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公开(公告)号：US11970711B2
公开(公告)日：2024-04-30
申请号：US17481063
申请日：2021-09-21
IPC分类号： C12N15/11 , A01H6/46 , A01K67/027 , A61K38/46 , C12N9/22 , C12N15/10 , C12N15/113 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/90 , C12Q1/686 , H01L21/02 , H01L33/00 , A61K48/00
CPC分类号： C12N15/907 , A01H6/4684 , A01K67/027 , A61K38/465 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/113 , C12N15/63 , C12N15/70 , C12N15/746 , C12N15/90 , C12N15/902 , C12Q1/686 , H01L21/02312 , H01L21/02365 , H01L33/0075 , A61K48/00 , C12N2310/11 , C12N2310/13 , C12N2310/14 , C12N2310/20 , C12N2310/31 , C12N2310/32 , C12N2310/33 , C12N2310/3519 , C12N2310/531 , C12N2800/80 , C12Y301/04
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US11479794B2
公开(公告)日：2022-10-25
申请号：US17703861
申请日：2022-03-24
IPC分类号： C12N15/11 , C12N15/63 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A01H6/46 , A61K48/00 , C12N15/90 , C12Q1/686 , A61K38/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US11332761B2
公开(公告)日：2022-05-17
申请号：US17481052
申请日：2021-09-21
IPC分类号： C12N15/11 , C12N15/63 , C12N9/22 , C12N15/90 , C12Q1/686 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20220119845A1
公开(公告)日：2022-04-21
申请号：US17514883
申请日：2021-10-29
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20220073952A1
公开(公告)日：2022-03-10
申请号：US17514893
申请日：2021-10-29
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20220010338A1
公开(公告)日：2022-01-13
申请号：US17481063
申请日：2021-09-21
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20210340575A1
公开(公告)日：2021-11-04
申请号：US17326805
申请日：2021-05-21
IPC分类号： C12N15/90 , A01H6/46 , C12N15/10 , C12N15/74 , C12N15/113 , A61K38/46 , A01K67/027 , C12Q1/686 , C12N15/11 , C12N9/22 , C12N15/70 , C12N15/63 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20210157443A1
公开(公告)日：2021-05-27
申请号：US17263354
申请日：2019-07-25
摘要： An optical device for controlling light and an optical touch sensing device are formed by direct laser writing in a transparent substrate to manufacture one or more optical waveguides therein.
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公开(公告)号：US11001863B2
公开(公告)日：2021-05-11
申请号：US17102050
申请日：2020-11-23
IPC分类号： C12N15/10 , A61K38/46 , C12N15/11 , C12N15/113 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/90 , C12Q1/686 , C12N9/22 , A01H6/46 , A01K67/027 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20210108231A1
公开(公告)日：2021-04-15
申请号：US17102059
申请日：2020-11-23
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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