公开(公告)号：US12006369B2

公开(公告)日：2024-06-11

申请号：US16515870

申请日：2019-07-18

Applicant: 2seventy bio, Inc.

Inventor： Richard Morgan ,  Kevin Friedman

IPC: C07K16/28 ,  A61K38/17 ,  A61K39/395 ,  C07K14/705 ,  C07K14/725 ,  C12N15/86 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61K38/177 ,  A61K38/1774 ,  A61K39/3955 ,  C07K14/70503 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70578 ,  C12N15/86 ,  A61K2039/5156 ,  A61K2039/572 ,  C07K2317/24 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/10 ,  C07K2319/33 ,  C12N2740/15043 ,  C12N2830/48 ,  C12N2830/50 ,  C12N2830/60

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

公开(公告)号：US11952413B2

公开(公告)日：2024-04-09

申请号：US16771402

申请日：2018-12-14

Applicant: 2seventy bio, Inc.

Inventor： Wai-Hang Leung

IPC: C07K14/54 ,  A61K35/17 ,  A61K38/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/715 ,  C07K14/73

CPC classification number: C07K14/7155 ,  A61K35/17 ,  A61K38/00 ,  A61P35/00 ,  C07K14/70514 ,  C07K14/70517 ,  C07K14/70575 ,  C07K2319/70

Abstract: The present disclosure provides improved compositions for adoptive T cell therapies for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.

公开(公告)号：US11779654B2

公开(公告)日：2023-10-10

申请号：US16753117

申请日：2018-10-04

Applicant: 2seventy bio, Inc.

Inventor： Jordan Jarjour ,  Kyle Havens ,  Michael Certo ,  Max Echterling

IPC: A61K48/00 ,  A61P3/06 ,  C12N9/22 ,  C12N9/64 ,  C12N15/63 ,  C12N15/90

CPC classification number: A61K48/005 ,  A61K48/0041 ,  A61P3/06 ,  C12N9/22 ,  C12N9/6454 ,  C12N15/63 ,  C12N15/90 ,  C12Y304/21061

Abstract: The present disclosure provides improved genome editing compositions and methods for editing a PCSK9 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of hypercholesterolemia or a condition associated therewith.

公开(公告)号：US11479755B2

公开(公告)日：2022-10-25

申请号：US16060184

申请日：2015-12-07

Applicant: 2seventy bio, Inc.

Inventor： Kevin Friedman

IPC: C12N5/0783 ,  A61K35/17 ,  C07K14/705 ,  C12N15/86 ,  A61K35/00 ,  A61K39/00 ,  A61P35/02

Abstract: The invention provides improved T cell compositions and methods for manufacturing T cells. More particularly, the invention provides methods of T cell manufacturing that result in adoptive T cell immunotherapies with improved survival, expansion, and persistence in vivo.

公开(公告)号：US20220280567A1

公开(公告)日：2022-09-08

申请号：US17618747

申请日：2020-06-11

Applicant: 2seventy bio, Inc.

Inventor： KEVIN FRIEDMAN

IPC: A61K35/17 ,  C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  C07K14/005 ,  A61P35/00

Abstract: The invention provides improved compositions for adoptive cell therapies for cancers that express CD79A and/or CD20.

公开(公告)号：US11365226B2

公开(公告)日：2022-06-21

申请号：US16330039

申请日：2017-09-08

Applicant: 2seventy bio, Inc.

Inventor： Jasdeep Mann ,  Joel Gay ,  Jordan Jarjour ,  Joy Zhang

IPC: C07K14/47 ,  C12N15/86

Abstract: The present disclosure provides improved genome editing compositions and methods for editing a PD-1 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.

公开(公告)号：US20220119784A1

公开(公告)日：2022-04-21

申请号：US17311464

申请日：2019-12-09

Applicant: 2seventy bio, Inc.

Inventor： JORDAN JARJOUR ,  KYLE HAVENS ,  CONSTANTINE CHRYSOSTOMOU

IPC: C12N9/22

Abstract: The present disclosure provides homing endonuclease variants and megaTALs reprogrammed to bind and cleave a polynucleotide sequence in the genome. The homing endonuclease variants and megaTALs have been engineered to increase the thermostability and/or activity.

公开(公告)号：US20250064722A1

公开(公告)日：2025-02-27

申请号：US18820674

申请日：2024-08-30

Applicant: 2seventy bio, Inc.

Inventor： Travis Quigley ,  Robert Ross

IPC: A61K9/00 ,  A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28

Abstract: The invention provides improved anti-BCMA CAR T cell compositions for adoptive T cell therapy for relapsed/refractory multiple myeloma.

公开(公告)号：US20250026845A1

公开(公告)日：2025-01-23

申请号：US18736997

申请日：2024-06-07

Applicant: 2seventy bio, Inc.

Inventor： Richard Morgan ,  Kevin Friedman

IPC: C07K16/28 ,  A61K39/00 ,  C07K14/705 ,  C07K14/725 ,  C12N5/0783 ,  C12N15/86

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

公开(公告)号：US20240336904A1

公开(公告)日：2024-10-10

申请号：US18258021

申请日：2021-12-16

Applicant: 2seventy bio, Inc.

Inventor： JORDAN JARJOUR ,  ANNE-RACHEL KROSTAG

IPC: C12N9/22 ,  A61K35/17 ,  C12N5/0783 ,  C12N15/10

CPC classification number: C12N9/22 ,  A61K35/17 ,  C12N5/0636 ,  C12N15/102 ,  C07K2319/81 ,  C12N2510/00 ,  C12Y301/11001 ,  C12Y301/11002

Abstract: The present disclosure provides improved genome editing compositions and methods for editing a double-strand DNA target site. The disclosure further provides genome edited cells produced by the compositions and methods described.