公开(公告)号：US08394344B2

公开(公告)日：2013-03-12

申请号：US12976925

申请日：2010-12-22

申请人： Alexander Schutt ,  Martin Trump

发明人： Alexander Schutt ,  Martin Trump

IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC分类号： G01N35/026 ,  B01L9/06 ,  B01L2200/025 ,  B01L2200/143 ,  G01N2035/0429 ,  G01N2035/0493 ,  Y10T436/11

摘要： An indicator for enabling an analytical instrument to positively detect the presence of a vial in respective vial-receiving rack position regardless of whether the vial is oriented in a manner necessary for a code reader to read a code printed on the vial. Translation of a leaf spring upon insertion of a vial into a rack position causes a flag to obscure a code provided adjacent the rack position. An instrument into which the rack is installed interprets the failure of the code reader to detect this code as positive indication that a vial is disposed within the respective rack position.

摘要翻译： 用于使得分析仪器能够在相应的小瓶容纳架位置中积极地检测小瓶的存在的指示器，而不管小瓶是否以编码阅读器读取在小瓶上打印的代码所必需的方式定向。 当将小瓶插入机架位置时，板簧的翻译会导致标志遮盖在机架位置附近提供的代码。 安装机架的仪器解释了代码阅读器的故障，将该代码检测为一个小瓶被置于相应机架位置的正面指示。

公开(公告)号：US20090176308A1

公开(公告)日：2009-07-09

申请号：US12270621

申请日：2008-11-13

申请人： Ralf Griebel ,  Hans Joos ,  Peter Bendzko

发明人： Ralf Griebel ,  Hans Joos ,  Peter Bendzko

IPC分类号： G01N1/34 ,  B01L3/02 ,  B01L11/00

CPC分类号： B01F11/0082 ,  C12N15/1013 ,  G01N35/0098

摘要： The invention comprises an apparatus 10 and a method 100 for automatically lysing, extracting and purifying biomolecules 28. As the central technology for purifying the biomolecules magnetizable particles 35 and an adapted magnet device 40 are used for binding and transferring the particles 35. The apparatus 10 comprises a highly efficient incubation unit 60 with options for upscaling the maximum sample amount. Furthermore the apparatus 10 in particular comprises a group of magnetizable pins 40 as transport magnets and furthermore counter magnets 50 which are arranged on the cavities 20, in which solutions 30 with the biomolecules 28 to be lysed and magnetizable particles 35 are disposed. The use of counter magnets 50 improves the quality of the eluate. Furthermore the invention comprises a fully automatic system 800 and a method 100 for controlling the process steps and the selection of the reagents and the aids (e.g. magnetizable particles 35) on the basis of automatically detected information, such as gathered e.g. from the loaded samples and/or from the used reagents. The automated overall system 800 in particular fulfils the requirements of medical diagnostics.

摘要翻译： 本发明包括用于自动裂解，提取和纯化生物分子28的装置10和方法100.作为用于纯化生物分子可磁化颗粒35的中心技术和适用的磁性装置40用于结合和转移颗粒35.装置10 包括具有用于放大最大样品量的选项的高效孵育单元60。 此外，装置10特别地包括一组作为输送磁体的可磁化销钉40以及布置在空腔20上的反磁体50，其中设置有待裂解的生物分子28和可磁化颗粒35的溶液30。 反磁体50的使用提高了洗脱液的质量。 此外，本发明包括全自动系统800和方法100，用于基于自动检测的信息来控制处理步骤和选择试剂和助剂（例如可磁化颗粒35） 从装载的样品和/或来自使用的试剂。 自动整体系统800特别满足了医疗诊断的要求。

公开(公告)号：US07916299B2

公开(公告)日：2011-03-29

申请号：US12017256

申请日：2008-01-21

申请人： Martin Trump ,  Oliver Burk

发明人： Martin Trump ,  Oliver Burk

IPC分类号： G01N21/00

CPC分类号： G01F1/74 ,  G01F1/704

摘要： The device and the method are used for optical detection of at least one phase transition between at least two media, which are taken into a line and/or dispensed from the line by an intake and/or dispensing device. A light-emitting transmitter emits light across and onto the line at a measurement point provided for this purpose. A receiver receives the emitted light, which is influenced by media in the line, to form reception signals. At least one waveguide, which is arranged up to the measurement point on the probe, is provided between the transmitter and/or the receiver and the measurement point (M). Due to the fact that the waveguide is arranged in parallel to the line at least in the area near the probe and at least one deflection lens is provided in the area of the measurement point to deflect the light emitted and/or the light to be detected, a phase boundary or state can be detected, and the dead volume is reduced.

摘要翻译： 所述装置和方法用于光学检测至少两个介质之间的至少一个相变，所述至少两个介质被进入和/或分配装置从管线中取出和/或从管线分配。 发光发射器在为此目的提供的测量点上发射光并在线上发射光线。 接收器接收受线中介质影响的发射光，形成接收信号。 在发射器和/或接收器和测量点（M）之间设置至少一个布置在探头上的测量点的波导。 由于波导至少在探针附近的区域平行布置，并且至少一个偏转透镜设置在测量点的区域中，以偏转被发射的光和/或待检测的光 ，可以检测相位边界或状态，减少死体积。

公开(公告)号：US20100288705A1

公开(公告)日：2010-11-18

申请号：US12778219

申请日：2010-05-12

申请人： Ralf Griebel

发明人： Ralf Griebel

IPC分类号： B03C1/02

CPC分类号： B03C1/286 ,  B03C1/0332 ,  B03C2201/18 ,  G01N35/0098 ,  G01N35/10

摘要： A rod assembly for the extraction of magnetizable particles from solutions is described. The rod assembly includes at least one guide element. A rod element is insertable into the at least one guide element and moveable in a direction substantially parallel to the at least one guide element. A magnet element is moveable to a distal magnet element position; wherein the distal magnet element position is located on a distal end section of the at least one guide element; wherein the at least one guide element includes an opening at a distal end. A method for the extraction of magnetizable particles from solutions is also described, as well as a magnet element for the extraction of magnetizable particles from solutions.

摘要翻译： 描述了用于从溶液中提取可磁化颗粒的棒组件。 杆组件包括至少一个引导元件。 杆元件可插入到至少一个引导元件中并且可在基本上平行于至少一个引导元件的方向上移动。 磁铁元件可移动到远端磁铁元件位置; 其中所述远端磁体元件位置位于所述至少一个引导元件的远端部分上; 其中所述至少一个引导元件包括在远端的开口。 还描述了从溶液中提取可磁化颗粒的方法，以及用于从溶液中提取可磁化颗粒的磁体元件。

公开(公告)号：US20080192255A1

公开(公告)日：2008-08-14

申请号：US12017256

申请日：2008-01-21

申请人： Oliver Burk ,  Martin Trump

发明人： Oliver Burk ,  Martin Trump

IPC分类号： G01N21/00

CPC分类号： G01F1/74 ,  G01F1/704

摘要： The device and the method are used for optical detection of at least one phase transition between at least two media, which are taken into a line and/or dispensed from the line by an intake and/or dispensing device. A light-emitting transmitter emits light across and onto the line at a measurement point provided for this purpose. A receiver receives the emitted light, which is influenced by media in the line, to form reception signals. At least one waveguide, which is arranged up to the measurement point on the probe, is provided between the transmitter and/or the receiver and the measurement point (M). Due to the fact that the waveguide is arranged in parallel to the line at least in the area near the probe and at least one deflection lens is provided in the area of the measurement point to deflect the light emitted and/or the light to be detected, a phase boundary or state can be detected, and the dead volume is reduced.

摘要翻译： 所述装置和方法用于光学检测至少两个介质之间的至少一个相变，所述至少两个介质被进入和/或分配装置从管线中取出和/或从管线分配。 发光发射器在为此目的提供的测量点上发射光并在线上发射光线。 接收器接收受线中介质影响的发射光，形成接收信号。 在发射器和/或接收器和测量点（M）之间设置至少一个布置在探头上的测量点的波导。 由于波导至少在探针附近的区域平行布置，并且至少一个偏转透镜设置在测量点的区域中，以偏转被发射的光和/或待检测的光 ，可以检测相位边界或状态，减少死体积。

公开(公告)号：US20080019878A1

公开(公告)日：2008-01-24

申请号：US11781774

申请日：2007-07-23

申请人： MARTIN TRUMP

发明人： MARTIN TRUMP

IPC分类号： B01L3/02

CPC分类号： G01N35/1011 ,  G01N35/109

摘要： “A positioning device is provided for positioning pipettes in medical-technical applications including at least one pipetting apparatus with at least one pipette as well as several drive units for positioning a pipette tip and for moving it over a working area and transversely to a working area, a sliding carriage that is moveable transversely to the working area supports the pipette, at least one pump drive with at least one pump and at least one pump chamber is provided for aspirating or dispensing a medium, such that by providing the at least one pump drive with pump and at least one pump chamber integrated in the sliding carriage that is moveable transversely to the working area, the design of the positioning device becomes compact and precise pipetting is achieved.

摘要翻译： “提供了一种用于将移液管定位在医疗技术应用中的定位装置，其包括至少一个具有至少一个移液管的移液装置以及用于定位移液管末端并用于将其移动到工作区域并横向于工作区域的多个驱动单元 可横向于工作区域移动的滑动支架支撑移液管，提供具有至少一个泵和至少一个泵室的至少一个泵驱动器，用于吸入或分配介质，使得通过提供至少一个泵 驱动泵和集成在滑动架中的至少一个泵室，其能够横向于工作区域移动，定位装置的设计变得紧凑而精确的移液。

公开(公告)号：US07976794B2

公开(公告)日：2011-07-12

申请号：US11781774

申请日：2007-07-23

申请人： Martin Trump

发明人： Martin Trump

IPC分类号： B01L3/02

CPC分类号： G01N35/1011 ,  G01N35/109

摘要： A positioning device is provided for positioning pipettes in medical-technical applications including at least one pipetting apparatus with at least one pipette as well as several drive units for positioning a pipette tip and for moving it over a working area and transversely to a working area, a sliding carriage that is moveable transversely to the working area supports the pipette, at least one pump drive with at least one pump and at least one pump chamber is provided for aspirating or dispensing a medium, such that by providing the at least one pump drive with pump and at least one pump chamber integrated in the sliding carriage that is moveable transversely to the working area, the design of the positioning device becomes compact and precise pipetting is achieved.

摘要翻译： 提供了一种定位装置，用于将移液管定位在医疗技术应用中，包括至少一个具有至少一个移液管的移液装置以及用于定位移液管末端并用于将其移动到工作区域并横向于工作区域的多个驱动单元， 可横向于工作区域移动的滑动支架支撑移液管，至少一个具有至少一个泵和至少一个泵室的泵驱动器被提供用于吸入或分配介质，使得通过提供至少一个泵驱动器 具有泵和至少一个集成在滑动架中的泵室，其可横向于工作区域移动，定位装置的设计变得紧凑且精确的移液。

公开(公告)号：US07858031B2

公开(公告)日：2010-12-28

申请号：US11597220

申请日：2005-05-24

申请人： Alexander Schutt ,  Martin Trump

发明人： Alexander Schutt ,  Martin Trump

IPC分类号： B01L3/02 ,  B01L99/00

CPC分类号： G01N35/026 ,  B01L9/06 ,  B01L2200/025 ,  B01L2200/143 ,  G01N2035/0429 ,  G01N2035/0493 ,  Y10T436/11

摘要： An indicator for enabling an analytical instrument to positively detect the presence of a vial in respective vial-receiving rack position regardless of whether the vial is oriented in a manner necessary for a code reader to read a code printed on the vial. Translation of a leaf spring upon insertion of a vial into a rack position causes a flag to obscure a code provided adjacent the rack position. An instrument into which the rack is installed interprets the failure of the code reader to detect this code as positive indication that a vial is disposed within the respective rack position.

摘要翻译： 用于使得分析仪器能够在相应的小瓶容纳架位置中积极地检测小瓶的存在的指示器，而不管小瓶是否以编码阅读器读取在小瓶上打印的代码所必需的方式定向。 当将小瓶插入机架位置时，板簧的翻译会导致标志遮盖在机架位置附近提供的代码。 安装机架的仪器解释了代码阅读器的故障，将该代码检测为一个小瓶被置于相应机架位置的正面指示。

公开(公告)号：US07694591B2

公开(公告)日：2010-04-13

申请号：US11642116

申请日：2006-12-20

申请人： Thomas Leibfried

发明人： Thomas Leibfried

IPC分类号： B01L3/02 ,  G01F19/00

CPC分类号： G01F11/029 ,  B01L3/0217 ,  B01L2200/146 ,  B01L2200/148 ,  G01N35/1009 ,  G01N2035/1018

摘要： During a method of evaluating a dosing operation, carried out by means of a dosing pump, for dosing a liquid medium in a vessel, filled at least partially with a gas, a pressure profile of the gas, present in the vessel, is detected at least periodically during the dosing operation. This pressure profile is compared with a desired value profile, prescribed for a control unit of the dosing pump, of the pump rate or pump output defining the dosing operation, and an evaluation result is issued in dependence on the comparison. In such case, the dosing operation is evaluated to be faulty or in need of correction when it is determined that the detected pressure profile over time with the prescribed pump rate or prescribed pump output lies outside a desired value range. A plurality of error conditions for the evaluation of the dosing operation are used, which consider the pressure development in a time window after a prescribed change in the defining pump rate or pump output.

摘要翻译： 在评估通过计量泵进行的计量操作的方法中，用于对容器中的至少部分填充有气体的容器中的液体介质进行计量，存在于容器中的气体的压力分布在 在给药操作期间最不周期。 将该压力分布与定量给料泵的控制单元规定的期望值曲线进行比较，定义给料操作的泵送速率或泵输出，并且根据比较发布评估结果。 在这种情况下，当确定随着规定的泵送速率或规定的泵输出的检测到的压力分布在所期望的值范围之外时，将计量操作评估为有故障或需要校正。 使用用于评估给料操作的多个误差条件，其在规定的泵速或泵输出的规定变化之后考虑在时间窗中的压力发展。