , A61K31/553 , A61P35/00 , C07D471/06 , C07D487/06 , C07D498/06 , C07D498/22 , C07D519/00
摘要： The present invention provides compounds of Formula (I) or (II), pharmaceutical compositions thereof, and methods of using compounds of Formula (I) or (II) to prevent and/or treat immune-related disorders.
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公开(公告)号：US11680271B2
公开(公告)日：2023-06-20
申请号：US17321603
申请日：2021-05-17
发明人： Nanhai He , Dandan Chen , Yang Lu , Donghui Yang
CPC分类号： C12N15/81 , C12N15/1037 , C40B40/08 , C12N2800/102
摘要： The present disclosure application relates to a construction method of a yeast display library (YSD), specifically to a construct for a yeast display library, an expression vector, a host cell and a construction method and use thereof. The yeast display library provided by the present application has high transformation efficiency and rich diversity.
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公开(公告)号：US11111230B2
公开(公告)日：2021-09-07
申请号：US16914142
申请日：2020-06-26
发明人： Pan Li , Qiaodong Wen , Ji Wang , Quan Gan , Yang Lu , Donghui Yang
IPC分类号： C07D215/14 , C07D401/12 , C07D401/08 , C07D405/08 , C07D409/12
摘要： The present invention relates to a compound represented by formula I, a pharmaceutical composition containing the compound of formula I, a method for inhibiting indoleamine 2,3-dioxygenase, and its use in medicine.
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公开(公告)号：US11965875B2
公开(公告)日：2024-04-23
申请号：US17323078
申请日：2021-05-18
发明人： Nanhai He , Youping Wang , Yang Lu , Donghui Yang
CPC分类号： G01N33/5011 , G01N33/505 , G01N33/5052
摘要： The present application relates to a system and a method for effectively screening and assessing agents for tumor immunotherapy, which includes assessment for the effects of target cells, non-target cells, and tumor infiltration. The system and method of the present application can be used to comprehensively and systematically assess the effectiveness and safety of the agent against tumor immune cells.
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