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1.发明授权公开(公告)号：US08252758B2
公开(公告)日：2012-08-28
申请号：US12170148
申请日：2008-07-09
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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2.发明申请MODULATION OF 11 BETA-HYDROXYSTERIOD DEHYDROGENASE 1 EXPRESSION FOR THE TREATMENT OF OCULAR DISEASES 有权11个氢化脱氢酶脱氢酶1表达调控治疗眼部疾病公开(公告)号：US20110160277A1
公开(公告)日：2011-06-30
申请号：US12091498
申请日：2006-10-25
IPC分类号： A61K31/7088 , C07H21/02 , A61P27/02
CPC分类号： C12N15/1137 , C12N2310/14 , C12Y101/01146
摘要： The invention relates to siNA compositions and methods for the treatment of eye conditions wherein the siNA compound capable of inhibiting the expression of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1).
摘要翻译： 本发明涉及用于治疗眼睛病症的siNA组合物和方法，其中能够抑制11β-羟基类固醇脱氢酶（11β-HSD1）表达的siNA化合物。
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3.发明授权Methods and compositions for the treatment of eye disorders with increased intraocular pressure 有权用于治疗眼睛压力升高的眼部疾病的方法和组合物公开(公告)号：US07902169B2
公开(公告)日：2011-03-08
申请号：US12563530
申请日：2009-09-21
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
摘要翻译： 本发明涉及降低眼睛眼内压（IOP）的方法和组合物。 本发明的组合物包含短干扰核酸分子（siNA），包括但不限于减少与眼内液的产生或引流相关基因表达的siRNA。 本发明的组合物可用于制备用于治疗眼睛症状的药物，所述眼部病症显示增加的眼压，例如青光眼，感染，炎症，葡萄膜炎和糖尿病性视网膜病变。 本发明的方法包括向有需要的患者施用有效量的本发明的一种或多种siNA。
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4.发明授权Methods and compositions for the treatment of eye disorders with increased intraocular pressure 有权用于治疗眼睛压力升高的眼部疾病的方法和组合物公开(公告)号：US07592325B2
公开(公告)日：2009-09-22
申请号：US11360305
申请日：2006-02-22
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
摘要翻译： 本发明涉及降低眼睛眼内压（IOP）的方法和组合物。 本发明的组合物包含短干扰核酸分子（siNA），包括但不限于减少与眼内液的产生或引流相关基因表达的siRNA。 本发明的组合物可用于制备用于治疗眼睛症状的药物，所述眼部病症显示增加的眼压，例如青光眼，感染，炎症，葡萄膜炎和糖尿病性视网膜病变。 本发明的方法包括向有需要的患者施用有效量的本发明的一种或多种siNA。
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公开(公告)号：US08871729B2
公开(公告)日：2014-10-28
申请号：US12293230
申请日：2007-03-16
申请人： Angela Sesto Yague , Eduardo Gomez-Acebo Gullon , Ma Concepción Jiménez Gomez , Ana Isabel Jiménez Antón
发明人： Angela Sesto Yague , Eduardo Gomez-Acebo Gullon , Ma Concepción Jiménez Gomez , Ana Isabel Jiménez Antón
IPC分类号： A61K31/70 , C12N15/113 , C12Q1/68 , A61K39/00
CPC分类号： C12N15/113 , A61K2039/543 , C12N2310/14 , C12N2320/32
摘要： Methods and compositions for the treatment of pathologic conditions of the central nervous system (CNS) by means of intranasal administration of a composition that modulates, by means of RNA interference, the expression and/or activity of genes involved in above-mentioned conditions.
摘要翻译： 通过鼻内施用组合物来治疗中枢神经系统（CNS）的病理状况的方法和组合物，其通过RNA干扰调节参与上述病症的基因的表达和/或活性。
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6.发明授权公开(公告)号：US08247387B2
公开(公告)日：2012-08-21
申请号：US12170116
申请日：2008-07-09
IPC分类号： A61K31/70
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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公开(公告)号：US08067577B2
公开(公告)日：2011-11-29
申请号：US12871366
申请日：2010-08-30
CPC分类号： A61K31/7115 , A61K31/00 , Y02A50/486
摘要： Methods and compositions for the treatment of intestinal disorders, such as IBD and Crohn's disease, are disclosed. Preferred compositions include siNA. Also disclosed is a method of specifically targeting siNA to treat intestinal disorders by intrarectal administration of siNA compounds.
摘要翻译： 公开了用于治疗肠疾病如IBD和克罗恩病的方法和组合物。 优选的组合物包括siNA。 还公开了专门靶向siNA以通过直肠内施用siNA化合物治疗肠道疾病的方法。
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8.发明授权Treatment of eye disorders characterized by an elevated intraocular pressure by siRNAs 有权治疗以siRNA为特征的眼内压升高的眼部疾病公开(公告)号：US08030284B2
公开(公告)日：2011-10-04
申请号：US11574169
申请日：2005-08-23
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： Sequences and protocols for treatment of eye conditions by use of RNA interference are disclosed. Target genes are selected from those responsible for aqueous flow or aqueous outflow, while particularly preferred conditions to be treated include glaucoma and uveitis.
摘要翻译： 公开了通过使用RNA干扰治疗眼睛状况的序列和方案。 靶基因选自负责水流或水流出的那些，而待治疗的特别优选的病症包括青光眼和葡萄膜炎。
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9.发明申请公开(公告)号：US20100331394A1
公开(公告)日：2010-12-30
申请号：US12874928
申请日：2010-09-02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
摘要翻译： 本发明涉及降低眼睛眼内压（IOP）的方法和组合物。 本发明的组合物包含短干扰核酸分子（siNA），包括但不限于减少与眼内液的产生或引流相关基因表达的siRNA。 本发明的组合物可用于制备用于治疗眼睛症状的药物，所述眼部病症显示增加的眼压，例如青光眼，感染，炎症，葡萄膜炎和糖尿病性视网膜病变。 本发明的方法包括向有需要的患者施用有效量的本发明的一种或多种siNA。
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10.发明申请公开(公告)号：US20090099111A1
公开(公告)日：2009-04-16
申请号：US12170078
申请日：2008-07-09
IPC分类号： A61K31/7105 , A61K31/713 , C07H21/02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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